Debruhl-Marshall House

Columbia Historic District II is a national historic district located at Columbia, South Carolina. The district encompasses 113 contributing buildings and 1 contributing site in a former residential section of Columbia. They were built between the early-19th century and the 1930s (majority between 1900 and 1918) and are now mostly used for commercial purposes. The buildings are in the Greek Revival, Gothic Revival, Classical Revival, and the “Columbia Cottage” styles. Notable buildings include the Robert Mills House, Debruhl-Marshall House, Hampton-Preston House, Episcopal Church of the Good Shepherd, Crawford-Clarkson House, Maxcy Gregg House, Hale-Elmore-Seibels House, St. Paul's Lutheran Church, and Ebenezer Lutheran Church.It was added to the National Register of Historic Places in 1971. It was enlarged in 1982, and underwent a boundary adjustment in 2018.

Mann-Simons Cottage is a historic home located at Columbia, South Carolina. It was built around 1850, and is a 1+1⁄2-story, cottage style frame house on a raised basement. The front façade features a porch supported by four Tuscan order columns. It was the antebellum home of a substantial free black Columbia family.The house now serves as a museum, with tours offered six days a week. It was added to the National Register of Historic Places in 1973.

Ladson Presbyterian Church is a historic African American Presbyterian church located at 1720 Sumter Street in Columbia, South Carolina. The religious building was initially a chapel founded in 1838 and, rebuilt in 1896, and is a one-story-over-raised-basement, rectangular red brick building in the Renaissance Revival style. It has a front gable roof and features two brick entrance towers. The congregation was founded in 1838, as an offshoot congregation of the First Presbyterian Church.It was added to the National Register of Historic Places in 1998.

Ebenezer Lutheran Chapel is a historic Lutheran chapel located in Columbia, South Carolina. It was built in 1830, and rebuilt in 1870, while the restoration took place in 1993 and is a brick church that was extensively renovated in 1900. The front façade features two square towers and finely detailed art glass windows. Adjacent to the church is a Lutheran cemetery which dates to the early 1800s.It was added to the National Register of Historic Places in 1979.

The Greyhound Bus Depot is a former Greyhound Lines intercity bus station in Columbia, South Carolina. It is at 1200 Blanding Street in downtown Columbia. The depot was named to the National Register of Historic Places on December 28, 1989. After the bus terminal was closed, the building became a bank. Currently, it is a physician's office.

The Columbia Commercial Historic District encompasses a historically significant portion of the central business district of Columbia, South Carolina. It includes portions of three blocks of Main Street between Laurel and Hampton Streets, as well as individual buildings on adjacent streets. It includes the full length of Main Streets east side on these blocks, but only the central block (between Blanding and Taylor Streets) on the west side, extending slightly south of Taylor. This area best illustrates the city's commercial and economic growth for a century, from the end of the American Civil War to about 1963, with a broad diversity of architectural styles found in a small area.The district was added to the National Register of Historic Places in 2014, and has twice been enlarged. Nine of the district's 36 buildings are also individually listed.

Columbia Historic District I is a national historic district located in the Arsenal Hill neighborhood at Columbia, South Carolina. The district encompasses nine contributing buildings and includes a complex of fine mansions and attractive homes built before the American Civil War. The buildings are in the Greek Revival, Italianate, Classical Revival, and the “Columbia Cottage” styles. They include the Governor's Mansion, Caldwell-Hampton-Boylston House, Lace House, and Palmetto Iron Works and Armory.It was added to the National Register of Historic Places in 1971.

The South Carolina Science Academy (SCSA) was a tuition-free public charter school in Columbia, South Carolina, open to all students that reside in South Carolina. SCSA was a publicly funded school that focuses on science, technology, engineering, and mathematics (STEM). The school currently had enrollment of 136 students in grades 6–12 at the time of closing. The target student population was 450 students. The inaugural year for the South Carolina Science Academy was originally set to be 2012, but the sudden death of the school's founder, Mr. Nathan Yon, pushed that date back to 2014.The SC Science Academy had received a ten-year charter, had been approved by the South Carolina Department of Education, and was authorized by the South Carolina Public Charter School District in 2011. In accordance with the charter school model, an annually elected board of directors composed of local business leaders, educators, and parents governed the school.Enrollment in the 2016 school year was 140 students.The school was AdvancED accredited, and it rated "Good" in opportunities in foreign language. In 2016, the school had 1.3 professional development days per teacher, and 37.5% of its teachers were on continuing contracts.On May 10, 2018, the South Carolina Public Charter School District voted to revoke SC Science Academy's charter, closing the school at the end of the year.

The Hale–Elmore–Seibels House or Seibels House is a historic building located in Columbia, South Carolina. Records of the exact year of its construction were destroyed in 1865 during the burning of the city by Union soldiers serving under General William Tecumseh Sherman. The best guess for the date of construction stems from a purported "1796" carved into a beam in the basement. Much of the early history of the house is uncertain, but it is thought to be the oldest building in Columbia.Located at 1601 Richland Street, the house is the headquarters of Historic Columbia, a non-profit organization dedicated to preserving Columbia and Richland County's historic and cultural heritage, and its grounds are open to the public for visitation. Its extensive restored garden serves as the backdrop for wedding receptions and other events.

Bethel A.M.E. Church is a historic African Methodist Episcopal Church at 1528 Sumter Street in Columbia, South Carolina.It was built in 1921 and added to the National Register in 1982.

Prisma Health Baptist Hospital (Formerly Baptist Medical Center and Palmetto Health Baptist Columbia) is a 489-bed acute-care facility located at the intersection of Taylor and Marion Streets in Downtown Columbia, South Carolina. The hospital was established in 1914 as South Carolina Baptist Hospital by the South Carolina Baptist Convention after the widow of Dr. Augustus B. Knowlton, a prominent Columbia physician, asked the church to purchase the hospital, at that time a 70-bed facility on Marion St., that she and her husband started. Over the years, the hospital expanded and grew as additional services were offered. Baptist Columbia became part of the Baptist Healthcare System when a second Baptist hospital was built in Easley, South Carolina in 1958. In 1998, the two-hospital Baptist Healthcare System merged with Richland Memorial Hospital to form Palmetto Health, the largest healthcare system in South Carolina at the time. In 2017, Palmetto Health merged with the Greenville Hospital System to form Prisma Health and continues as the largest not-for profit hospital operator in South Carolina.

The Bouchier Building is a historic commercial building located in Columbia, South Carolina. It was built in 1913–14, and is a three-story, terra cotta faced building with large areas of glass on the upper floors.It was added to the National Register of Historic Places as the Building at 1722–1724 Main Street in 1979.