South Carolina Science Academy

The Modjeska Monteith Simkins House is a historic place of the civil rights movement. The house, which was owned by Modjeska Monteith Simkins, is located at 2025 Marion Street in Columbia, South Carolina. On March 25, 1994, it was named to the National Register of Historic Places.

Ebenezer Lutheran Chapel is a historic Lutheran chapel located in Columbia, South Carolina. It was built in 1830, and rebuilt in 1870, while the restoration took place in 1993 and is a brick church that was extensively renovated in 1900. The front façade features two square towers and finely detailed art glass windows. Adjacent to the church is a Lutheran cemetery which dates to the early 1800s.It was added to the National Register of Historic Places in 1979.

Mann-Simons Cottage is a historic home located at Columbia, South Carolina. It was built around 1850, and is a 1+1⁄2-story, cottage style frame house on a raised basement. The front façade features a porch supported by four Tuscan order columns. It was the antebellum home of a substantial free black Columbia family.The house now serves as a museum, with tours offered six days a week. It was added to the National Register of Historic Places in 1973.

The South Carolina State Hospital was a publicly funded state-run psychiatric hospital in Columbia, South Carolina. Founded in 1821 as the South Carolina Lunatic Asylum, it was one of the first public mental hospitals established in the United States. The Mills Building, its first building, was designed by early American architect Robert Mills, and is a National Historic Landmark. The hospital had more than 1,000 patients in 1900, but with the transition of mental health facilities to community settings, it closed in the late 1990s. While buildings on the campus were temporarily used for inpatient services into the early 2000s, they were not part of the State Hospital, but other inpatient facilities of the agency (e.g., Morris Village Alcohol and Drug Treatment Center and G. Werber Bryan Psychiatric Hospital). Several buildings on its campus housed offices and storage facilities of the state's Department of Mental Health until approximately 2014. In October of 2014, the Department sold the first parcels of the property into private ownership and received the first sale proceeds ($1.5 Million). The William S. Hall Psychiatric Institute (an inpatient psychiatric facility for children and adolescents) remained on the campus until 2015, when it moved to a new facility on Department's Northeast Columbia Campus. As of January 2021, 100% of the South Carolina State Hospital (also known as "Bull Street") property had been transferred to private ownership. Proceeds from the sale of the Bull Street property must be used to benefit patients of the Agency. As of August 2020, the SC Mental Health Commission had authorized the expenditure of $10 million of the proceeds, $6.5 million, for the development of additional community housing for patients.

Columbia Historic District I is a national historic district located in the Arsenal Hill neighborhood at Columbia, South Carolina. The district encompasses nine contributing buildings and includes a complex of fine mansions and attractive homes built before the American Civil War. The buildings are in the Greek Revival, Italianate, Classical Revival, and the “Columbia Cottage” styles. They include the Governor's Mansion, Caldwell-Hampton-Boylston House, Lace House, and Palmetto Iron Works and Armory.It was added to the National Register of Historic Places in 1971.

Columbia Historic District II is a national historic district located at Columbia, South Carolina. The district encompasses 113 contributing buildings and 1 contributing site in a former residential section of Columbia. They were built between the early-19th century and the 1930s (majority between 1900 and 1918) and are now mostly used for commercial purposes. The buildings are in the Greek Revival, Gothic Revival, Classical Revival, and the “Columbia Cottage” styles. Notable buildings include the Robert Mills House, Debruhl-Marshall House, Hampton-Preston House, Episcopal Church of the Good Shepherd, Crawford-Clarkson House, Maxcy Gregg House, Hale-Elmore-Seibels House, St. Paul's Lutheran Church, and Ebenezer Lutheran Church.It was added to the National Register of Historic Places in 1971. It was enlarged in 1982, and underwent a boundary adjustment in 2018.

Debruhl-Marshall House is a historic home located in Columbia, South Carolina. It was built in 1820, and is a two-story, five bay, brick Greek Revival style dwelling. It has a gabled slate roof and full basement. The front facade features a three bay portico supported by four massive Doric order columns.It was added to the National Register of Historic Places in 1972. It is located in the Columbia Historic District II.

Jefferson Square, an office complex in downtown Columbia, South Carolina, is the headquarters of the state's Department of Health and Human Services which oversees the Medicaid program for South Carolinians. Located at 1801 Main St. in the city's historic Arsenal Hill neighborhood, the complex includes a 15-story, 150,000 sq ft (14,000 m2) office tower and a two-story courtyard plaza. Also on the Jefferson Square block (bordered by Laurel, Assembly, Richland, and Main) are the offices of Wilson-Kibler real estate, two parking garages, a parking lot, and the Arsenal Hill Associate Reformed Presbyterian Church.

Ladson Presbyterian Church is a historic African American Presbyterian church located at 1720 Sumter Street in Columbia, South Carolina. The religious building was initially a chapel founded in 1838 and, rebuilt in 1896, and is a one-story-over-raised-basement, rectangular red brick building in the Renaissance Revival style. It has a front gable roof and features two brick entrance towers. The congregation was founded in 1838, as an offshoot congregation of the First Presbyterian Church.It was added to the National Register of Historic Places in 1998.

The Hale–Elmore–Seibels House or Seibels House is a historic building located in Columbia, South Carolina. Records of the exact year of its construction were destroyed in 1865 during the burning of the city by Union soldiers serving under General William Tecumseh Sherman. The best guess for the date of construction stems from a purported "1796" carved into a beam in the basement. Much of the early history of the house is uncertain, but it is thought to be the oldest building in Columbia.Located at 1601 Richland Street, the house is the headquarters of Historic Columbia, a non-profit organization dedicated to preserving Columbia and Richland County's historic and cultural heritage, and its grounds are open to the public for visitation. Its extensive restored garden serves as the backdrop for wedding receptions and other events.

The Columbia City Hall, in Columbia, South Carolina, also known as Old United States Court House and Post Office, was built in 1870. It was listed on the National Register of Historic Places in 1973. It includes Renaissance architecture. It served historically as a courthouse and as a post office.It was designed by Alfred B. Mullett.

The Bouchier Building is a historic commercial building located in Columbia, South Carolina. It was built in 1913–14, and is a three-story, terra cotta faced building with large areas of glass on the upper floors.It was added to the National Register of Historic Places as the Building at 1722–1724 Main Street in 1979.