House of the Good Samaritan

The Medical Area Total Energy Plant, in Boston, Massachusetts, is a gas-fired co-generation power plant providing steam, chilled water, and electricity to the Longwood Medical Area. Proposed in 1974 and completed in 1986, the facility encountered fierce community opposition and cost $350 million‍—‌$310 million more than the originally projected $40 million.

The Boston Psychopathic Hospital, established at 74 Fenwood Road in 1912, was one of the first mental health hospitals in Massachusetts, United States. The building was listed on the National Register of Historic Places in 1994. The name was changed to Massachusetts Mental Health Center in the late 1960s. The building at 74 Fenwood Road was closed in 2010 and demolished in 2011. The Massachusetts Mental Health Center continues to operate at 75 Fenwood Road.

Beth Israel Deaconess Medical Center (BIDMC) in Boston, Massachusetts is a teaching hospital of Harvard Medical School. It was formed out of the 1996 merger of Beth Israel Hospital (founded in 1916) and New England Deaconess Hospital (founded in 1896). Among independent teaching hospitals, Beth Israel Deaconess Medical Center consistently ranks in the top three recipients of biomedical research funding from the National Institutes of Health. Research funding totals nearly $200 million annually. BIDMC researchers run more than 850 active sponsored projects and 200 clinical trials. The Harvard-Thorndike General Clinical Research Center, the oldest clinical research laboratory in the United States, has been located on this site since 1973.

Dana–Farber Cancer Institute is a comprehensive cancer treatment and research institution in Boston, Massachusetts. Dana–Farber is the founding member of Dana–Farber/Harvard Cancer Center, Harvard's Comprehensive Cancer Center designated by the National Cancer Institute, and one of the 15 clinical affiliates and research institutes of Harvard Medical School. As of 2023, Dana–Farber is ranked the #4 cancer hospital in the world. Two Nobel laureates in Physiology or Medicine are among its past and present faculty. Dana–Farber's research discoveries include the development of the highly successful Gleevec to treat chronic myeloid leukemia.

Brigham and Women's Hospital (BWH) is the second largest teaching hospital of Harvard Medical School and the largest hospital in the Longwood Medical Area in Boston, Massachusetts. Along with Massachusetts General Hospital, it is one of the two founding members of Mass General Brigham, the largest healthcare provider in Massachusetts. Robert Higgins, MD, MSHA serves as the hospital's current president.Brigham and Women's Hospital conducts the second largest (behind MGH) hospital-based research program in the world, with an annual research budget of more than $630 million. Pioneering achievements at BWH have included the world's first successful heart valve operation and the world's first solid organ transplant. In the 2022 U.S. News & World Report hospital rankings, BWH was ranked fourteenth nationally.

The Massachusetts Mental Health Center is a historic psychiatric hospital complex at 75 Fenwood Road in the Longwood medical area of Boston, Massachusetts. The center was founded in 1912 as the Boston Psychopathic Hospital. Its original main building and power plant were built that year, with additions in later decades including a therapeutic wing (1954) and research building (1957). The entire property was surrounded by an iron picket fence. It was listed on the National Register of Historic Places in 1994, representing one of the nation's oldest psychiatric hospitals. In 2009 the center's historic campus at 74 Fenwood Road was acquired by Partners HealthCare and demolished the following year. The center continues to operate in modern facilities at 75 Fenwood Road.

The Francis Street–Fenwood Road Historic District encompasses a small but cohesive early 20th-century residential area and streetcar suburb in the Longwood area of Boston, Massachusetts. Bounded by Huntington Avenue, Francis Street, Vining Avenue, Fenwood Road, and St. Albans Road, it includes a collection of two and three-family houses, as well as two apartment houses, a school, and one commercial building, all of which predate the large medical complexes that dominate the Longwood area. The district was listed on the National Register of Historic Places in 2016.

Boston Children's Hospital formerly known as Children's Hospital Boston until 2013 is a nationally ranked, freestanding acute care children's hospital located in Boston, Massachusetts, adjacent both to its teaching affiliate, Harvard Medical School, and to Dana–Farber Cancer Institute. Dana–Farber and Children's jointly operate the Dana–Farber/Boston Children's Cancer and Blood Disorders Center to deliver comprehensive care for all types of childhood cancers. The hospital is home to the largest hospital-based pediatric research program in the world. The hospital features 485 pediatric beds and provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21 throughout Massachusetts, the United States, and the world. The hospital also sometimes treats adults that require pediatric care. The hospital uses the Brigham and Women's Hospital's rooftop helipad and is an ACS verified level I pediatric trauma center, one of three in Boston. The hospital features a regional pediatric intensive-care unit and an American Academy of Pediatrics verified level IV neonatal intensive care unit. Boston Children's Hospital has been ranked as best pediatric medical center by U.S. News & World Report more times than any other hospital and is currently ranked as the best children's hospital in the United States. Its research enterprise is the world's largest and most highly funded pediatric hospital. In FY2022, Children's received more funding from the National Institutes of Health than any other children's hospital in the nation.

Joslin Diabetes Center is the world's largest diabetes research center, diabetes clinic, and provider of diabetes education. It is located in the Longwood Medical and Academic Area in Boston, Massachusetts, United States. Among the Harvard Medical School affiliated institutions, Joslin is unique in its sole focus on diabetes. Joslin has the world's largest team of board-certified physicians treating diabetes and its complications, as well as the largest staff of Certified Diabetes Educators anywhere in the world. Joslin also supports the world's largest diabetes research team with more than 40 faculty investigators and more than 300 researchers.Roberta Herman, M.D., is currently President and CEO of Joslin Diabetes Center.

Mission Hill is a 3⁄4 square mile (2 square km), primarily residential neighborhood of Boston, bordered by Roxbury, Jamaica Plain and Fenway-Kenmore and the town of Brookline. It is home to several hospitals and universities, including Brigham and Women's Hospital and New England Baptist Hospital. Mission Hill is known for its brick row houses and triple decker homes of the late 19th century. The population was estimated at 15,883 in 2011.

The Longwood Medical and Academic Area (also known as Longwood Medical Area, LMA, or simply Longwood) is a medical campus in Boston, Massachusetts. Flanking Longwood Avenue, LMA is adjacent to the Fenway–Kenmore, Audubon Circle, and Mission Hill neighborhoods, as well as the town of Brookline.It is most strongly associated with Harvard Medical School, the Harvard T.H. Chan School of Public Health, the Harvard School of Dental Medicine, and other medical facilities such as Harvard's teaching hospitals, but prominent non-Harvard institutions are located there as well. Long known as a global center of research, institutions in the Longwood Medical Area secured over $1.2 billion in NIH funds alone, in FY 2018 which exceeds funding received by 44 states.

The Massachusetts School of Art is an historic academic building at 364 Brookline Avenue in the Longwood Medical Area of Boston, Massachusetts. The four-story Gothic/Art Deco building was designed by the architectural firm of Henry & Richmond, and was built in 1929-30 for the Massachusetts College of Art. The school occupied the building until 1983, when it moved to its present campus on Huntington Avenue. The building is now part of the Beth Israel Deaconess Medical Center. The building was listed on the National Register of Historic Places in 1989 and is currently under study for landmark status by the Boston Landmarks Commission.