Francis Street–Fenwood Road Historic District

Fenwood Road station is a light rail stop on the MBTA Green Line E branch, located on Huntington Avenue at Fenwood Road in the Mission Hill neighborhood of Boston, Massachusetts. Fenwood Road is the third-least-used stop on the Green Line (after Back of the Hill and South Street), with 221 daily boardings by a 2011 count.The station is located on a street running segment of the E branch; trains run in mixed traffic rather than a dedicated median. The station has no platforms; riders wait on the sidewalks (shared with bus stops for the route 39 and 66 buses) and cross the street to reach trains. Because of this, the station is not accessible. In 2021, the MBTA indicated plans to modify the Heath Street–Brigham Circle section of the E branch with accessible platforms to replace the existing non-accessible stopping locations.

Brigham and Women's Hospital (BWH) is the second largest teaching hospital of Harvard Medical School and the largest hospital in the Longwood Medical Area in Boston, Massachusetts. Along with Massachusetts General Hospital, it is one of the two founding members of Mass General Brigham, the largest healthcare provider in Massachusetts. Robert Higgins, MD, MSHA serves as the hospital's current president.Brigham and Women's Hospital conducts the second largest (behind MGH) hospital-based research program in the world, with an annual research budget of more than $630 million. Pioneering achievements at BWH have included the world's first successful heart valve operation and the world's first solid organ transplant. In the 2022 U.S. News & World Report hospital rankings, BWH was ranked fourteenth nationally.

Paris-Saclay Medical School, also Faculté de médecine Paris-Saclay in French, is the graduate medical school of Paris-Saclay University and is located in the Bicêtre Medical Area of Le Kremlin-Bicêtre, Val-de-Marne, France and founded in 1968. It is the medical school of the first university in France according to its dean.

Brigham Circle is located at the intersection of Tremont Street and Huntington Avenue in the Mission Hill neighborhood of Boston, Massachusetts. The commercial center of Mission Hill, it forms the southern tip of the Longwood Medical Area.The area is named for the Peter Bent Brigham Hospital (now a wing of the larger Brigham and Women's Hospital), which stands at one side of the circle and is approached through Stoneman Plaza. The intersection was never a true traffic circle like other circles in Boston. Huntington Avenue has had through lanes since at least the early 20th century; a small rotary was present at the junction of Francis Street on the northwest side. Near MBTA stops is a street-level park with metal benches that sites farmers' markets, and entrances to Kevin W. Fitzgerald Park (formerly Puddingstone Park) and other parks are nearby.

Mission Hill is a 3⁄4 square mile (2 square km), primarily residential neighborhood of Boston, bordered by Roxbury, Jamaica Plain and Fenway-Kenmore and the town of Brookline. It is home to several hospitals and universities, including Brigham and Women's Hospital and New England Baptist Hospital. Mission Hill is known for its brick row houses and triple decker homes of the late 19th century. The population was estimated at 15,883 in 2011.

The Boston Psychopathic Hospital, established at 74 Fenwood Road in 1912, was one of the first mental health hospitals in Massachusetts, United States. The building was listed on the National Register of Historic Places in 1994. The name was changed to Massachusetts Mental Health Center in the late 1960s. The building at 74 Fenwood Road was closed in 2010 and demolished in 2011. The Massachusetts Mental Health Center continues to operate at 75 Fenwood Road.

The House of the Good Samaritan (sometimes called the Boston Good Samaritan Hospital) was a charitable, Boston hospital founded by Anne Smith Robbins in 1860. It accepted its first patients in 1861 and was established to care for destitute, chronically ill women and children. The hospital became affiliated in 1946 with Boston Children's Hospital. It was legally incorporated into Boston Children's Hospital in March 1967.

The Boston Medical Library (est. 1875) of Boston, Massachusetts, was originally organized to alleviate the problem that had emerged due to the scattered distribution of medical texts throughout the city. It has evolved into the "largest academic medical library in the world".

Boston Children's Hospital formerly known as Children's Hospital Boston until 2013 is a nationally ranked, freestanding acute care children's hospital located in Boston, Massachusetts, adjacent both to its teaching affiliate, Harvard Medical School, and to Dana–Farber Cancer Institute. Dana–Farber and Children's jointly operate the Dana–Farber/Boston Children's Cancer and Blood Disorders Center to deliver comprehensive care for all types of childhood cancers. The hospital is home to the largest hospital-based pediatric research program in the world. The hospital features 485 pediatric beds and provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21 throughout Massachusetts, the United States, and the world. The hospital also sometimes treats adults that require pediatric care. The hospital uses the Brigham and Women's Hospital's rooftop helipad and is an ACS verified level I pediatric trauma center, one of three in Boston. The hospital features a regional pediatric intensive-care unit and an American Academy of Pediatrics verified level IV neonatal intensive care unit. Boston Children's Hospital has been ranked as best pediatric medical center by U.S. News & World Report more times than any other hospital and is currently ranked as the best children's hospital in the United States. Its research enterprise is the world's largest and most highly funded pediatric hospital. In FY2022, Children's received more funding from the National Institutes of Health than any other children's hospital in the nation.

Brigham Circle station is a station on the light rail MBTA Green Line "E" branch, located just east of Brigham Circle in the Mission Hill neighborhood of Boston, Massachusetts. With raised platforms installed in a 2001-03 renovation, the station is accessible when served by low-floor streetcars. The two side platforms are staggered, with the outbound platform further west. Crosswalks across Huntington Avenue to the station are present at Brigham Circle (to the outbound platform), between the two platforms, and at Wigglesworth Street (to the inbound platform). East of Brigham Circle, the E branch runs in a dedicated reservation in the median of Huntington Avenue; west of the circle is street running in mixed traffic to the terminus at Heath Street. Because of this, service is often terminated at Brigham Circle due to traffic conditions to preserve service frequency on the remainder of the line. At these times, the parallel 39 bus provides all service west of Brigham Circle. A facing point crossover is located just east of the station, allowing terminating trains to cross over to the inbound platform.

The Medical Area Total Energy Plant, in Boston, Massachusetts, is a gas-fired co-generation power plant providing steam, chilled water, and electricity to the Longwood Medical Area. Proposed in 1974 and completed in 1986, the facility encountered fierce community opposition and cost $350 million‍—‌$310 million more than the originally projected $40 million.

Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area in Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States. Unlike most other leading medical schools, HMS does not operate in conjunction with a single hospital but is directly affiliated with several teaching hospitals in the Boston area. Affiliated teaching hospitals and research institutes include Dana–Farber Cancer Institute, Massachusetts General Hospital, Brigham and Women's Hospital, Beth Israel Deaconess Medical Center, Boston Children's Hospital, McLean Hospital, Cambridge Health Alliance, The Baker Center for Children and Families, and Spaulding Rehabilitation Hospital.