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City Brewing Company is a large brewery located in La Crosse, Wisconsin, USA. It also goes by the trade name of City Brewery.

The Franciscan Sisters of Perpetual Adoration (FSPA) is a Roman Catholic religious congregation for women whose motherhouse, St. Rose of Viterbo Convent, is in La Crosse, Wisconsin, in the Diocese of La Crosse. The Franciscan Sisters of Perpetual Adoration founded Viterbo University and staffed Aquinas High School in La Crosse. The congregation traces its roots to 1849.

The Mons Anderson House is a historic house located at 410 Cass Street in La Crosse, Wisconsin.

Viterbo University is a private Catholic university in La Crosse, Wisconsin. Founded in 1890 by the Franciscan Sisters of Perpetual Adoration, Viterbo is home to three colleges with nine schools offering 48 academic programs at the associate, bachelor's, master's, and doctoral levels.Viterbo is one of 23 Franciscan universities in the United States, with 2,521 undergraduate and graduate students and over 23,000 alumni. As of 2020, Viterbo's endowment was a record $55.7 million. Viterbo is a member of the NAIA and the North Star Athletic Association; its athletic teams are known as the V-Hawks.

The Mississippi River Bridge is a combination of two individual bridges which are also known as the Cass Street Bridge and the Cameron Avenue Bridge, as well as the Big Blue Bridges. They connect downtown La Crosse, Wisconsin to Barron Island, crossing the east channel of the Mississippi River. Another bridge, the La Crosse West Channel Bridge connects Barron Island to La Crescent, Minnesota. The Mississippi River Bridge carries U.S. Routes 14 and 61 with WI 16. There is another bridge about four miles upstream, the I-90 Mississippi River Bridge that connects North La Crosse, French Island, and Dresbach, Minnesota. The Cass Street Bridge opened Sept. 23, 1939; replacing the previous Vernon Street swing bridge which was heavily damaged following an automobile accident in 1935. The original concrete deck was replaced by a metal deck in 1983; the deck was rehabilitated when the parallel Cameron Avenue Bridge opened in 2005.

The La Crosse Commercial Historic District is located in downtown La Crosse, Wisconsin. It includes over ninety contributing structures, mostly 2-3 story commercial brick buildings constructed from the 1860s to the 1940s. The district is roughly bounded by Jay Street, Second Street South, State Street, and Fifth Avenue South.Some of the notable contributing properties include the 1866 Voegle grocery and saloon, the 1870 Italianate Solberg grocery store, the 1894 Romanesque/Queen Anne Rehfuss dry goods building, the 1903 Chicago school Doerflinger department store, the 1920 Neoclassical Rivoli building and theatre, and the 1940 Moderne Hoeschler Exchange building.The district currently contains numerous bars and restaurants. Downtown La Crosse once had the Guinness Book record with the most bars/nightclubs located on one street, which was Third Street. The area also includes other shops, offices, and residential spaces. The NRHP listed Freight House is located two blocks north of the historic district.

The Cathedral of St. Joseph the Workman is the mother church of the Diocese of La Crosse. The cathedral, designed by architect Edward J. Schulte, was completed in 1962. Built of limestone, it has a tall clock tower which rises above the surrounding buildings in downtown La Crosse, Wisconsin.In 2008, the cathedral undertook a six-week project to repair the steeple. In March 2021, the cathedral began another program to repair the steeple which began to drop stones in summer 2020. The renovations will address several problem areas of the structure and are expected to be complete by year's end.The following Bishops of the Diocese of La Crosse are buried in the Blessed Sacrament Chapel: Kilian Caspar Flasch James Schwebach Alexander Joseph McGavick, founder of Aquinas High School-La Crosse, Wisconsin John Patrick Treacy, the builder of the new cathedral Frederick William Freking John Joseph PaulNote:Bishop Michael Heiss is buried in Milwaukee and Auxiliary Bishop William Richard Griffin is buried in Chicago.

St. Rose of Viterbo Convent is the motherhouse of the Franciscan Sisters of Perpetual Adoration, an American religious congregation, which is located in La Crosse, Wisconsin. The convent is dedicated to Rose of Viterbo, a 13th-century Franciscan tertiary who was a noted mystic and street preacher in Italy who died while still a teenager.The convent contains three chapels, of which one, Mary of the Angels Chapel, is listed on the National Register of Historic Places of the United States. Another, the Adoration Chapel, is the site of perpetual adoration of the Blessed Sacrament, was the site of 141 years of uninterrupted practice of the Sisters from August 1, 1878 to February 2020. The sisters continue to pray in shifts between 6 a.m. and 10 p.m.

Gundersen Health System (Gundersen Health) is a comprehensive non-profit health system based in La Crosse, Wisconsin. The system includes multi-specialty group medical practices, a teaching hospital, regional community clinics, affiliate hospitals and clinics, behavioral health services, vision centers, pharmacies, and air and ground ambulances.Gundersen Health's flagship hospital, Gundersen Lutheran Medical Center, is located in La Crosse and is a teaching hospital with 325 beds and a Level II Trauma and Emergency Center. The hospital received Healthgrades America's 50 Best Hospitals recognition in 2015 and 2017 placing it in the top 1% nationally. Additional awards include receiving the Healthgrades Distinguished Hospital Award-Clinical Excellence recognition eight years in a row from 2008 to 2015.Gundersen Lutheran is also a designated academic campus for the University of Wisconsin School of Medicine and Public Health.

The La Crosse Center is a multi-purpose arena in downtown La Crosse, Wisconsin, built in 1980. The arena can seat between 5,000 and 7,500, depending on the type of event. The center is also a convention center. In addition to the arena, which offers 21,600 square feet (2,010 m2) of exhibit space, two locker rooms, and three dressing rooms, there is 14,935-square-foot (1,388 m2) North Hall, which can open up to the arena to be used in combination; and a 38,740-square-foot (3,599 m2) South Exhibit Hall. All three venues total 75,275 square feet (6,993 m2) of exhibit space. The complex also contains 9,432 square feet (876 m2) of space in five meeting rooms, which can be divided into nine meeting rooms. While both exhibit halls and the arena are used for trade shows, conventions, meetings and banquets, the arena is also used for sporting events, concerts, circuses, ice shows, and other events.In addition, the center is home to countless exhibits and shows. One noteworthy event is the annual Bi-State Classic high school wrestling tournament. The center holds ten full-size wrestling mats and up to 55 wrestling squads. The most recent change to the La Crosse Center was a fifty-foot skywalk spanning over Second Street in downtown La Crosse. The skywalk links a five floor parking ramp with the east end of the convention center. The La Crosse Center is situated less than 300 feet (91.44 meters) from the banks of the Mississippi River, and Riverside Park in Downtown La Crosse.

Mayo Clinic Health System - Franciscan Healthcare is one of the two hospitals in La Crosse, Wisconsin. Franciscan Healthcare is part of the Mayo Clinic Health System This hospital has 142 beds and provides emergency services and an Intensive Care Unit.

La Crosse Public Library (La Crosse, Wisconsin) is the public library system in La Crosse, Wisconsin. The library serves as the resource library for the Winding Rivers Library System and the administrative offices for WRLS are at the public library. The library serves 50,000 people, has 245,000 volumes, and has 800,000 annual circulation transactions.In 2005, the La Crosse Public Library won an award for its digitized history website.