La Crosse Public Library (La Crosse, Wisconsin)

Christ Episcopal Church is a historic Episcopal church located in La Crosse, Wisconsin in the Episcopal Diocese of Eau Claire. In 1985, Christ Church was added to the National Register of Historic Places.

The Cathedral of St. Joseph the Workman is the mother church of the Diocese of La Crosse. The cathedral, designed by architect Edward J. Schulte, was completed in 1962. Built of limestone, it has a tall clock tower which rises above the surrounding buildings in downtown La Crosse, Wisconsin.In 2008, the cathedral undertook a six-week project to repair the steeple. In March 2021, the cathedral began another program to repair the steeple which began to drop stones in summer 2020. The renovations will address several problem areas of the structure and are expected to be complete by year's end.The following Bishops of the Diocese of La Crosse are buried in the Blessed Sacrament Chapel: Kilian Caspar Flasch James Schwebach Alexander Joseph McGavick, founder of Aquinas High School-La Crosse, Wisconsin John Patrick Treacy, the builder of the new cathedral Frederick William Freking John Joseph PaulNote:Bishop Michael Heiss is buried in Milwaukee and Auxiliary Bishop William Richard Griffin is buried in Chicago.

The Gideon C. Hixon House is a historic residence built in 1859 and located in La Crosse, Wisconsin. The house was built for Gideon Hixon, a partner in a lumber business. Hixon would later become a founder and president of the La Cross National Bank and would serve in the state legislature. The house was added to the National Register of Historic Places in 1974.

Aquinas High School is a Roman Catholic high school located in La Crosse, Wisconsin. The school is part of La Crosse Aquinas Catholic Schools and is operated by the Diocese of La Crosse. In 2008, Aquinas High School was named a national Blue Ribbon School.

The Mons Anderson House is a historic house located at 410 Cass Street in La Crosse, Wisconsin.

The La Crosse Commercial Historic District is located in downtown La Crosse, Wisconsin. It includes over ninety contributing structures, mostly 2-3 story commercial brick buildings constructed from the 1860s to the 1940s. The district is roughly bounded by Jay Street, Second Street South, State Street, and Fifth Avenue South.Some of the notable contributing properties include the 1866 Voegle grocery and saloon, the 1870 Italianate Solberg grocery store, the 1894 Romanesque/Queen Anne Rehfuss dry goods building, the 1903 Chicago school Doerflinger department store, the 1920 Neoclassical Rivoli building and theatre, and the 1940 Moderne Hoeschler Exchange building.The district currently contains numerous bars and restaurants. Downtown La Crosse once had the Guinness Book record with the most bars/nightclubs located on one street, which was Third Street. The area also includes other shops, offices, and residential spaces. The NRHP listed Freight House is located two blocks north of the historic district.

St. Rose of Viterbo Convent is the motherhouse of the Franciscan Sisters of Perpetual Adoration, an American religious congregation, which is located in La Crosse, Wisconsin. The convent is dedicated to Rose of Viterbo, a 13th-century Franciscan tertiary who was a noted mystic and street preacher in Italy who died while still a teenager.The convent contains three chapels, of which one, Mary of the Angels Chapel, is listed on the National Register of Historic Places of the United States. Another, the Adoration Chapel, is the site of perpetual adoration of the Blessed Sacrament, was the site of 141 years of uninterrupted practice of the Sisters from August 1, 1878 to February 2020. The sisters continue to pray in shifts between 6 a.m. and 10 p.m.

The Franciscan Sisters of Perpetual Adoration (FSPA) is a Roman Catholic religious congregation for women whose motherhouse, St. Rose of Viterbo Convent, is in La Crosse, Wisconsin, in the Diocese of La Crosse. The Franciscan Sisters of Perpetual Adoration founded Viterbo University and staffed Aquinas High School in La Crosse. The congregation traces its roots to 1849.

Mayo Clinic Health System - Franciscan Healthcare is one of the two hospitals in La Crosse, Wisconsin. Franciscan Healthcare is part of the Mayo Clinic Health System This hospital has 142 beds and provides emergency services and an Intensive Care Unit.

Viterbo University is a private Catholic university in La Crosse, Wisconsin. Founded in 1890 by the Franciscan Sisters of Perpetual Adoration, Viterbo is home to three colleges with nine schools offering 48 academic programs at the associate, bachelor's, master's, and doctoral levels.Viterbo is one of 23 Franciscan universities in the United States, with 2,521 undergraduate and graduate students and over 23,000 alumni. As of 2020, Viterbo's endowment was a record $55.7 million. Viterbo is a member of the NAIA and the North Star Athletic Association; its athletic teams are known as the V-Hawks.

The Freight House is a restaurant in downtown La Crosse, Wisconsin located close to the river front and Riverside Park. The building was a freight house built by the Chicago, Milwaukee and St. Paul Railway in 1880, with an addition in 1904. It was converted in 1978 into a restaurant. It is on the National Register of Historic Places.

La Crosse Aquinas Catholic Schools or ACS is a school district in La Crosse, Wisconsin and Onalaska, Wisconsin operated by the Roman Catholic Diocese of La Crosse. Previously known as Coulee Catholic Schools, the district changed its name in 2009 to Aquinas Catholic Schools.