Cathedral of Saint Joseph the Workman

La Crosse Public Library (La Crosse, Wisconsin) is the public library system in La Crosse, Wisconsin. The library serves as the resource library for the Winding Rivers Library System and the administrative offices for WRLS are at the public library. The library serves 50,000 people, has 245,000 volumes, and has 800,000 annual circulation transactions.In 2005, the La Crosse Public Library won an award for its digitized history website.

The Mons Anderson House is a historic house located at 410 Cass Street in La Crosse, Wisconsin.

The La Crosse Commercial Historic District is located in downtown La Crosse, Wisconsin. It includes over ninety contributing structures, mostly 2-3 story commercial brick buildings constructed from the 1860s to the 1940s. The district is roughly bounded by Jay Street, Second Street South, State Street, and Fifth Avenue South.Some of the notable contributing properties include the 1866 Voegle grocery and saloon, the 1870 Italianate Solberg grocery store, the 1894 Romanesque/Queen Anne Rehfuss dry goods building, the 1903 Chicago school Doerflinger department store, the 1920 Neoclassical Rivoli building and theatre, and the 1940 Moderne Hoeschler Exchange building.The district currently contains numerous bars and restaurants. Downtown La Crosse once had the Guinness Book record with the most bars/nightclubs located on one street, which was Third Street. The area also includes other shops, offices, and residential spaces. The NRHP listed Freight House is located two blocks north of the historic district.

Christ Episcopal Church is a historic Episcopal church located in La Crosse, Wisconsin in the Episcopal Diocese of Eau Claire. In 1985, Christ Church was added to the National Register of Historic Places.

The Gideon C. Hixon House is a historic residence built in 1859 and located in La Crosse, Wisconsin. The house was built for Gideon Hixon, a partner in a lumber business. Hixon would later become a founder and president of the La Cross National Bank and would serve in the state legislature. The house was added to the National Register of Historic Places in 1974.

The Freight House is a restaurant in downtown La Crosse, Wisconsin located close to the river front and Riverside Park. The building was a freight house built by the Chicago, Milwaukee and St. Paul Railway in 1880, with an addition in 1904. It was converted in 1978 into a restaurant. It is on the National Register of Historic Places.

The Franciscan Sisters of Perpetual Adoration (FSPA) is a Roman Catholic religious congregation for women whose motherhouse, St. Rose of Viterbo Convent, is in La Crosse, Wisconsin, in the Diocese of La Crosse. The Franciscan Sisters of Perpetual Adoration founded Viterbo University and staffed Aquinas High School in La Crosse. The congregation traces its roots to 1849.

The La Crosse Center is a multi-purpose arena in downtown La Crosse, Wisconsin, built in 1980. The arena can seat between 5,000 and 7,500, depending on the type of event. The center is also a convention center. In addition to the arena, which offers 21,600 square feet (2,010 m2) of exhibit space, two locker rooms, and three dressing rooms, there is 14,935-square-foot (1,388 m2) North Hall, which can open up to the arena to be used in combination; and a 38,740-square-foot (3,599 m2) South Exhibit Hall. All three venues total 75,275 square feet (6,993 m2) of exhibit space. The complex also contains 9,432 square feet (876 m2) of space in five meeting rooms, which can be divided into nine meeting rooms. While both exhibit halls and the arena are used for trade shows, conventions, meetings and banquets, the arena is also used for sporting events, concerts, circuses, ice shows, and other events.In addition, the center is home to countless exhibits and shows. One noteworthy event is the annual Bi-State Classic high school wrestling tournament. The center holds ten full-size wrestling mats and up to 55 wrestling squads. The most recent change to the La Crosse Center was a fifty-foot skywalk spanning over Second Street in downtown La Crosse. The skywalk links a five floor parking ramp with the east end of the convention center. The La Crosse Center is situated less than 300 feet (91.44 meters) from the banks of the Mississippi River, and Riverside Park in Downtown La Crosse.

Riverside Park is a public park located on the riverfront of downtown La Crosse, Wisconsin. It hosts events such as Riverfest, Fourth of July fireworks, Oktoberfest, Moon Tunes, and the Rotary Lights. The steamboats American Queen, La Crosse Queen, and Julia Belle Swain make stops along the river in the park. The park has walking/running trails.

St. Rose of Viterbo Convent is the motherhouse of the Franciscan Sisters of Perpetual Adoration, an American religious congregation, which is located in La Crosse, Wisconsin. The convent is dedicated to Rose of Viterbo, a 13th-century Franciscan tertiary who was a noted mystic and street preacher in Italy who died while still a teenager.The convent contains three chapels, of which one, Mary of the Angels Chapel, is listed on the National Register of Historic Places of the United States. Another, the Adoration Chapel, is the site of perpetual adoration of the Blessed Sacrament, was the site of 141 years of uninterrupted practice of the Sisters from August 1, 1878 to February 2020. The sisters continue to pray in shifts between 6 a.m. and 10 p.m.

Viterbo University is a private Catholic university in La Crosse, Wisconsin. Founded in 1890 by the Franciscan Sisters of Perpetual Adoration, Viterbo is home to three colleges with nine schools offering 48 academic programs at the associate, bachelor's, master's, and doctoral levels.Viterbo is one of 23 Franciscan universities in the United States, with 2,521 undergraduate and graduate students and over 23,000 alumni. As of 2020, Viterbo's endowment was a record $55.7 million. Viterbo is a member of the NAIA and the North Star Athletic Association; its athletic teams are known as the V-Hawks.

Aquinas High School is a Roman Catholic high school located in La Crosse, Wisconsin. The school is part of La Crosse Aquinas Catholic Schools and is operated by the Diocese of La Crosse. In 2008, Aquinas High School was named a national Blue Ribbon School.