Franciscan Skemp Medical Center

St. Rose of Viterbo Convent is the motherhouse of the Franciscan Sisters of Perpetual Adoration, an American religious congregation, which is located in La Crosse, Wisconsin. The convent is dedicated to Rose of Viterbo, a 13th-century Franciscan tertiary who was a noted mystic and street preacher in Italy who died while still a teenager.The convent contains three chapels, of which one, Mary of the Angels Chapel, is listed on the National Register of Historic Places of the United States. Another, the Adoration Chapel, is the site of perpetual adoration of the Blessed Sacrament, was the site of 141 years of uninterrupted practice of the Sisters from August 1, 1878 to February 2020. The sisters continue to pray in shifts between 6 a.m. and 10 p.m.

Viterbo University is a private Catholic university in La Crosse, Wisconsin. Founded in 1890 by the Franciscan Sisters of Perpetual Adoration, Viterbo is home to three colleges with nine schools offering 48 academic programs at the associate, bachelor's, master's, and doctoral levels.Viterbo is one of 23 Franciscan universities in the United States, with 2,521 undergraduate and graduate students and over 23,000 alumni. As of 2020, Viterbo's endowment was a record $55.7 million. Viterbo is a member of the NAIA and the North Star Athletic Association; its athletic teams are known as the V-Hawks.

Aquinas High School is a Roman Catholic high school located in La Crosse, Wisconsin. The school is part of La Crosse Aquinas Catholic Schools and is operated by the Diocese of La Crosse. In 2008, Aquinas High School was named a national Blue Ribbon School.

La Crosse Aquinas Catholic Schools or ACS is a school district in La Crosse, Wisconsin and Onalaska, Wisconsin operated by the Roman Catholic Diocese of La Crosse. Previously known as Coulee Catholic Schools, the district changed its name in 2009 to Aquinas Catholic Schools.

The Franciscan Sisters of Perpetual Adoration (FSPA) is a Roman Catholic religious congregation for women whose motherhouse, St. Rose of Viterbo Convent, is in La Crosse, Wisconsin, in the Diocese of La Crosse. The Franciscan Sisters of Perpetual Adoration founded Viterbo University and staffed Aquinas High School in La Crosse. The congregation traces its roots to 1849.

La Crosse Public Library (La Crosse, Wisconsin) is the public library system in La Crosse, Wisconsin. The library serves as the resource library for the Winding Rivers Library System and the administrative offices for WRLS are at the public library. The library serves 50,000 people, has 245,000 volumes, and has 800,000 annual circulation transactions.In 2005, the La Crosse Public Library won an award for its digitized history website.

Christ Episcopal Church is a historic Episcopal church located in La Crosse, Wisconsin in the Episcopal Diocese of Eau Claire. In 1985, Christ Church was added to the National Register of Historic Places.

The Cathedral of St. Joseph the Workman is the mother church of the Diocese of La Crosse. The cathedral, designed by architect Edward J. Schulte, was completed in 1962. Built of limestone, it has a tall clock tower which rises above the surrounding buildings in downtown La Crosse, Wisconsin.In 2008, the cathedral undertook a six-week project to repair the steeple. In March 2021, the cathedral began another program to repair the steeple which began to drop stones in summer 2020. The renovations will address several problem areas of the structure and are expected to be complete by year's end.The following Bishops of the Diocese of La Crosse are buried in the Blessed Sacrament Chapel: Kilian Caspar Flasch James Schwebach Alexander Joseph McGavick, founder of Aquinas High School-La Crosse, Wisconsin John Patrick Treacy, the builder of the new cathedral Frederick William Freking John Joseph PaulNote:Bishop Michael Heiss is buried in Milwaukee and Auxiliary Bishop William Richard Griffin is buried in Chicago.

Gund Brewery Lofts or the old Gund Brewing Company Bottling Works was a progressive beer-bottling factory built in 1903, designed by Louis Lehle with modern sanitization and pasteurization machines that gave Gund's beer a reliable shelf life, and electrical power that allowed an efficient plant layout. The factory has now been remodeled as apartments. It is now listed on the National Register of Historic Places.

The Mons Anderson House is a historic house located at 410 Cass Street in La Crosse, Wisconsin.

Gundersen Health System (Gundersen Health) is a comprehensive non-profit health system based in La Crosse, Wisconsin. The system includes multi-specialty group medical practices, a teaching hospital, regional community clinics, affiliate hospitals and clinics, behavioral health services, vision centers, pharmacies, and air and ground ambulances.Gundersen Health's flagship hospital, Gundersen Lutheran Medical Center, is located in La Crosse and is a teaching hospital with 325 beds and a Level II Trauma and Emergency Center. The hospital received Healthgrades America's 50 Best Hospitals recognition in 2015 and 2017 placing it in the top 1% nationally. Additional awards include receiving the Healthgrades Distinguished Hospital Award-Clinical Excellence recognition eight years in a row from 2008 to 2015.Gundersen Lutheran is also a designated academic campus for the University of Wisconsin School of Medicine and Public Health.

The World's Largest Six-Pack is a large collection of six beer storage tanks in La Crosse, Wisconsin. It is a well-known landmark and tourist attraction in the city. The cans can collectively hold about 688,200 US gal (2,605,000 L) of beer.