Houses of the Mayorazgo de Guerrero

The Museo Nacional de las Culturas (MNC; National Museum of Cultures) is a national museum in Mexico City dedicated to education about the world's cultures, both past and present. It is housed in a colonial-era building that used to be the mint for making coins. Prior to this, the site was the home of the location of the Moctezuma's Black House. The mint was moved to Apartado Street in 1850, and the building was used for various purposes until it was converted to its current use in 1966.

The Convent of Santa Inés was a convent in Mexico City from 1600 to 1861, later separated into the present day Church of Santa Inés and José Luis Cuevas Museum, located just off the Zócalo within the Historic center of Mexico City.

The Church of Santa Inés is a church located at 26 Moneda Street, just northeast of the Zócalo, Mexico City, Mexico. The building, formerly part of the Convent of Santa Inés, is considered to be a mix of styles between Mexican Baroque and Neoclassical. The church was completely finished in 1770.The church has two portals, one dedicated to Saint Agnes and the other to the Apostle James the Great. The wooden doors of this church are carved with reliefs. Some of these depict the life of Saint Agnes and others show images of the nuns of the convent with their benefactors, Don Diego Caballero and Doña Inés de Velasco. One scene depicts the life of the Apostle James just after he is martyred by decapitation. One other shows Santiago Matamoros, a saint connected with the expulsion of the Moors from Spain.Its dome is decorated with tiles laid in a strip design and made to look like rebozos, a type of indigenous shawl. Inside, the original Baroque altar is long gone, replaced with the current Neoclassic altar. Mexican painters Miguel Cabrera and José de Ibarra are interned in altar here.

Santa Teresa la Antigua is a former convent located in the historic center of Mexico City on Licenciado Primo de Verdad #6 just northeast of the city's main plaza. The complex ceased to be a convent in the latter part of the 19th century and has housed the Santa Teresa la Antigua Alternative Art Center since 1989.

The José Luis Cuevas Museum is located just off the Zócalo within the Historic center of Mexico City, in Mexico City, Mexico. The museum and Church of Santa Inés were built as parts of the Convent of Santa Inés (Agnes of Rome) complex. The museum is in the convent's colonial era residential hall.

The Faculty of Arts and Design (formerly known as the Escuela Nacional de Artes Plásticas or ENAP), is a college of art in Xochimilco, Mexico City. The school is part the Universidad Nacional Autónoma de México, and is responsible for teaching painting, sculpture and graphic design, with undergraduate and graduate studies in San Carlos. It is regarded as one of the best art schools in Mexico.

The city now known as Mexico City was founded as Mexico Tenochtitlan in 1325 and a century later became the dominant city-state of the Aztec Triple Alliance, formed in 1430 and composed of Tenochtitlan, Texcoco, and Tlacopan. At its height, Tenochtitlan had enormous temples and palaces, a huge ceremonial center, residences of political, religious, military, and merchants. Its population was estimated at least 100,000 and perhaps as high as 200,000 in 1519 when the Spaniards first saw it. During the final stage of the Spanish conquest of the Aztecs, Spanish forces besieged and razed Tenochtitlan. Hernán Cortés understood the strategic and symbolic importance of the Aztec capital, founded the Spanish capital of Mexico City on the site, and in particular rebuilt the Aztec ceremonial and political center as the main square, the Plaza Mayor, usually called the Zócalo. Some of the oldest structures in Mexico City date from the early conquest era. Many colonial-era buildings remain standing and have been re-purposed as government buildings and museums. As the seats of the Viceroyalty of New Spain and the Archbishopric of New Spain, Mexico City was the center not only of political and religious institutions but also of Mexico's economic activity and the residence of social elites in colonial Mexico (1521–1821). Great merchant houses were located here, and the economic elites of the country also lived in the city, even if the sources of their wealth lay elsewhere. The concentration of mansions and palaces in what is now the Mexico City historic center led it to be nicknamed the "City of Palaces", a sobriquet often attributed, perhaps erroneously, to great savant Alexander von Humboldt. It was also a major educational center: the University of Mexico was founded in 1553 as part of the complex of the Plaza Mayor. The crown-approved attempt to train Nahua men to become Christian priests saw the establishment in 1536 of the Colegio de Santa Cruz de Tlatelolco in one of the two sections of the capital governed by a Nahua city council (cabildo). Many religious institutions for the education of the sons of Spanish elites were also based in the capital. Mexico City had the colony's largest concentration of those of Spanish heritage (both Iberian-born peninsulares and American-born criollos), as well as the largest concentration of mixed race casta population in the colony. Many Indians also lived outside the center of the capital. Ever since independence in 1821, Mexico City remains the country's largest and most important city. Post-independence, U.S. forces captured Mexico City during the Mexican–American War, and the city saw violence during the Reform War and the French Intervention as well as the Mexican Revolution. At the beginning of the 20th century, the city's population stood at about 500,000. The city's history in the 20th and 21st centuries has been marked by explosive population growth and its accompanying problems. The city center deteriorated. The government has had problems keeping up with basic services, but the building of the Mexico City Metro has alleviated some major transportation problems. Smog became a serious problem as the shanty towns evolved, formed by the poor of the country migrating to the city. Since the 1985 Mexico City earthquake, which caused significant damage to the center of the city, efforts have been made to correct some of these problems. In the 2000s, businessman and philanthropist Carlos Slim created a foundation to revitalize the historic center as well as sites near the Basilica of the Virgin of Guadalupe.

The Academy of San Carlos (Spanish: Academia de San Carlos) is located at 22 Academia Street in just northeast of the main plaza of Mexico City. It was the first major art academy and the first art museum in the Americas. It was founded in 1781 as the School of Engraving and moved to the Academia Street location about 10 years later. It emphasized classical European training until the early 20th century, when it shifted to a more modern perspective. At this time, it also integrated with the National Autonomous University of Mexico, eventually becoming the Faculty of Arts and Design, which is based in Xochimilco. Currently, only graduate courses of the modern school are given in the original academy building.

The Palacio de la Autonomía (Autonomy Palace) is a museum and site where the Universidad Nacional Autónoma de México gained autonomy from direct government control in 1929. The building is from the late 19th century, and located on the corner of Licenciado de Verdad and Rep de Guatemala streets, north of Santa Teresa la Antigua and east of Templo Mayor. The site has a 500-year history, starting from part of lands granted by Hernán Cortés. The current building was constructed by the administration of President Porfirio Díaz, but it was ceded to the University in 1910. Since that time, the building has had a number of uses, including housing a dental school and a preparatory school. Today it houses the Museo de la Autonomía Universitaria (University Autonomy Museum).

The Museo de la Secretaría de Hacienda y Crédito Público is an art museum located in the historic center of Mexico City. It is housed in what was the Palacio del Arzobispado (Palace of the Archbishopric), built in 1530 under Friar Juan de Zumárraga on the base of the destroyed pyramid dedicated to the Aztec god Tezcatlipoca. It remained the archbishphoric until 1867 when the Finance Ministry Accountancy Department was established there. The modern museum houses an exhibit dedicated to this god as well as a large art collection.

The Fall of Tenochtitlan, the capital of the Aztec Empire, was a decisive event in the Spanish conquest of the empire. It occurred in 1521 following extensive manipulation of local factions and exploitation of pre-existing political divisions by Spanish conquistador Hernán Cortés. He was aided by indigenous allies, and his interpreter and companion La Malinche. Although numerous battles were fought between the Aztec Empire and the Spanish-led coalition, which was composed mainly of Tlaxcaltec men, it was the siege of Tenochtitlan that directly led to the downfall of the Aztec civilization and marked the end of the first phase of the Spanish conquest of the Aztec Empire. The Aztec population was devastated at the time by high mortality due to a smallpox epidemic, which killed much of its leadership. Because smallpox had been endemic in Asia and Europe for centuries, the Spanish had developed an acquired immunity and were affected relatively little in the epidemic. The conquest of Mexico was a critical stage in the Spanish colonization of the Americas. With this conquest, Spain gained substantial access to the Pacific Ocean. Through that, the Spanish Empire could finally achieve its original oceanic goal of reaching the Asian markets.

The Massacre in the Great Temple, also called the Alvarado Massacre, was an event on May 22, 1520, in the Aztec capital Tenochtitlan during the Spanish conquest of Mexico, in which the celebration of the Feast of Toxcatl ended in a massacre of Aztec elites. While Hernán Cortés was in Tenochtitlan, he heard about other Spaniards arriving on the coast – Pánfilo de Narváez had come from Cuba with orders to arrest him – and Cortés was forced to leave the city to fight them. During his absence, Moctezuma asked deputy governor Pedro de Alvarado for permission to celebrate Toxcatl (an Aztec festivity in honor of Tezcatlipoca, one of their main gods, which, as popular in Aztec culture, included human sacrifice, in this case of a young man). But after the festivities had started, Alvarado interrupted the celebration, killing all the warriors and noblemen who were celebrating inside the Great Temple. The few who managed to escape the massacre by climbing over the walls informed the community of the Spaniards' atrocity.The Spanish version of the incident claims the conquistadors intervened to prevent a ritual of human sacrifice in the Templo Mayor; the Aztec version says the Spaniards were enticed into action by the gold the Aztecs were wearing, prompting an Aztec rebellion against the orders of Moctezuma. While differing so on Alvarado's specific motive, both accounts are in basic agreement that the celebrants were unarmed and that the massacre was without warning and unprovoked. The Aztecs were already antagonistic towards the Spaniards for being inside their city and for holding Moctezuma under house arrest. When Cortés and his men, including those who had come under Narváez, returned, the Aztecs began full scale hostilities against the Spaniards. The Spaniards had no choice but to retreat from the city, which they did on what is called the Sad Night (La Noche Triste), losing most of their men, who were either killed in the battle or were captured and sacrificed.