Federal Land Bank Building

Bethel A.M.E. Church is a historic African Methodist Episcopal Church at 1528 Sumter Street in Columbia, South Carolina.It was built in 1921 and added to the National Register in 1982.

The James Petigru Boyce Chapel is a historic church building at 1306 Hampton Street in Columbia, South Carolina. It is a Greek Revival building built in 1859. A convention met here on December 17, 1860, whose delegates voted unanimously for South Carolina to secede from the United States, leading to the American Civil War. It was designated a National Historic Landmark as First Baptist Church, the role it played at the time. The building is part of the facilities complex of the First Baptist Church, Columbia- a Southern Baptist megachurch.

Prisma Health Baptist Hospital (Formerly Baptist Medical Center and Palmetto Health Baptist Columbia) is a 489-bed acute-care facility located at the intersection of Taylor and Marion Streets in Downtown Columbia, South Carolina. The hospital was established in 1914 as South Carolina Baptist Hospital by the South Carolina Baptist Convention after the widow of Dr. Augustus B. Knowlton, a prominent Columbia physician, asked the church to purchase the hospital, at that time a 70-bed facility on Marion St., that she and her husband started. Over the years, the hospital expanded and grew as additional services were offered. Baptist Columbia became part of the Baptist Healthcare System when a second Baptist hospital was built in Easley, South Carolina in 1958. In 1998, the two-hospital Baptist Healthcare System merged with Richland Memorial Hospital to form Palmetto Health, the largest healthcare system in South Carolina at the time. In 2017, Palmetto Health merged with the Greenville Hospital System to form Prisma Health and continues as the largest not-for profit hospital operator in South Carolina.

The Columbia Commercial Historic District encompasses a historically significant portion of the central business district of Columbia, South Carolina. It includes portions of three blocks of Main Street between Laurel and Hampton Streets, as well as individual buildings on adjacent streets. It includes the full length of Main Streets east side on these blocks, but only the central block (between Blanding and Taylor Streets) on the west side, extending slightly south of Taylor. This area best illustrates the city's commercial and economic growth for a century, from the end of the American Civil War to about 1963, with a broad diversity of architectural styles found in a small area.The district was added to the National Register of Historic Places in 2014, and has twice been enlarged. Nine of the district's 36 buildings are also individually listed.

Canal Dime Savings Bank, also known as Eckerd's Drug Store, is a historic bank building located at Columbia, South Carolina. It was built between 1892 and 1895, and is a three-story, Romanesque Revival style brick building with a granite façade and red barrel tile roof. The building was purchased by Eckerd's Drug Store in 1936.It was added to the National Register of Historic Places in 1980.

Kress Building is a historic commercial building located at Columbia, South Carolina across the street from the Columbia Museum of Art. It was built in 1934 by S. H. Kress & Co., and is a two-story, Art Deco style building faced with white terra cotta and colored terra cotta ornamentation. It features rounded storefront windows and cornice that contains the word "Kress" and surmounted by a stepped parapet.As of 2016, the bottom floor is a Brazilian Steakhouse and the 2nd floor houses apartments. A penthouse is planned for the roof. It was added to the National Register of Historic Places in 1979.

Tunnelvision is a 50 ft x 75 ft large trompe-l'œil painting, by Blue Sky, on a building in Columbia, South Carolina, USA, which shows a tunnel in original size. Tunnelvision looks very realistic.

Sylvan Building, originally known as Central National Bank, is a historic commercial building located at Columbia, South Carolina. It was built in 1870, and is a three-story, brick Second Empire style building designed by Samuel Sloan. It features a slate-covered mansard roof.It was added to the National Register of Historic Places in 1972.

Efird's Department Store, also known as Lourie's Department Store, is a historic department store building located at Columbia, South Carolina. It was built about 1870, and is a rectangular brick building renovated and expanded in 1919. This included the addition of a third story and the installation of a new brick façade and store entrances. Between 1919 and 1958, it housed the Columbia branch of the Charlotte, North Carolina based Efird's Department Store chain. It currently houses a Mast General Store, which moved in on May 25, 2011. It was added to the National Register of Historic Places in 2012.

The Columbia Museum of Art is an art museum in the American city of Columbia, South Carolina.

The Greyhound Bus Depot is a former Greyhound Lines intercity bus station in Columbia, South Carolina. It is at 1200 Blanding Street in downtown Columbia. The depot was named to the National Register of Historic Places on December 28, 1989. After the bus terminal was closed, the building became a bank. Currently, it is a physician's office.

The Palmetto Building, built during 1912–1913, is an early skyscraper in Columbia, South Carolina. It was designed by architect Julius Harder, and Wilson and Sompayrac served as supervising architects. Upon completion it was the tallest building in South Carolina.The Palmetto Building was listed on the National Register of Historic Places in 1980. Since the mid-2000s, it has housed the Sheraton Columbia Downtown Hotel.It was important in the architectural career of Charles Coker Wilson, establishing his credentials for steel frame skyscraper construction.