40th Street station (Market–Frankford Line)

The Philadelphia Ronald McDonald House was the first of the Ronald McDonald House Charities and now stands at 39th and Chestnut Streets in West Philadelphia.

Bell Telephone Exchange Building, also known as the Preston Telephone Exchange, is a historic telephone exchange located in the Powelton Village neighborhood of Philadelphia, Pennsylvania. It was built about 1900, by the Bell Telephone Company. It is a three-story, five bay, brick building on a raised basement and once set within a set of rowhouses. It is in the Georgian Revival style. It features an arched entrance and decorative cornice above the second story. It was used as a telephone exchange until 1928.It was added to the National Register of Historic Places in 2002.

The Pennsylvania Hotel, now known as Chestnut Hall, was designed by Clarence E. Wunder, and built in 1922. Wunder is also responsible for designing Bonwit Teller at 1700 Walnut St (in 1927) and the Neuweiler Brewery (in 1913). The 10-story building's architectural style is Renaissance revival. The building consists of a steel structure, a cement and brick facade, and an entablature with accompanying cornice along the top. Once built, the building served as the Hotel Pennsylvania. In the 1940s it became known as the Hotel Philadelphia. Throughout the 1950s and 1960s, it was known as the Penn Sherwood Hotel. In June 2006 Apartment Investment and Management Company (Aimco) bought a majority stake of the property.

Penn Presbyterian Medical Center ("Presby") is a hospital located in the University City section of West Philadelphia. It was founded by Reverend Ephraim D. Saunders in 1871 and formally joined the University of Pennsylvania Health System in 1995. Penn Presbyterian is spread out on a campus bounded by Market Street, Powelton Avenue, 38th Street, and Sloan Street.

Saunders Park is a neighborhood in the West Philadelphia section of Philadelphia, Pennsylvania. It is bounded by Powelton Avenue, 38th Street, Lancaster Avenue, and 40th Street. It is west of Powelton Village and north of Spruce Hill. It is named for the park at the northeast corner of 39th and Powelton Avenue. The Penn Presbyterian Medical Center is next to the park. Saunders Park is often considered to be a part of West Powelton, which extends out to 42nd Street. The neighborhood has participated in planning for its future with the Delaware Valley Regional Planning Commission. The report of that plan is available here.

Paul Robeson High School for Human Services is a district-run high school in Philadelphia with citywide admissions. The school is one of eight schools in the country that offers a focus in the human services field. The school is named after Paul Robeson.As part of Philadelphia's shutdown of 23 district-run schools in 2013, some displaced students from University City High School were relocated to Paul Robeson High School for Human Services.

Philadelphia Episcopal Cathedral, located at 38th and Chestnut Streets in West Philadelphia, is the cathedral church of the Episcopal Diocese of Pennsylvania. Formerly known as the Protestant Episcopal Church of the Saviour, it was built in 1855, renovated in 1898, and rebuilt in the year 1906, after an April 16, 1902 fire. In 1992 it became the seat of the Episcopal Diocese of Pennsylvania.The building was added to the National Register of Historic Places in 1979.

Chestnut Cabaret was a nightclub located at 38th & Ludlow Streets in Philadelphia, Pennsylvania. It was later named the Blockley before its closure in 2013.

Black Bottom was a predominantly African American and poor neighborhood in West Philadelphia, Pennsylvania. It was mostly razed for urban renewal in the 1960s.

St. Agatha–St. James Church (formerly St. James Church) is a Roman Catholic church in Philadelphia, Pennsylvania, established in 1850. As the first Roman Catholic parish in Philadelphia west of the Schuylkil River, St. Agatha-St. James Church is the mother church of West Philadelphia. Originally, a small church dedicated to St James the Greater was constructed in an open field at 38th and Chestnut Streets (then known as Mary and James Streets), but with the rapid influx of Catholics into the area, particularly from Ireland, the decision was made to build a larger church on the same land. Construction of the current building, designed by Philadelphia architect Edwin Forrest Durang, began on October 16, 1881 and was completed on the same day in 1887. The hand-carved wooden confessionals from the original 1850 church were placed in the new building and remain to this day. The name of the parish was changed to St Agatha-St James in 1976, following a merger with the nearby St. Agatha's Church (at 38th and Spring Garden Streets in Powelton Village). The old St Agatha's Church had suffered multiple fires, which coupled with the decline in the parish population, precipitated the decision to merge the two parishes. The current church has undergone various renovations over its history. The original structure featured strikingly asymmetrical towers, with the left tower having a circular profile and conical pinnacle. In 1930, the circular tower was reprofiled to match the square tower on the right side of the church, producing the symmetrical profile that is seen today. At the same time, electrical lighting was added to the interior of the church for the first time. A further renovation occurred in 2003, with the interior repainted in a simpler and less colorful design. The traditional altar rail was removed, and a large ambo was installed. In 2018-2019, the lower level of the church was renovated into a cafeteria and events space, the old school building was renovated to serve as a student ministry and office space, and link was built connecting the church to the old school building. A three-story pariochial school was built behind the church during the 1920s. The school remained in operation for several decades before closing in the 1970s due to declining enrollment. For a time, the old school building was leased as office space to the University of Pennsylvania. In 2019, the old school building was further renovated and became the home of the Newman Centers for both the University of Pennsylvania and Drexel University, following the sale of the former Newman Center building next door. The Newman Center at the University of Pennsylvania, founded in 1893 as the first such community inspired by St John Henry Newman, had operated independently of the parish sinch inception, despite being located next door since 1970. In 2010, the Newman Center was merged with the parish following the sale of the building at 33 S 33rd St with had housed Drexel Newman Center (established 1921), placing all three entities under the same leadership for the first time. In 2014, then-Archbishop Charles Chaput invited the Sodalitium Christianae Vitae (SCV), a society of apostolic life based in Peru commonly referred to as the Sodalits, to operate the combined parish and Newman community. St Agatha-St James is just to second house for the Sodalits in the United States, the first being located in Denver. The Sodalits continues to operate the parish, and the current pastor is Father Carlos Keen.

The University of Pennsylvania School of Dental Medicine (often referred to as Penn Dental Medicine or simply Penn Dental) is the dental school of the University of Pennsylvania (Penn), an Ivy League university located in Philadelphia. It is one of twelve graduate schools at Penn and one of several dental schools in Pennsylvania. It is part of the University of Pennsylvania Health System.

Pennsylvania Railroad Freight Building is a historic freight station, warehouse and showroom building located in the University City neighborhood of Philadelphia, Pennsylvania. It was built by the Pennsylvania Railroad in 1929, and is a six-story, flat roofed building in the Art Deco style. The first floor is clad in limestone and the upper stories are of buff-colored brick. Each floor contains approximately 88,000 square feet.From 1956 to 1993, it was the GE Re-entry Systems facility, where "thousands of engineers and technicians who solved the problem of vehicles successfully reentering the Earth's atmosphere" for NASA. Among the achievements of the men and women working at the facility is "the recovery of the first man-made object from orbit," a unique milestone for humanity. Generations of University of Pennsylvania and Drexel University students who worked there know it as "The GE Building". For this work, The American Institute of Aeronautics and Astronautics (AIAA) designated it as an Historic Aerospace Site in 2007.The building has been converted to residential use and is now known as the Left Bank. It was added to the National Register of Historic Places in 1999.