Chestnut Hall

The Philadelphia Ronald McDonald House was the first of the Ronald McDonald House Charities and now stands at 39th and Chestnut Streets in West Philadelphia.

Pennsylvania Railroad Freight Building is a historic freight station, warehouse and showroom building located in the University City neighborhood of Philadelphia, Pennsylvania. It was built by the Pennsylvania Railroad in 1929, and is a six-story, flat roofed building in the Art Deco style. The first floor is clad in limestone and the upper stories are of buff-colored brick. Each floor contains approximately 88,000 square feet.From 1956 to 1993, it was the GE Re-entry Systems facility, where "thousands of engineers and technicians who solved the problem of vehicles successfully reentering the Earth's atmosphere" for NASA. Among the achievements of the men and women working at the facility is "the recovery of the first man-made object from orbit," a unique milestone for humanity. Generations of University of Pennsylvania and Drexel University students who worked there know it as "The GE Building". For this work, The American Institute of Aeronautics and Astronautics (AIAA) designated it as an Historic Aerospace Site in 2007.The building has been converted to residential use and is now known as the Left Bank. It was added to the National Register of Historic Places in 1999.

Philadelphia Episcopal Cathedral, located at 38th and Chestnut Streets in West Philadelphia, is the cathedral church of the Episcopal Diocese of Pennsylvania. Formerly known as the Protestant Episcopal Church of the Saviour, it was built in 1855, renovated in 1898, and rebuilt in the year 1906, after an April 16, 1902 fire. In 1992 it became the seat of the Episcopal Diocese of Pennsylvania.The building was added to the National Register of Historic Places in 1979.

Chestnut Cabaret was a nightclub located at 38th & Ludlow Streets in Philadelphia, Pennsylvania. It was later named the Blockley before its closure in 2013.

University City is the easternmost portion of West Philadelphia, encompassing several Philadelphia universities. It is situated directly across the Schuylkill River from Center City. The University of Pennsylvania was instrumental in coining the name "University City" as part of a 1950s urban renewal and gentrification effort. University City is also home to Drexel University and the University City campus of Saint Joseph's University. The eastern side of University City contains the Penn and Drexel campuses, several medical institutions, independent centers of scientific research, 30th Street Station, Cira Centre, and Cira Centre South. The western side contains Victorian and early 20th-century housing stock and is primarily residential.

St. Agatha–St. James Church (formerly St. James Church) is a Roman Catholic church in Philadelphia, Pennsylvania, established in 1850. As the first Roman Catholic parish in Philadelphia west of the Schuylkil River, St. Agatha-St. James Church is the mother church of West Philadelphia. Originally, a small church dedicated to St James the Greater was constructed in an open field at 38th and Chestnut Streets (then known as Mary and James Streets), but with the rapid influx of Catholics into the area, particularly from Ireland, the decision was made to build a larger church on the same land. Construction of the current building, designed by Philadelphia architect Edwin Forrest Durang, began on October 16, 1881 and was completed on the same day in 1887. The hand-carved wooden confessionals from the original 1850 church were placed in the new building and remain to this day. The name of the parish was changed to St Agatha-St James in 1976, following a merger with the nearby St. Agatha's Church (at 38th and Spring Garden Streets in Powelton Village). The old St Agatha's Church had suffered multiple fires, which coupled with the decline in the parish population, precipitated the decision to merge the two parishes. The current church has undergone various renovations over its history. The original structure featured strikingly asymmetrical towers, with the left tower having a circular profile and conical pinnacle. In 1930, the circular tower was reprofiled to match the square tower on the right side of the church, producing the symmetrical profile that is seen today. At the same time, electrical lighting was added to the interior of the church for the first time. A further renovation occurred in 2003, with the interior repainted in a simpler and less colorful design. The traditional altar rail was removed, and a large ambo was installed. In 2018-2019, the lower level of the church was renovated into a cafeteria and events space, the old school building was renovated to serve as a student ministry and office space, and link was built connecting the church to the old school building. A three-story pariochial school was built behind the church during the 1920s. The school remained in operation for several decades before closing in the 1970s due to declining enrollment. For a time, the old school building was leased as office space to the University of Pennsylvania. In 2019, the old school building was further renovated and became the home of the Newman Centers for both the University of Pennsylvania and Drexel University, following the sale of the former Newman Center building next door. The Newman Center at the University of Pennsylvania, founded in 1893 as the first such community inspired by St John Henry Newman, had operated independently of the parish sinch inception, despite being located next door since 1970. In 2010, the Newman Center was merged with the parish following the sale of the building at 33 S 33rd St with had housed Drexel Newman Center (established 1921), placing all three entities under the same leadership for the first time. In 2014, then-Archbishop Charles Chaput invited the Sodalitium Christianae Vitae (SCV), a society of apostolic life based in Peru commonly referred to as the Sodalits, to operate the combined parish and Newman community. St Agatha-St James is just to second house for the Sodalits in the United States, the first being located in Denver. The Sodalits continues to operate the parish, and the current pastor is Father Carlos Keen.

40th Street station is an underground station on the SEPTA Market-Frankford Line, located the intersection of 40th Street and Market Street in Philadelphia, Pennsylvania, on the line between the Spruce Hill and Powelton Village neighborhoods in the University City District of West Philadelphia. The station serves a major shopping corridor of West Philadelphia on 40th Street, as well as the campus of the University of Pennsylvania, which lies three blocks south of the station. The station is served by SEPTA City Bus routes 30, 40 and LUCY. The station also serves as the inbound terminal for the SEPTA subway-surface trolley lines when services are diverted from the Market Street tunnels –– on Mondays from 12:00 a.m. to 5:00 a.m. and during any other unforeseen circumstances. All five trolley routes terminate at the intersection 40th Street and Market Street, just outside entrances to the Market–Frankford platforms.

St. Mary’s Church, Hamilton Village, is an Episcopal Church located on the University of Pennsylvania campus in Philadelphia, Pennsylvania. It calls itself the Episcopal Church at Penn to emphasize its campus ministry. The parish is part of the Episcopal Church in the Diocese of Pennsylvania. In 2020, it reported 225 members, 51 average attendance, and plate and pledge financial support of $95,097. The church is a remnant of the Hamilton Village neighborhood that existed in West Philadelphia prior to being subsumed by the University. The land was given to the church by the Hamilton family for whom the town was named.

Established in 1999, Neighborhood Bike Works (NBW) is a nonprofit educational organization in West Philadelphia. The mission of NBW is to inspire youth and strengthen Philadelphia communities by providing equitable access to bicycling and bike repair through education, recreation, leadership and career-building opportunities.

The Wharton School of the University of Pennsylvania ( WHOR-tən; also known as Wharton Business School, the Wharton School, and Wharton) is the business school of the University of Pennsylvania, a private Ivy League research university in Philadelphia, Pennsylvania. Generally considered to be one of the most prestigious business schools in the world, the Wharton School is the world's oldest collegiate business school, having been established in 1881 through a donation from Joseph Wharton.The Wharton School awards the Bachelor of Science with a school-specific economics concentration, and Bachelor of Arts degrees focusing on core management, general business, and international studies at the undergraduate level. At the graduate level, the Master of Business Administration (MBA) program offers dual studies leading to a joint degree from other schools (e.g., law, engineering, government). Similarly, in addition to its tracks in accounting, finance, operations, statistics and more, the doctoral program co-sponsors several diploma programs in conjunction with other schools within the University. The college was a pioneer in so-called 'Executive Education'; custom learning experiences that lead to academic enrichment, however with no standing. Since the establishment of journalistic rankings, Wharton's graduate program has been consistently ranked in the top tier. Its MBA program is ranked No. 1 in the World according to the Financial Times and No. 1 in the United States according to the 2023 U.S. News & World Report ranking. Meanwhile, Wharton's MBA for Executives and undergraduate programs are ranked No. 2 and No. 1 in the United States respectively by U.S. News. MBA graduates of Wharton earn an average $159,815 first year base pay not including bonuses, the highest of all the leading schools. Wharton's MBA program is tied for the highest in the United States with an average GMAT score of 732 (97th percentile) for its entering class.Wharton School alumni include former U.S. President Donald Trump, SpaceX founder Elon Musk, and billionaire investor Warren Buffett. Current and former CEOs of Fortune 500 companies including Alphabet Inc., General Electric, Boeing, Pfizer, Comcast, Oracle, PepsiCo and Johnson & Johnson are also Wharton School alumni.

The University of Pennsylvania School of Dental Medicine (often referred to as Penn Dental Medicine or simply Penn Dental) is the dental school of the University of Pennsylvania (Penn), an Ivy League university located in Philadelphia. It is one of twelve graduate schools at Penn and one of several dental schools in Pennsylvania. It is part of the University of Pennsylvania Health System.

Penn Presbyterian Medical Center ("Presby") is a hospital located in the University City section of West Philadelphia. It was founded by Reverend Ephraim D. Saunders in 1871 and formally joined the University of Pennsylvania Health System in 1995. Penn Presbyterian is spread out on a campus bounded by Market Street, Powelton Avenue, 38th Street, and Sloan Street.