Jefferson College of Health Sciences

St. John's Episcopal Church is a historic Episcopal church in Roanoke, Virginia, United States. It was built in 1891–1892, and is a Gothic style limestone church designed by Charles M. Burns of Philadelphia. The building is a nave-plan, clerestory-style church that includes a corner bell tower and a narthex and chapel in the rear. A Tudor Revival style parish house was constructed in 1923. The church's congregation is one of the city's oldest, and has included many prominent local, state, and national leaders. The church was listed on the National Register of Historic Places in 1991.

Virginia Can Company-S.H. Heironimus Warehouse is a historic factory and warehouse complex located at Roanoke, Virginia. The U-shaped complex was built in 1912, and consists of an office and two factory buildings. All three of the buildings are two stories in height and are constructed of brick on a raised foundation of poured concrete. A second-story pedestrian bridge connects the two factory buildings and a brick hyphen connects the office building to the north factory building. The complex was built for the Virginia Can Company, the first and largest manufacturer of tin cans in Roanoke, Virginia. After 1951, it housed a clothing factory and then the Heironimus department store warehouse.It was listed on the National Register of Historic Places in 2006, and included in the Roanoke River and Railroad Historic District in 2013. It is located in the Virginia Landmarks Register listed Southeast Roanoke Historic District.

USS Roanoke (CL-145) was the second ship of the Worcester-class light cruisers completed for the U.S. Navy shortly after the end of World War II. Commissioned in 1949, she served in the Atlantic, Mediterranean and Pacific before being decommissioned in 1958. She was sold for scrap in 1972.

The Patrick Henry Hotel is a Colonial Revival former hotel listed on both the National Register of Historic Places and the Virginia Landmarks Register in Downtown Roanoke, Virginia, United States. Located at 617 South Jefferson Street at the southern end of Downtown, the Patrick Henry was designed by William Lee Stoddart and opened in 1925. The building now serves as apartments, office space, and a restaurant in the former lobby rebranded simply The Patrick Henry. It is located in the Roanoke Downtown Historic District.

Old Southwest is a neighborhood of the independent city of Roanoke, Virginia, United States. Located geographically near the center of the city, Old Southwest was annexed from Roanoke County in 1890 and developed as one of Roanoke's more affluent residential areas. Today the majority of the neighborhood falls within the Southwest Historic District listed on both the Virginia Landmarks Register and the National Register of Historic Places.

The Boxley Building is a historic commercial building located in Roanoke, Virginia. It was built in 1922, during a wave of post-World War I construction in the city. The building is eight stories, and follows a pattern set by other skyscrapers of the time in consisting of three sections similar to a classical column. The bottom section, or pedestal, is one story fronted with granite; the middle section, or shaft, consists of the next six stories built with beige enameled brick; the top section, or capital, is the eighth story fronted with richly decorated terra cotta panels topped with a finely detailed copper cornice.The building was commissioned by William Wise Boxley, a local builder and developer who was Roanoke's mayor at the time of construction. Boxley was an influential figure in the city, having played a significant role in the founding of the Shenandoah Life Insurance Company and Colonial American Bank as well as sitting on the boards of both Roanoke College and Virginia Military Institute. Boxley was elected to the Roanoke City Council in 1918, and the following year was appointed the city's first mayor under its new council-manager form of government.: 552  The building's architect was Edward G. Frye, whose firm had previously erected the Roanoke Times building, the city's municipal building, and would complete Roanoke's new market building in the same year as the Boxley.: 500, 504, 586 Boxley's building materials company was one of the original tenants of the building, and remained headquartered there until vacating in 2005. The building was empty from the late-2000s until being purchased by a local developer in 2016. The building's offices were converted into residential space, with the bottom four floors used as dormitory housing for international students of two Roanoke-area parochial schools, and the top four floors converted into luxury apartments.The building was listed on the National Register of Historic Places in 1984, and it is a contributing structure to the Roanoke Downtown Historic District.

Fire Station No. 1 is a former fire station listed on the National Register of Historic Places in the Downtown neighborhood of the independent city of Roanoke, Virginia, United States. Modeled after Philadelphia's Independence Hall, Fire Station No. 1 served as one of the longest continuously operating fire stations in the Commonwealth of Virginia from its completion in 1907 through the opening of a replacement facility in 2007. Designed by the Lynchburg firm of Huggins and Bates, No. 1 still stands as a monument to the civic pride of early Roanoke. It is located in the Roanoke City Market Historic District.

Beth Israel Synagogue (Hebrew: בית ישראל) is a Conservative synagogue located at 920 Franklin Road in Roanoke, Virginia, in the United States. The synagogue was founded in 1900, and as of 2009, it had a membership of approximately 160 families and individuals.The 1925 building, designed by Frye and Stone, combines Classical Revival features in an unusual and rather severe design. A two-story Ionic portico, with an entablature, is engaged with and centered on the stepped gabled and parapeted façade. Doors and windows occupy each of the bays between the columns. A small Star of David occupies the gable.In 2007 the synagogue completed an expansion and renovation of its building, carefully planned so that the original facade, part of Roanoke's Old Southwest historic district, was unaltered.Rabbi Fabian Werbin commenced in 2008.

The Virginian Railway Passenger Station, also known as the Virginian Station is a former rail station listed on the National Register of Historic Places in the South Jefferson neighborhood of the independent city of Roanoke, Virginia, U.S.A. Located at the intersection of Jefferson Street SE (VA 116) and Williamson Road, the Virginian Station served as a passenger station for the Virginian Railway between 1910 and 1956. The station was the only station constructed with brick along the entire length of the Virginian's 608 miles (978 km) network. It was severely damaged by fire on January 29, 2001.

Roanoke ( ROH-ə-nohk) is an independent city in the U.S. state of Virginia. It is located in Southwest Virginia along the Roanoke River, in the Blue Ridge range of the greater Appalachian Mountains. Roanoke is approximately 50 miles (80 km) north of the Virginia–North Carolina border and 250 miles (400 km) southwest of Washington, D.C., along Interstate 81. At the 2020 census, Roanoke's population was 100,011, making it the largest city in Virginia west of the state capital Richmond. It is the primary population center of the Roanoke metropolitan area, which had a population of 315,251 in 2020. The Roanoke Valley was originally home to members of the Siouan-speaking Tutelo tribe. However, in the 17th and early-to-mid 18th centuries, Scotch-Irish and later German American farmers gradually drove those Native Americans out of the area as the American frontier pressed westward. In 1882, the Norfolk and Western Railway (N&W) chose the small town of Big Lick as the site of its corporate headquarters and railroad shops. Within two years, the town had become the City of Roanoke. With a 2,300% population growth rate in the decade from 1880 to 1890, the young city experienced the advantages and disadvantages of its boomtown status. During the 20th century, Roanoke's boundaries expanded through multiple annexations from the surrounding Roanoke County, and it became Southwest Virginia's economic and cultural hub. The 1982 decision by N&W to relocate their headquarters out of the city, combined with other manufacturing closures, led Roanoke to pivot to a primarily service economy. In the 21st century, a robust healthcare industry and the development and increased marketing of its outdoor amenities have helped reverse prior declining population trends. Roanoke is known for the Roanoke Star, an 88.5-foot-tall (27.0 m) illuminated star that sits atop a mountain within the city's limits and is the origin of its nickname, "The Star City of the South". Other points of interest include the Hotel Roanoke, a 330-room Tudor Revival structure built by N&W in 1882, the Taubman Museum of Art, designed by architect Randall Stout, and the city's farmer's market, the oldest continuously operating open-air market in the state. The Roanoke Valley features 26 miles of greenways with bicycle and pedestrian trails, and the city's location in the Blue Ridge Mountains provides access to numerous outdoor recreation opportunities.

Carilion Roanoke Memorial Hospital (CRMH) is a private teaching hospital in Roanoke, Virginia, USA. With 703 beds, Carilion Roanoke Memorial Hospital is one of the largest hospitals in the state. It is part of Carilion Clinic.The region's only level I trauma center, the hospital operates three medical helicopters (LifeGuard 10, 11, and 12) to provide air ambulance transport, including one in Moneta, one in Christiansburg, and one in Lexington.

The Roanoke Downtown Historic District is a national historic district located in the Downtown Roanoke area of Roanoke, Virginia. It encompasses 122 contributing buildings. It includes a variety of commercial, institutional, social, and governmental buildings and structures from the late 19th century to the mid-20th century. Notable buildings include the Roanoke City Public Library, the YMCA Central Branch Building, First Christian Church (1925), the Central Church of the Brethren (1924), Tomnes Cawley Funeral Home (1928), Thomas B. Mason Building (1961), Peerless Candy Co. (c. 1916), City Hall / Municipal Building (1915), Roanoke Times Building (1892), Anchor Building / Shenandoah Building (1910), Greene Memorial Methodist Church (1890), and United States Post Office and Courthouse (1930). Located in the district are the separately listed Patrick Henry Hotel, Boxley Building, Campbell Avenue Complex Historic District, Colonial National Bank, and First National Bank.It was listed on the National Register of Historic Places in 2002.