Virginia Can Company-S.H. Heironimus Warehouse

Jefferson College of Health Sciences (JCHS and Jefferson College) was a private health sciences college in Roanoke, Virginia. Officially chartered as a college in 1982, Jefferson College is the oldest hospital-based college in Virginia. In 2019, the college merged with Radford University to become Radford University Carilion. Jefferson College of Health Sciences had approximately 1,062 students based on the enrollment statistics from fall 2015 (81% female, 19% male) who represented approximately 31 states. The college offered 15 majors in various healthcare disciplines. Jefferson College of Health Sciences awarded the Associate of Science, Bachelor of Science, Master of Science and Doctoral degrees.

St. John's Episcopal Church is a historic Episcopal church in Roanoke, Virginia, United States. It was built in 1891–1892, and is a Gothic style limestone church designed by Charles M. Burns of Philadelphia. The building is a nave-plan, clerestory-style church that includes a corner bell tower and a narthex and chapel in the rear. A Tudor Revival style parish house was constructed in 1923. The church's congregation is one of the city's oldest, and has included many prominent local, state, and national leaders. The church was listed on the National Register of Historic Places in 1991.

USS Roanoke (CL-145) was the second ship of the Worcester-class light cruisers completed for the U.S. Navy shortly after the end of World War II. Commissioned in 1949, she served in the Atlantic, Mediterranean and Pacific before being decommissioned in 1958. She was sold for scrap in 1972.

The Patrick Henry Hotel is a Colonial Revival former hotel listed on both the National Register of Historic Places and the Virginia Landmarks Register in Downtown Roanoke, Virginia, United States. Located at 617 South Jefferson Street at the southern end of Downtown, the Patrick Henry was designed by William Lee Stoddart and opened in 1925. The building now serves as apartments, office space, and a restaurant in the former lobby rebranded simply The Patrick Henry. It is located in the Roanoke Downtown Historic District.

The Boxley Building is a historic commercial building located in Roanoke, Virginia. It was built in 1922, during a wave of post-World War I construction in the city. The building is eight stories, and follows a pattern set by other skyscrapers of the time in consisting of three sections similar to a classical column. The bottom section, or pedestal, is one story fronted with granite; the middle section, or shaft, consists of the next six stories built with beige enameled brick; the top section, or capital, is the eighth story fronted with richly decorated terra cotta panels topped with a finely detailed copper cornice.The building was commissioned by William Wise Boxley, a local builder and developer who was Roanoke's mayor at the time of construction. Boxley was an influential figure in the city, having played a significant role in the founding of the Shenandoah Life Insurance Company and Colonial American Bank as well as sitting on the boards of both Roanoke College and Virginia Military Institute. Boxley was elected to the Roanoke City Council in 1918, and the following year was appointed the city's first mayor under its new council-manager form of government.: 552  The building's architect was Edward G. Frye, whose firm had previously erected the Roanoke Times building, the city's municipal building, and would complete Roanoke's new market building in the same year as the Boxley.: 500, 504, 586 Boxley's building materials company was one of the original tenants of the building, and remained headquartered there until vacating in 2005. The building was empty from the late-2000s until being purchased by a local developer in 2016. The building's offices were converted into residential space, with the bottom four floors used as dormitory housing for international students of two Roanoke-area parochial schools, and the top four floors converted into luxury apartments.The building was listed on the National Register of Historic Places in 1984, and it is a contributing structure to the Roanoke Downtown Historic District.

Fire Station No. 1 is a former fire station listed on the National Register of Historic Places in the Downtown neighborhood of the independent city of Roanoke, Virginia, United States. Modeled after Philadelphia's Independence Hall, Fire Station No. 1 served as one of the longest continuously operating fire stations in the Commonwealth of Virginia from its completion in 1907 through the opening of a replacement facility in 2007. Designed by the Lynchburg firm of Huggins and Bates, No. 1 still stands as a monument to the civic pride of early Roanoke. It is located in the Roanoke City Market Historic District.

The Roanoke Valley ( ROH-ə-nohk) in southwest Virginia is an area adjacent to and including the Roanoke River between the Blue Ridge Mountains to the east and the Appalachian Plateau to the west. The valley includes much of Roanoke County, as well as the two independent cities of Roanoke and Salem.

The Virginian Railway Passenger Station, also known as the Virginian Station is a former rail station listed on the National Register of Historic Places in the South Jefferson neighborhood of the independent city of Roanoke, Virginia, U.S.A. Located at the intersection of Jefferson Street SE (VA 116) and Williamson Road, the Virginian Station served as a passenger station for the Virginian Railway between 1910 and 1956. The station was the only station constructed with brick along the entire length of the Virginian's 608 miles (978 km) network. It was severely damaged by fire on January 29, 2001.

Old Southwest is a neighborhood of the independent city of Roanoke, Virginia, United States. Located geographically near the center of the city, Old Southwest was annexed from Roanoke County in 1890 and developed as one of Roanoke's more affluent residential areas. Today the majority of the neighborhood falls within the Southwest Historic District listed on both the Virginia Landmarks Register and the National Register of Historic Places.

Mill Mountain Theatre (MMT) is a professional equity theatre located in Roanoke, Virginia. Originally opening as Mill Mountain Playhouse as a “not-for-profit, non-Equity resident stock theatre”, the location burned down in 1976, leading to a re-opening and renaming at the Center in the Square in 1983. The theater is named after the nearby Mill Mountain, which is a popular theme for the naming of Roanoke landmarks and organizations, including the Mill Mountain Star, Mill Mountain Zoo, and Mill Mountain Coffee and Tea.Mill Mountain Theatre also has a longstanding relationship with Hollins University and the Hollins Theatre Institute.

Roanoke City Market Historic District, also known as City Market District, is a national historic district located in the Downtown Roanoke area of Roanoke, Virginia. The district's history dates to 1882, when the Norfok and Western Railway (N&W) began the process of locating its headquarters to the small town of Big Lick. That decision precipitated a name change for the town to Roanoke, as well as a migration of the town's business district southeast towards the new railroad depot and hotel being built by the N&W. A town square along Campbell Avenue began seeing use as a makeshift open-air market, and in 1884 the new City of Roanoke's original charter provided for the construction of a municipal market. Completed in 1886, the original market building occupied the northwestern portion of the square; when that building was destroyed by fire it was replaced in 1922 with the current building and its centered arrangement.It was listed on the National Register of Historic Places in 1983, with an area roughly bounded by Williamson Rd., Norfolk Ave., S. Jefferson St., and Church Ave. The district area was increased to include 302 Campbell Ave., SE, and 9 Church Ave, SE, in 2002. The district encompasses 51 contributing buildings and 1 contributing object. The focal point of the area's grid-plan is the City Market Building (1922) set in the middle of the central Market Square. Other notable buildings include the Hartsook Building (1897), Lampros Building (1909), the McGuire Building (1914), and the Goria Brothers Grocery Building (1924). Located in the district is the separately listed Fire Station No. 1.

The Roanoke River and Railroad Historic District is a predominantly industrial area on the north side of the Roanoke River in Roanoke, Virginia. The area is bounded by South Jefferson Street on the west and the Roanoke River to the east, and extends north as far as Albemarle Avenue. The district's resources are defined primarily by their relationship to the railroad tracks that bisect this area. The area was developed in the late 19th and early 20th centuries with the completion of the Roanoke & Southern line in 1892 and the Virginian Railway line in 1909, and consists primarily of functional industrial buildings that were built between about 1900 and 1930, an example of which is the Virginia Can Company (built in 1912, listed on the National Register of Historic Places in 2006). Notable exceptions are the Virginian Railway Passenger Station, a Spanish Revival passenger station built 1909-10 and listed on the National Register of Historic Places since 2003, and the Walnut Street and Jefferson Street bridges, completed in 1927 and 1928, respectively. Both bridges were constructed in the Art Deco style and designed with "Egyptian Babylonian" style decorations.Many of the former industrial buildings located in the district have been demolished as part of a city-led redevelopment plan. Sixteen remaining structures contribute to the historic district, which was listed on the National Register of Historic Places in 2013.