United States District Court for the Western District of Virginia

A statue of Henrietta Lacks was installed in Roanoke, Virginia, in 2024. The artwork was designed by Bryce Cobbs and completed by Lawrence Bechtel.

The Robert E. Lee Memorial was a monument commemorating Robert E. Lee, formerly installed in Roanoke, Virginia's Lee Plaza. The stone memorial was approximately 10 feet (3.0 m) tall, and was erected by the United Daughters of the Confederacy in the fall of 1960, just as the first two black students were enrolled in the all-white school system. The monument's erection coincided with the run up to the centennial of the Civil War in 1961. In June 2020, the Roanoke City Council voted to start the legal process to remove the monument and rename Lee Plaza after the July 1, 2020 date when a new state law did away with the prohibition against removing monuments to the Confederate States of America. On just before midnight July 22, 2020, the monument was found to be torn down and broken into two pieces. A 70-year-old man named William Foreman, who was caught vandalizing the monument the night before it was torn down, was arrested on July 24, 2020, and eventually pleaded guilty to a misdemeanor. Lee Plaza was renamed Lacks Plaza after Henrietta Lacks, an African-American woman whose cells are the source of the first immortalized human cell line, and who was born in Roanoke. A statue of Lacks was unveiled in the plaza on October 4, 2023. Evergreen Burial Park submitted a proposal to the Roanoke City Council, to relocate the monument to the burial park that was accepted by the council. The proposed location for the re-erecting the statue is at the east end of the park adjacent to the flagpole dedicated to the Space Shuttle Challenger Disaster.

The Roanoke Downtown Historic District is a national historic district located in the Downtown Roanoke area of Roanoke, Virginia. It encompasses 122 contributing buildings. It includes a variety of commercial, institutional, social, and governmental buildings and structures from the late 19th century to the mid-20th century. Notable buildings include the Roanoke City Public Library, the YMCA Central Branch Building, First Christian Church (1925), the Central Church of the Brethren (1924), Tomnes Cawley Funeral Home (1928), Thomas B. Mason Building (1961), Peerless Candy Co. (c. 1916), City Hall / Municipal Building (1915), Roanoke Times Building (1892), Anchor Building / Shenandoah Building (1910), Greene Memorial Methodist Church (1890), and United States Post Office and Courthouse (1930). Located in the district are the separately listed Patrick Henry Hotel, Boxley Building, Campbell Avenue Complex Historic District, Colonial National Bank, and First National Bank.It was listed on the National Register of Historic Places in 2002.

Roanoke High School was the first public high school in Roanoke, Virginia. Located at 211-217 Church Ave. S.W., it opened on February 6, 1899. It closed in 1924, replaced by Jefferson High School, and became a school administration building. It was demolished in February 1968 and is now the site of the Noel C. Taylor Municipal Building.

Roanoke ( ROH-ə-nohk) is an independent city in the U.S. state of Virginia. It is located in Southwest Virginia along the Roanoke River, in the Blue Ridge range of the greater Appalachian Mountains. Roanoke is approximately 50 miles (80 km) north of the Virginia–North Carolina border and 250 miles (400 km) southwest of Washington, D.C., along Interstate 81. At the 2020 census, Roanoke's population was 100,011, making it the largest city in Virginia west of the state capital Richmond. It is the primary population center of the Roanoke metropolitan area, which had a population of 315,251 in 2020. The Roanoke Valley was originally home to members of the Siouan-speaking Tutelo tribe. However, in the 17th and early-to-mid 18th centuries, Scotch-Irish and later German American farmers gradually drove those Native Americans out of the area as the American frontier pressed westward. In 1882, the Norfolk and Western Railway (N&W) chose the small town of Big Lick as the site of its corporate headquarters and railroad shops. Within two years, the town had become the City of Roanoke. With a 2,300% population growth rate in the decade from 1880 to 1890, the young city experienced the advantages and disadvantages of its boomtown status. During the 20th century, Roanoke's boundaries expanded through multiple annexations from the surrounding Roanoke County, and it became Southwest Virginia's economic and cultural hub. The 1982 decision by N&W to relocate their headquarters out of the city, combined with other manufacturing closures, led Roanoke to pivot to a primarily service economy. In the 21st century, a robust healthcare industry and the development and increased marketing of its outdoor amenities have helped reverse prior declining population trends. Roanoke is known for the Roanoke Star, an 88.5-foot-tall (27.0 m) illuminated star that sits atop a mountain within the city's limits and is the origin of its nickname, "The Star City of the South". Other points of interest include the Hotel Roanoke, a 330-room Tudor Revival structure built by N&W in 1882, the Taubman Museum of Art, designed by architect Randall Stout, and the city's farmer's market, the oldest continuously operating open-air market in the state. The Roanoke Valley features 26 miles of greenways with bicycle and pedestrian trails, and the city's location in the Blue Ridge Mountains provides access to numerous outdoor recreation opportunities.

Carilion Roanoke Memorial Hospital (CRMH) is a private teaching hospital in Roanoke, Virginia, USA. With 703 beds, Carilion Roanoke Memorial Hospital is one of the largest hospitals in the state. It is part of Carilion Clinic.The region's only level I trauma center, the hospital operates three medical helicopters (LifeGuard 10, 11, and 12) to provide air ambulance transport, including one in Moneta, one in Christiansburg, and one in Lexington.

Campbell Avenue Complex, also known as the Trinkle Buildings, is a historic commercial block and national historic district located at Roanoke, Virginia. It encompasses five contributing buildings constructed between 1892 and 1909. The contiguous three-story buildings are constructed of brick over stone foundations. The buildings have a horizontal arrangement of windows above first-floor storefronts and include buildings representative of the Beaux Arts and Tudor Revival styles.It was listed on the National Register of Historic Places in 1991.

St. John's Episcopal Church is a historic Episcopal church in Roanoke, Virginia, United States. It was built in 1891–1892, and is a Gothic style limestone church designed by Charles M. Burns of Philadelphia. The building is a nave-plan, clerestory-style church that includes a corner bell tower and a narthex and chapel in the rear. A Tudor Revival style parish house was constructed in 1923. The church's congregation is one of the city's oldest, and has included many prominent local, state, and national leaders. The church was listed on the National Register of Historic Places in 1991.

The Patrick Henry Hotel is a Colonial Revival former hotel listed on both the National Register of Historic Places and the Virginia Landmarks Register in Downtown Roanoke, Virginia, United States. Located at 617 South Jefferson Street at the southern end of Downtown, the Patrick Henry was designed by William Lee Stoddart and opened in 1925. The building now serves as apartments, office space, and a restaurant in the former lobby rebranded simply The Patrick Henry. It is located in the Roanoke Downtown Historic District.

USS Roanoke (CL-145) was the second ship of the Worcester-class light cruisers completed for the U.S. Navy shortly after the end of World War II. Commissioned in 1949, she served in the Atlantic, Mediterranean and Pacific before being decommissioned in 1958. She was sold for scrap in 1972.

The Boxley Building is a historic commercial building located in Roanoke, Virginia. It was built in 1922, during a wave of post-World War I construction in the city. The building is eight stories, and follows a pattern set by other skyscrapers of the time in consisting of three sections similar to a classical column. The bottom section, or pedestal, is one story fronted with granite; the middle section, or shaft, consists of the next six stories built with beige enameled brick; the top section, or capital, is the eighth story fronted with richly decorated terra cotta panels topped with a finely detailed copper cornice.The building was commissioned by William Wise Boxley, a local builder and developer who was Roanoke's mayor at the time of construction. Boxley was an influential figure in the city, having played a significant role in the founding of the Shenandoah Life Insurance Company and Colonial American Bank as well as sitting on the boards of both Roanoke College and Virginia Military Institute. Boxley was elected to the Roanoke City Council in 1918, and the following year was appointed the city's first mayor under its new council-manager form of government.: 552  The building's architect was Edward G. Frye, whose firm had previously erected the Roanoke Times building, the city's municipal building, and would complete Roanoke's new market building in the same year as the Boxley.: 500, 504, 586 Boxley's building materials company was one of the original tenants of the building, and remained headquartered there until vacating in 2005. The building was empty from the late-2000s until being purchased by a local developer in 2016. The building's offices were converted into residential space, with the bottom four floors used as dormitory housing for international students of two Roanoke-area parochial schools, and the top four floors converted into luxury apartments.The building was listed on the National Register of Historic Places in 1984, and it is a contributing structure to the Roanoke Downtown Historic District.

Beth Israel Synagogue (Hebrew: בית ישראל) is a Conservative synagogue located at 920 Franklin Road in Roanoke, Virginia, in the United States. The synagogue was founded in 1900, and as of 2009, it had a membership of approximately 160 families and individuals.The 1925 building, designed by Frye and Stone, combines Classical Revival features in an unusual and rather severe design. A two-story Ionic portico, with an entablature, is engaged with and centered on the stepped gabled and parapeted façade. Doors and windows occupy each of the bays between the columns. A small Star of David occupies the gable.In 2007 the synagogue completed an expansion and renovation of its building, carefully planned so that the original facade, part of Roanoke's Old Southwest historic district, was unaltered.Rabbi Fabian Werbin commenced in 2008.