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The London Astoria was a music venue at 157 Charing Cross Road, in London, England. Originally a warehouse during the 1920s, the building became a cinema and ballroom. It was converted for use as a theatre in the 1970s. After further development, the building re-opened in the mid-1980s, as a night club and live music venue for well-known musical acts. There are half a dozen clubs and smaller music venues in the adjacent buildings. In 2009 the venue closed, and was demolished as part of the development plans of the Crossrail project. The venue is still seen today as having been an iconic music establishment, as it helped to launch the careers of many British rock bands and also played a part in the UK success of many international acts.

The Astoria 2, subsequently known as the LA2 then the Mean Fiddler, was a nightclub at 165 Charing Cross Road in London, England.

Nag Nag Nag was an influential London club night at Simon Hobart's Ghetto nightclub. Founded by DJ, promoter and musician Jonny Slut in 2002, it ran for six years. The night is commonly associated with the ambisexual post-electroclash scene.

Oxford Music Hall was a music hall located in Westminster, London at the corner of Oxford Street and Tottenham Court Road. It was established on the site of a former public house, the Boar and Castle, by Charles Morton, in 1861. In 1917 the music hall was converted into a legitimate theatre, and in 1921 it was renamed the New Oxford Theatre. In May 1926 it closed and was demolished. The site was occupied by the first Virgin Megastore from 1979 and closed in 2009. In September 2012 a branch of the budget fashion retailer Primark opened on the site.

In the 1930s, London Transport Board installed an experimental refrigeration plant on the London Underground at Tottenham Court Road Underground station. The plant was operational between 1938 and 1949. The experimental plant was built because temperature measurements through the 1930s showed that the Underground was steadily getting warmer. Although the temperatures were not at unsafe levels (peaks of 82 °F / 27.8 °C occurred at a few stations in summertime), the LTB perceived that if the trend continued, cooling in summer would be required at some time in the future, and it would be sensible to develop suitable technology. The chiller used water as the working fluid. The evaporators consisted of indirect heat exchangers mounted in the platform tunnels which were fed water at just above 0 °C. The condenser was sited in the outflow air path of an existing tunnel cooling fan, which had been installed in a disused lift shaft at the station in 1933. The outgoing air going through the condenser was warmed by 2–3 °C, before being discharged to atmosphere. Two descriptions of the cooling capacity exist. The first (from 1939) gives the capacity as "about half a million British thermal units per hour." The second (1982) states that it was "equivalent to melting approximately 51 tonnes of ice per day." In SI units, these are 146 kW and 197 kW respectively. The experimental plant was not considered a success, mainly because the cooling it provided was at high cost. An extractor fan of the same cooling capacity ('cooling capacity' in the sense that a fan removes warm air in the tunnels and replaces it with cooler air from outside) used up one-eighth of the electricity of the experimental refrigeration plant. Not only that, such a fan was easier to maintain and cost less to install. In the austere post-war years, the electrical power drawn by the chiller could not be justified. It was used intermittently during the 1940s, and was decommissioned in 1949.

Tottenham Court Road is a London Underground and Elizabeth line station in St Giles in the West End of London. The station is served by the Central line, the Elizabeth line and the Charing Cross branch of the Northern line. The station is located at St Giles Circus, the junction of Tottenham Court Road, Oxford Street, New Oxford Street and Charing Cross Road and is in Travelcard Zone 1, with a second entrance at Dean Street.

St Giles Circus is a road junction in the St Giles district of the West End of London at the eastern end of Oxford Street, where it connects with New Oxford Street, Charing Cross Road and Tottenham Court Road, which it is more often referred to owing to the location of Tottenham Court Road Underground station directly under the junction. It is near to Soho, Covent Garden, Bloomsbury and Fitzrovia.

Outernet London is an entertainment, arts and culture district opened in 2022 in the West End of London. Named as "London's most visited tourist attraction" by The Times newspaper in 2023, it is the largest digital exhibition space in Europe with the "world's largest LED screen deployment". It is located adjacent to the eastern exit of the new Elizabeth line Tottenham Court Road Underground station, on the southern side of the public square, and it extends to Denmark Street - “Tin Pan Alley”, with St Giles High Street to the east and Charing Cross Road to the west.

St Giles's Pound was a cattle pound at St Giles Circus in central London in the 17th and 18th centuries, at the intersection of the roads from Hampstead and from Oxford. It became a point from which distances to London were measured. The pound was located in the parish of St Giles-in-the-Fields, close to the boundary with St Anne, Westminster. It was originally located in the middle of St Giles High Street, but was moved in 1656 to the corner of Tottenham Court Road, Oxford Street and St Giles High Street. It was removed in 1765. It is mentioned in the old song Jack Chance: "On Newgate steps Jack Chance was found, and bred up near St Giles's Pound."

The Flying Horse (previously The Tottenham) is a Grade II* listed public house at 6 Oxford Street, Fitzrovia, Westminster. It was built in the 19th century, and is the last remaining pub on Oxford Street. The pub is on the Campaign for Real Ale's National Inventory of Historic Pub Interiors.Known for a time as The Tottenham, it was renamed the Flying Horse in 2015, the pub's name prior to its redevelopment in 1894.

The Dominion Theatre is a West End theatre and former cinema on Tottenham Court Road, close to St Giles Circus and Centre Point, in the London Borough of Camden. Planned as primarily a musical theatre, it opened in 1929, but the following year became a cinema—it hosted the London premiere of Charlie Chaplin's City Lights with Chaplin in attendance—and in 1933 after liquidation of the controlling company was sold to Gaumont cinema chain, which later became part of the Rank Organisation. It was a major premiere cinema until the 1970s, when it began to host live concerts. In January 1981 it once more became primarily a live performance venue, and has since hosted many musicals, notably We Will Rock You which ran from 2002 to 2014. It also hosted the Royal Variety Performance seven times in the 1990s and early 2000s. It became a listed building in 1988 and after being saved from redevelopment, was sold to Apollo Leisure Group and subsequently to the Nederlander Organization. In the 21st century it has been extensively refurbished and renovated, including reclaiming spaces that had been turned into offices. On Sundays Hillsong Church London holds services in the theatre.

Centre Point is a building in Central London, comprising a 34-storey tower; a 9-storey block to the east including shops, offices, retail units and maisonettes; and a linking block between the two at first-floor level. It occupies 101–103 New Oxford Street and 5–24 St Giles High Street, WC1, with a frontage also to Charing Cross Road, close to St Giles Circus and almost directly above Tottenham Court Road tube station. The site was once occupied by a gallows, and the tower sits directly over the former route of St Giles High Street, which had to be re-routed for the construction. The building is 117 m (385 ft) high, has 34 floors and 27,180 m2 (292,563 sq ft) of floor space. Constructed from 1963 to 1966, it was one of the first skyscrapers in London, and as of 2009 was the city's joint 27th-tallest building. It stood empty from the time of its completion until 1975, and was briefly occupied by housing activists in 1974. Since 1995 it has been a Grade II listed building. In 2015 it was converted from office space to flats.