Building at 1644 Main Street

Efird's Department Store, also known as Lourie's Department Store, is a historic department store building located at Columbia, South Carolina. It was built about 1870, and is a rectangular brick building renovated and expanded in 1919. This included the addition of a third story and the installation of a new brick façade and store entrances. Between 1919 and 1958, it housed the Columbia branch of the Charlotte, North Carolina based Efird's Department Store chain. It currently houses a Mast General Store, which moved in on May 25, 2011. It was added to the National Register of Historic Places in 2012.

Lever Building is a historic commercial building located at Columbia, South Carolina. It was built in 1903, and is a three-story building faced with brown brick and terra cotta.It was added to the National Register of Historic Places in 1979.

The Bouchier Building is a historic commercial building located in Columbia, South Carolina. It was built in 1913–14, and is a three-story, terra cotta faced building with large areas of glass on the upper floors.It was added to the National Register of Historic Places as the Building at 1722–1724 Main Street in 1979.

The Greyhound Bus Depot is a former Greyhound Lines intercity bus station in Columbia, South Carolina. It is at 1200 Blanding Street in downtown Columbia. The depot was named to the National Register of Historic Places on December 28, 1989. After the bus terminal was closed, the building became a bank. Currently, it is a physician's office.

Sidney Park Colored Methodist Episcopal Church, also known as Sidney Park Christian Methodist Episcopal Church, is a historic Methodist Episcopal church located at Columbia, South Carolina. It was built in 1893, and is a brick Late Gothic Revival style church. It features the only set of octagonal towers in Columbia; each is topped by an octagonal steeple. The church also has lancet windows and pointed arches, wall buttresses, and a heavy timber truss system. The African-American congregation has a long history of involvement with civil rights activity and connection with the NAACP.It was added to the National Register of Historic Places in 1996.

The Columbia Museum of Art is an art museum in the American city of Columbia, South Carolina.

The Columbia City Hall, in Columbia, South Carolina, also known as Old United States Court House and Post Office, was built in 1870. It was listed on the National Register of Historic Places in 1973. It includes Renaissance architecture. It served historically as a courthouse and as a post office.It was designed by Alfred B. Mullett.

Ladson Presbyterian Church is a historic African American Presbyterian church located at 1720 Sumter Street in Columbia, South Carolina. The religious building was initially a chapel founded in 1838 and, rebuilt in 1896, and is a one-story-over-raised-basement, rectangular red brick building in the Renaissance Revival style. It has a front gable roof and features two brick entrance towers. The congregation was founded in 1838, as an offshoot congregation of the First Presbyterian Church.It was added to the National Register of Historic Places in 1998.

The J. Bratton Davis United States Bankruptcy Courthouse is a courthouse of the United States District Court for the District of South Carolina, located in Columbia, South Carolina. It was originally constructed in 1936, under the supervision of architect Harold Tatum. The courthouse is named for J. Bratton Davis, a bankruptcy judge first appointed in 1978 who later became Chief Judge of the U.S. Bankruptcy Court for the District of South Carolina, and he served in that capacity until 2000. The building is listed on the National Register of Historic Places, having been added to the list on March 2, 1979.

Canal Dime Savings Bank, also known as Eckerd's Drug Store, is a historic bank building located at Columbia, South Carolina. It was built between 1892 and 1895, and is a three-story, Romanesque Revival style brick building with a granite façade and red barrel tile roof. The building was purchased by Eckerd's Drug Store in 1936.It was added to the National Register of Historic Places in 1980.

Kress Building is a historic commercial building located at Columbia, South Carolina across the street from the Columbia Museum of Art. It was built in 1934 by S. H. Kress & Co., and is a two-story, Art Deco style building faced with white terra cotta and colored terra cotta ornamentation. It features rounded storefront windows and cornice that contains the word "Kress" and surmounted by a stepped parapet.As of 2016, the bottom floor is a Brazilian Steakhouse and the 2nd floor houses apartments. A penthouse is planned for the roof. It was added to the National Register of Historic Places in 1979.

The South Carolina Athletic Hall of Fame is an athletics hall of fame in the U.S. state of South Carolina. It is in the capital city of Columbia.