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The Bialystoker Synagogue at 7–11 Bialystoker Place, formerly Willett Street, between Grand and Broome Streets in the Lower East Side neighborhood of Manhattan, New York City is an Orthodox Jewish synagogue. The building was constructed in 1826 as the Willett Street Methodist Episcopal Church; the synagogue purchased the building in 1905. The synagogue was designated a New York City Landmark in 1966. It is one of only four early-19th century fieldstone religious buildings surviving from the late Federal period in Lower Manhattan, and is the oldest building used as a synagogue in New York City.

St. Augustine's Church is located at 290 Henry Street between Montgomery and Jackson Streets on the Lower East Side of Manhattan, New York City. In 2020, it reported 61 members, average attendance of 0, and $71,684 in plate and pledge income.

Paul Taylor Dance Company, is a modern dance company, formed by dancer and choreographer Paul Taylor (1930—2018). The modern dance company is based in New York, New York and was founded in 1954. Taylor originally performed in the companies of Merce Cunningham, Martha Graham, and George Balanchine, and founded his own in 1954. Dancers and choreographers who have emerged from his company include Twyla Tharp, Pina Bausch, David Parsons, Laura Dean, Bettie de Jong, Dan Wagoner, Carolyn Adams, Elizabeth Keen, Christopher Gillis, Senta Driver, Amy Marshall, Lila York, Patrick Corbin, and Takehiro Ueyama. Michael Novak was appointed artistic director designate by Taylor in the spring of 2018, and took over as artistic director in September 2018 after Taylor died.

Vladeck Houses is a public housing development built and maintained by the New York City Housing Authority on the Lower East Side of Manhattan.

Jewish Maternity Hospital was an obstetrics hospital located at 270-272 East Broadway, on the Lower East Side of Manhattan, New York City.

The Lower East Side, sometimes abbreviated as LES and sometimes referred to as Loisaida, is a historic neighborhood in the southeastern part of the New York City borough of Manhattan, roughly between the Bowery and the East River from Canal to Houston streets. Traditionally an immigrant, working-class neighborhood, it began rapid gentrification in the mid-2000s, prompting the National Trust for Historic Preservation to place the neighborhood on their list of America's Most Endangered Places.The Lower East Side is part of Manhattan Community District 3, and its primary ZIP Code is 10002. It is patrolled by the 7th Precinct of the New York City Police Department.

Cooperative Village is a community of housing cooperatives on the Lower East Side of Manhattan, New York City. The cooperatives are centered on Grand Street in an area south of the entrance ramp to the Williamsburg Bridge and west of the FDR Drive. Combined, the four cooperatives have 4,500 apartments in twelve buildings. The cooperatives were sponsored, organized and built by trade unions, the Amalgamated Clothing Workers of America and International Ladies' Garment Workers' Union, as well as the United Housing Foundation, a development organization set up by the unions in 1951.The cooperatives followed strict Rochdale Principles, with one vote per member, irrespective of the nominal value of his shares. Resale of shares was restricted; members moving out of the apartments had to sell their shares back to the cooperative at the buying price, minus a flip tax. After the original financing structures governing the apartments were phased out, beginning in 1986, the shareholders of each cooperative decided, in separate votes in 1997 and 2000, to abandon the limited equity rules and free the resale of shares, in some cases increasing the value of apartments fivefold. To keep the maintenance fees low for original tenants, many of them retirees, a high flip tax is charged, up to 25% of the gross sales price for "first sales" and up to 15% for "second sales". In a similar instance, the shareholders at the Penn South sister cooperative in the Chelsea section of Manhattan voted to continue operating under limited equity rules.

The Church of St. Mary is a Roman Catholic parish church in the Roman Catholic Archdiocese of New York, located at 438–440 Grand Street between Pitt and Attorney Streets in the Lower East Side neighborhood of Manhattan, New York City. Established in 1826 to serve Irish immigrants living in the neighborhood, it is the third oldest Catholic parish in New York. The church itself was built in 1832–33, and was then enlarged and had its facade replaced in 1871 by the prolific church architect Patrick Charles Keely. The original portion is the second oldest Roman Catholic structure in the city, after St. Patrick's Old Cathedral, which was built in 1815.

The Henry Street Settlement is a not-for-profit social service agency in the Lower East Side neighborhood of Manhattan, New York City that provides social services, arts programs and health care services to New Yorkers of all ages. It was founded under the name Nurses' Settlement in 1893 by progressive reformer and nurse Lillian Wald.

The Old Church of St. Rose of Lima is a former Roman Catholic parish church which was under the authority of the Roman Catholic Archdiocese of New York, located at 36 Cannon Street between Broome Street and Delancey Street in the Lower East Side of Manhattan, New York City. The rectory was located at 42 Cannon Street; the school was located at 290 Delancey Street. The 1871 church was described by The New York Times when it opened in 1871, as one of the finest churches in the city. The church was demolished around July 1901 and the site redeveloped in conjunction with the erection of the Williamsburg Bridge (1903) and public housing. A new church was begun shortly after property was purchased in July 1900 at Grand and Lewis Streets. The parish closed in the 1960s.

Nechtanc ("sandy point") was a Lenape settlement of the Canarsee located in what is now Two Bridges, Manhattan or the Lower East Side where the East River begins to turn north. In 1643, the settlement was the site of a massacre of Lenape people, mostly women and children, after the governor of New Netherland ordered the people killed as they slept. A simultaneous massacre occurred at Pavonia, just across the East River. The village is alternatively referred to in historical documents as Rechtauk.

Samuel Gompers Houses, also known as Gompers Houses, is a public housing development built and maintained by the New York City Housing Authority (NYCHA) on the Lower East Side of Manhattan on Pitt Street between Delancey and Stanton Streets. Gompers Houses is composed of two 20-story buildings with 474 apartments that house approximately 1,116 people. It is built on a 3.7 acres (15,000 m2) site bordered by Stanton Street to the north, Columbia Street to the east, Delancey Street to the south, and Pitt Street to the west.