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St. James Cathedral is a Roman Catholic cathedral located at 804 Ninth Avenue in the First Hill neighborhood of Seattle, Washington, United States. It is the mother church of the Archdiocese of Seattle and the seat of its archbishop, currently Paul D. Etienne. The cathedral is named for St. James the Greater, patron saint of the archdiocese, and is the third church in the territory presently known as the Archdiocese of Seattle to bear the name. The need for a cathedral in Seattle arose in 1903, when Edward O'Dea, bishop of what was then known as the Diocese of Nesqually (later spelled "Nisqually"), elected to move the Episcopal see from Vancouver, Washington, to Seattle. Construction began in 1905. The Cathedral was dedicated in 1907. In 1916, the cathedral underwent major renovations as a result of the collapse of its dome; other major renovations were completed in 1950 and 1994. The cathedral, rectory, and site were designated city landmarks in 1984.

Virginia Mason Hospital is a 336-bed teaching hospital in Seattle, Washington, part of the Virginia Mason Medical Center. The hospital is accredited by the Joint Commission and the Commission on Accreditation of Rehabilitation Facilities (CARF). Founded in 1920, the hospital operates several accredited residency programs that train newly graduated physicians.

Virginia Mason Medical Center, founded in 1920, is a private, non-profit organization located in Seattle, Washington, US.

Benaroya Research Institute (BRI) is a Seattle, Washington non-profit organization that conducts medical research on many diseases and immune disorders, including autoimmune disease. It is affiliated with Virginia Mason Health System, and is located on the campus of Virginia Mason Medical Center.Much of BRI's research aims to understand how immune cells function and why they malfunction to cause disease. BRI researchers study how immune cells contribute to rheumatoid arthritis, type 1 diabetes, multiple sclerosis and other diseases.BRI uses translational research and clinical trials to carry its findings from the lab to the clinic, to inform how physicians diagnose and treat disease.

First Hill is a neighborhood in Seattle, Washington, United States. It is named for the hill on which it is located, which in turn is so named for being the first hill encountered while traveling east from downtown Seattle toward Lake Washington. First Hill is bounded on the west by Interstate 5, beyond which is Downtown, on the north by E. Pike and E. Madison Streets, beyond which is Capitol Hill, and on the south by Yesler Way, beyond which is the International District. The City of Seattle provides conflicting information about its eastern limit, beyond which are Cherry Hill and the Central District. Some describe it as being bounded by Broadway and Boren Avenues, while others describe it as being bounded by 12th Avenue.First Hill has been home to Seattle University, a private Jesuit university, since 1891. Also located on the hill are Northwest School and Seattle Academy of Arts and Sciences—two highly regarded private schools—and the Catholic O'Dea High School and Frye Art Museum, as well as several churches that have become city landmarks: Trinity Parish Church, St. James Cathedral, and Seattle First Baptist Church.

Formerly known as Diocese of Nesqually, 1850-1907. The Roman Catholic Archdiocese of Seattle is an ecclesiastical territory or archdiocese of the Catholic Church (particularly the Roman Catholic or Latin Church) located in the U.S. state of Washington. Headquartered in Seattle, the archdiocese encompasses all counties in the state west of the Cascade Range. As of 3 September 2019, its archbishop is Paul D. Etienne. Its cathedral of the archiepiscopal see is St. James Cathedral in Seattle, and the former cathedral is the Proto-Cathedral of St. James the Greater, in Vancouver, Washington. The archdiocese succeeded to the Diocese of Nesqually headquartered in Vancouver, Washington, established in 1850 as a suffragan diocese of the Archdiocese of Oregon City. In 1903, the episcopal see was moved to Seattle, and the diocese's name was changed to Diocese of Seattle in 1907. The diocese was elevated to metropolitan archdiocesan status in 1951.

Town Hall Seattle, or Town Hall locally, is a cultural center and performance hall located on Seattle, Washington, USA's First Hill at 1119 8th Ave. Built as Fourth Church of Christ, Scientist, Seattle, a Church of Christ, Scientist church, from 1916 to 1922, it was sold by the church to its current owners in 1998 and reopened in 1999. In 2017, Town Hall announced they raised $20 million for a "top-to-bottom" renovation. In January 2019, they announced construction issues delayed their planned reopening. Town Hall officially completed construction and reopened its doors to the public on May 16, 2019.It was designated a Seattle Landmark in 2012 and was listed on the National Register of Historic Places as "Fourth Church of Christ, Scientist" in 2013.

O'Dea High School is a Catholic all boys high school founded in 1923 and is located in Seattle's First Hill neighborhood. The school is named after Edward John O'Dea who was bishop of Seattle when the school was built. O'Dea is a part of the Archdiocese of Seattle. Of its 507 students in four grades in 2020, 60% were Catholics, 58% were Caucasian, 13% were African American, and 19% were multi-racial. There are 36 instructors and the student-teacher ratio is 14 to 1. The tuition at O'Dea High School for the 2019-2020 school year was $16,576; the school provides over $1 million in financial aid every year.

The Women's University Club of Seattle is a social club for women located at 1105 Sixth Avenue in Seattle, Washington. The club's building was added to the National Register of Historic Places on July 10, 2009.

The Henry H. Dearborn House, also known as the Seattle Dearborn House is a single family residence in the First Hill neighborhood of Seattle, Washington, United States. It was designed in 1904 by architect Henry Dozier, and building was completed in 1907 for Seattle real estate developer Henry H. Dearborn. It is listed on the National Register of Historic Places and as a Seattle Landmark by the Seattle Landmarks Preservation Board. As of 2021, the building is used as the headquarters of Historic Seattle.The Dearborn house is two and a half stories in an American Foursquare style, with stucco exterior. The house has an enclosed veranda and an out building originally built as stables. In 1953 the house was converted to a medical office, and subsequently into office space.

Trinity Parish Church is a historic church located in the First Hill neighborhood of Seattle, Washington, that was added to the National Register of Historic Places in 1991. It is an Episcopal congregation in the Diocese of Olympia.

800 Fifth Avenue is a 166-meter (545 ft) skyscraper in Seattle, in the U.S. state of Washington. It was constructed from 1979 to 1981 and has 42 floors. It is the tenth-tallest building in Seattle and was designed by 3D/International. The building has been able to retain a minimum of 98% occupancy since it was opened. The building was previously known as Bank of America Fifth Avenue Plaza when its naming rights were held by the Bank of America. It was originally built for Seafirst Bank, which was acquired by the Bank of America prior to the tower's completion. In April 2014, its name was changed to 800 Fifth Avenue.