275 Madison Avenue

The Williams Club is in residence at the Penn Club of New York for alumni of Williams College. Until 2010, it had its own private clubhouse at 39th Street, which today operates as an unaffiliated boutique hotel.The Williams Club was founded in 1913 by Williams alumni in New York City as a place to socialize. The club was originally located at 291 Madison Avenue in a building donated by Mary Clark Thompson, wife of Williams alumnus Frederick Ferris Thompson. In 1921, it moved to 24 East 39th Street in Manhattan, which it then renovated in 1988. On June 1, 2010, however, the Williams Club ceased operating on its own and moved its membership program and related activities to the Princeton Club. After the permanent closure of the Princeton Club in fall 2021, the Williams Club moved to the Penn Club in March 2022. Today, members and their guests can use the Penn Club's facilities.

The Lefcourt Colonial Building is a 45-story office building located in Midtown Manhattan, in New York City, built by Abraham E. Lefcourt. The 538-foot-tall (164 m) neo-Gothic building, located at 295 Madison Avenue at East 41st Street, was completed in 1930.

The East Side of Manhattan refers to the side of Manhattan which abuts the East River and faces Brooklyn and Queens. Fifth Avenue, Central Park from 59th to 110th Streets, and Broadway below 8th Street separate it from the West Side. The major neighborhoods on the East Side include (from north to south) East Harlem, Yorkville, the Upper East Side, Turtle Bay, Murray Hill, Kips Bay, Gramercy, East Village, and the Lower East Side. The main north–south expressways servicing the East Side are the Franklin D. Roosevelt East River Drive and Harlem River Drive, which for the majority of their length are separated from the east shore of the island by the Manhattan Waterfront Greenway. The East Side is served by the IRT East Side Line subway and by many bus lines.

Library Hotel by Library Hotel Collection is a 60-room boutique hotel in New York City, located at 299 Madison Avenue (at 41st Street), near the New York Public Library Main Branch, Bryant Park, and Grand Central Terminal. The hotel was designed by architect Stephen B. Jacobs.Library Hotel by Library Hotel Collection boasts a unique organizing principle: each of its ten guest floors has a theme, designated after a major category of the Dewey Decimal Classification (the 5th floor, for example, is the 500s, the Sciences), with each room as a subcategory or genre, such as Mathematics (Room 500.001) or Botany (Room 500.004). (Dewey categories 000, 100, and 200 are placed on the 10th, 11th, and 12th floors, respectively.) Other room themes include Erotic Literature (Room 800.001), Poetry (Room 800.003), and Music (Room 700.005). All rooms have a small complement of 50–100 books and decorations that accompany the theme, with 6,000 books overall throughout the hotel.Because of this classification scheme, the hotel owners were sued in 2003 by the OCLC (owners of the Dewey Decimal Classification system). OCLC reached an agreement with the hotel enabling the hotel to continue using the Dewey system.The Library Hotel is owned and operated by Henry Kallan, whose Library Hotel Collection includes Manhattan's Casablanca Hotel, Hotel Giraffe and Hotel Elysee.

Wood Tobé–Coburn School was a private for-profit career college in New York City. It closed in 2017.

10 East 40th Street or the Mercantile Building is a skyscraper on 40th Street in Midtown Manhattan, New York City, in the middle of the block between Fifth and Madison avenues, extending back to 39th Street. Designed by Ludlow and Peabody and built by Jesse H. Jones, it was finished in 1929 and is an example of Renaissance Revival architecture. When it was built, it was the fourth-tallest tower in the world.It is 632 feet (193 m) high, with 48 floors, and contains 350,000 sq ft (33,000 m2) of office or mixed-use space.

Hills Learning is an Asian language school in New York City. It is located near Grand Central Terminal and has been recognized by several television stations, websites, and publications, such as PBS, TBS, CBS New York, and Chopsticks NY.

One Grand Central Place, originally the Lincoln Building, is a 53-story, 673 feet (205 m) tall neo-Gothic office building at 60 East 42nd Street in Midtown Manhattan, New York City. It is bounded by Madison Avenue to the west, East 41st Street to the south, and Park Avenue to the east. One Grand Central Place is near other skyscrapers such as the Chrysler Building, MetLife Building, and One Vanderbilt. It has direct in-building access to Grand Central Terminal to the north. As of 2021, it is the 91st-tallest building in the city, tied with the 277 Fifth Avenue, Barclay Tower, and One Court Square. The building is assigned its own ZIP Code, 10165; it was one of 41 buildings in Manhattan that had their own ZIP Codes as of 2019.

The Stavros Niarchos Foundation Library (SNFL), popularly known as the Mid-Manhattan Library, is a branch of the New York Public Library (NYPL) at the southeast corner of 40th Street and Fifth Avenue in the Midtown Manhattan neighborhood of New York City. It is diagonally across from the NYPL's Main Branch and Bryant Park to the northwest. The Stavros Niarchos Foundation Library has space for 400,000 volumes across a basement and seven above-ground stories. Its design includes 11,000 square feet (1,000 m2) of event space and 1,500 seats for library users. The Mid-Manhattan Library opened in 1970 to house the circulating collection formerly located in the NYPL's Main Branch. The branch moved to its current building, a former Arnold Constable & Company department store, in 1981. After a failed attempt to close the Mid-Manhattan Library in the 2010s, the NYPL announced a major renovation of the branch in 2014. Between 2017 and 2020, the branch was closed for renovations funded by the Stavros Niarchos Foundation, and the library was renamed after the foundation.

Scandinavia House – The Nordic Center in America is the American-Scandinavian Foundation's cultural center at 58 Park Avenue (between East 37th Street and East 38th Street), in Murray Hill, Manhattan, New York City. It is dedicated to preserving the history of the Scandinavian and Nordic countries in the United States through exhibits and programming. This cultural center hosts exhibitions of fine art, design as well as performing arts pieces from Nordic countries. The center also introduces the local population and guests with Scandinavian languages and customs by organizing courses.The Nordic Center was designed by architect James Stewart Polshek and opened to the public in 2000 with a visit from King Carl XVI Gustaf and Queen Silvia of Sweden and their eldest daughter, Princess Victoria, Princess Martha Louise of Norway, and Princess Benedikte of Denmark.

Reuben's Restaurant and Delicatessen was a restaurant and Jewish deli in Manhattan, New York City founded by Arnold Reuben.

Morgans Hotel was the world's first boutique hotel, located at 237 Madison Avenue in New York City. Founded by Studio 54 cofounder Ian Schrager as the first property in the Morgans Hotel Group, it opened in 1984.