Bust of John McDonogh

The New Orleans Public Library (NOPL) is the public library of the city of New Orleans, Louisiana, United States. Succeeding earlier libraries in the city, it opened in 1897. Three branches were added by 1908. Carnegie library branches were added in 1911 and 1915. By 2005 a dozen branches were open. The main library is listed on the National Register of Historic Places.

The Oil and Gas Building, or Oil & Gas Building, is a 14-story building, completed in 1959, at 1100 Tulane Avenue in the Central Business District of New Orleans, Louisiana, in the United States. Its original architects were August Perez / Edward B. Silverstein. It is now listed on the National Register of Historic Places. It was mostly vacant by 2003 and largely abandoned until purchased by a Maryland-based company in 2013 for a reported $7 million. A mixed-use residential property was originally envisioned, with loft apartments catering to employees of the nearby LSU Medical complex. Canopy by Hilton has now developed a hotel/restaurant property in the building which opened on March 28, 2022. Now known as Canopy By Hilton New Orleans Downtown.

The Tulane University School of Medicine is the medical school of Tulane University and is located in the Medical District of the New Orleans Central Business District in New Orleans, Louisiana, United States.

The Karnofsky Tailor Shop–House (also known as the Karnofsky Shop) was a historic, two-story building in the Central Business District of New Orleans, Louisiana, that played a significant role in the early promotion of jazz when the neighborhood was known as "Back of Town". It was destroyed by Hurricane Ida in 2021.

1010 Common (formerly the Bank of New Orleans Building), located at 1010 Common Street in the Central Business District of New Orleans, Louisiana, is a 31-story skyscraper. The building, designed by Skidmore, Owings & Merrill and completed in 1970, is an example of the international style typical of the time. It is located adjacent to the 14-story Latter Center Garage & Annex. It was listed on the National Register of Historic Places in 2016.

The Tulane Medical Center is a hospital located in New Orleans, Louisiana. The Tulane Medical Center has centers covering nearly all major specialties of medicine, and is the primary teaching hospital for the Tulane University School of Medicine. The hospital is jointly owned by Hospital Corporation of America (HCA) (82.5%) and Tulane University (17.5%). Tulane University and LCMC announced on October 10, 2022, that LCMC would purchase Tulane Medical Center (along with Lakeview Regional Medical Center, and Tulane Lakeside Hospital) from HCA for $150 Million.

New Orleans Exchange Centre, formerly known as Chevron Place, located at 935 Gravier Street in the Central Business District of New Orleans, Louisiana, is a 21-story, 238 feet (73 m)-tall skyscraper designed in the international style by Stanley Muller & Associates. Kingfish Development purchased the building from Chevron in 2010, using it primarily as leasable office space for more than a dozen businesses.

Orleans Tower (formerly Amoco Building), located at 1340 Poydras Street in the Central Business District of New Orleans, Louisiana, is a 20-story, 280 feet (85 m)-tall skyscraper designed in the international style by 3D/International. The international style grew in popularity during the sixties and seventies after the architect Mies Van Der Rohe designed the Seagram Building on Park Ave in New York City and Skidmore, Owings, and Merrill designed the Sears Tower in the heart of downtown Chicago. The building is primarily used for leaseable office space, with some retail space on the ground level. The design of the building can be best classified as international with its black aluminum and glass curtain wall. The building currently houses the offices of several city and state agencies, including the Orleans Parish District Attorney's Office. Orleans Tower is currently the 28th tallest building in New Orleans.

Tulane University School of Social Work is the social work school of Tulane University. The school is located on Tulane's Downtown New Orleans campus at 127 Elk Place. TSSW is fully accredited by the Council on Social Work Education.

Benson Tower (formerly Dominion Tower and the CNG Tower), located at 1450 Poydras Street in the Central Business District of New Orleans, Louisiana, is a 26-story, 406 feet (124 m)-tall skyscraper. The building was purchased by late New Orleans Saints owner Tom Benson on September 15, 2009 and renamed the Benson Tower. In 2012, Ochsner Health System moved executives and as many as 750 administrative employees to the top four floors as well as the 2nd and 3rd floor space with balconies overlooking Champions Square and the Caesars Superdome; second floor space is utilized for Benson's television station, Fox affiliate WVUE (Channel 8) for the station's morning newscast, sporting events and by lease for other parties. According to Corporate Realty, which leases the 487,760 sq ft (45,314 m2) building, as of August 2012, Benson Tower is more than 97.6% leased.

1250 Poydras Plaza (also known as the Eni Building and formerly the Mobil Building), is a high-rise international-style office building located at 1250 Poydras Street in the Central Business District of New Orleans, Louisiana. It has 24 stories, and stands at a height of 342 feet (104 m). In June 2010, the Unified Command moved its headquarters from the Dutch Royal Shell Conference Center in Robert, Louisiana, to the building to deal with the Deepwater Horizon oil spill.

The Energy Centre, located in the Central Business District of New Orleans, Louisiana, is a 39-story, 530 feet (162 m) -tall skyscraper designed by HKS, Inc. It is the fourth tallest building in both the city of New Orleans and the state of Louisiana. A four-story parking garage is adjacent to the tower, one block upriver. The garage is accessible from both Loyola Avenue and South Rampart Street. The building experienced minor damage during Hurricane Katrina in August 2005. Some windows near the top of the tower were blown out, however, these windows were mostly false windows that cover the climate control systems on the roof. The ceilings of the overhangs on the street level were badly damaged but have since been repaired.