Bust of John McDonogh

The Oil and Gas Building, or Oil & Gas Building, is a 14-story building, completed in 1959, at 1100 Tulane Avenue in the Central Business District of New Orleans, Louisiana, in the United States. Its original architects were August Perez / Edward B. Silverstein. It is now listed on the National Register of Historic Places. It was mostly vacant by 2003 and largely abandoned until purchased by a Maryland-based company in 2013 for a reported $7 million. A mixed-use residential property was originally envisioned, with loft apartments catering to employees of the nearby LSU Medical complex. Canopy by Hilton has now developed a hotel/restaurant property in the building which opened on March 28, 2022. Now known as Canopy By Hilton New Orleans Downtown.

The Karnofsky Tailor Shop–House (also known as the Karnofsky Shop) was a historic, two-story building in the Central Business District of New Orleans, Louisiana, that played a significant role in the early promotion of jazz when the neighborhood was known as "Back of Town". It was destroyed by Hurricane Ida in 2021.

1010 Common (formerly the Bank of New Orleans Building), located at 1010 Common Street in the Central Business District of New Orleans, Louisiana, is a 31-story skyscraper. The building, designed by Skidmore, Owings & Merrill and completed in 1970, is an example of the international style typical of the time. It is located adjacent to the 14-story Latter Center Garage & Annex. It was listed on the National Register of Historic Places in 2016.

The Tulane Medical Center is a hospital located in New Orleans, Louisiana. The Tulane Medical Center has centers covering nearly all major specialties of medicine, and is the primary teaching hospital for the Tulane University School of Medicine. The hospital is jointly owned by Hospital Corporation of America (HCA) (82.5%) and Tulane University (17.5%). Tulane University and LCMC announced on October 10, 2022, that LCMC would purchase Tulane Medical Center (along with Lakeview Regional Medical Center, and Tulane Lakeside Hospital) from HCA for $150 Million.

New Orleans Exchange Centre, formerly known as Chevron Place, located at 935 Gravier Street in the Central Business District of New Orleans, Louisiana, is a 21-story, 238 feet (73 m)-tall skyscraper designed in the international style by Stanley Muller & Associates. Kingfish Development purchased the building from Chevron in 2010, using it primarily as leasable office space for more than a dozen businesses.

Orleans Tower (formerly Amoco Building), located at 1340 Poydras Street in the Central Business District of New Orleans, Louisiana, is a 20-story, 280 feet (85 m)-tall skyscraper designed in the international style by 3D/International. The international style grew in popularity during the sixties and seventies after the architect Mies Van Der Rohe designed the Seagram Building on Park Ave in New York City and Skidmore, Owings, and Merrill designed the Sears Tower in the heart of downtown Chicago. The building is primarily used for leaseable office space, with some retail space on the ground level. The design of the building can be best classified as international with its black aluminum and glass curtain wall. The building currently houses the offices of several city and state agencies, including the Orleans Parish District Attorney's Office. Orleans Tower is currently the 28th tallest building in New Orleans.

Benson Tower (formerly Dominion Tower and the CNG Tower), located at 1450 Poydras Street in the Central Business District of New Orleans, Louisiana, is a 26-story, 406 feet (124 m)-tall skyscraper. The building was purchased by late New Orleans Saints owner Tom Benson on September 15, 2009 and renamed the Benson Tower. In 2012, Ochsner Health System moved executives and as many as 750 administrative employees to the top four floors as well as the 2nd and 3rd floor space with balconies overlooking Champions Square and the Caesars Superdome; second floor space is utilized for Benson's television station, Fox affiliate WVUE (Channel 8) for the station's morning newscast, sporting events and by lease for other parties. According to Corporate Realty, which leases the 487,760 sq ft (45,314 m2) building, as of August 2012, Benson Tower is more than 97.6% leased.

1250 Poydras Plaza (also known as the Eni Building and formerly the Mobil Building), is a high-rise international-style office building located at 1250 Poydras Street in the Central Business District of New Orleans, Louisiana. It has 24 stories, and stands at a height of 342 feet (104 m). In June 2010, the Unified Command moved its headquarters from the Dutch Royal Shell Conference Center in Robert, Louisiana, to the building to deal with the Deepwater Horizon oil spill.

The Energy Centre, located in the Central Business District of New Orleans, Louisiana, is a 39-story, 530 feet (162 m) -tall skyscraper designed by HKS, Inc. It is the fourth tallest building in both the city of New Orleans and the state of Louisiana. A four-story parking garage is adjacent to the tower, one block upriver. The garage is accessible from both Loyola Avenue and South Rampart Street. The building experienced minor damage during Hurricane Katrina in August 2005. Some windows near the top of the tower were blown out, however, these windows were mostly false windows that cover the climate control systems on the roof. The ceilings of the overhangs on the street level were badly damaged but have since been repaired.

Charity Hospital was one of two teaching hospitals which were part of the Medical Center of Louisiana at New Orleans (MCLNO), the other being University Hospital. Three weeks after the events of Hurricane Katrina, then-Governor Kathleen Blanco said that Charity Hospital would not reopen as a functioning hospital. The Louisiana State University System, which owns the building, stated that it had no plans to reopen the hospital in its original location. It chose to incorporate Charity Hospital into the city's new medical center in the lower Mid-City neighborhood. The new hospital completed in August 2015 was named University Medical Center New Orleans.

NOPSI New Orleans, or the NOPSI Hotel, is a hotel in the historic NOPSI building in downtown New Orleans, Louisiana. The building is the former headquarters of New Orleans' main utilities company, the New Orleans Public Service Incorporated, which was set up in 1922 to consolidate numerous separate public utilities firms. Its nine-story building was designed by architects Favrot and Livaudais, and was constructed in 1927. The building "displayed some of the finest architectural finishes throughout the whole city. Perhaps the greatest feature was the ornate lobby that resembled the ground floor of a bank."The NOPSI entity relocated away in 1983, and the building was then vacant for many years. In 1991 it was included as a contributing building in the listing of the New Orleans Lower Central Business District onto the National Register of Historic Places.Eventually it was converted into the current 217-room hotel, which opened in 2017.It has been listed by the National Trust for Historic Preservation as a member of the Historic Hotels of America program since 2016.The hotel is noted as one of few boutique hotels owned by black women. Sheila Johnson, NOPSI's owner who has had other business successes, is credited with reopening the hotel after it had been unused since the 1980s. It is deemed to be a luxury hotel, and its grand lobby has been asserted to be stunning.New Orleans City Business pointed out in 2021 that the renovation was an adaptive reuse project, one of few recent at that time, as suitable properties in New Orleans central business district were simply not available.It is now a top New Orleans hotel.The building is located essentially on the northwest corner of the intersection of Union and Baronne Streets. A small rectangular plaza at the very corner, however, makes a notched footprint into the building, so the building's footprint forms a very heavy L-shape around that rectangle. The plaza is walled off from the sidewalks and is part of the NOPSI property. It is just three blocks (0.2 miles (0.32 km) northeast along Baronne to New Orleans' major Canal Street thoroughfare, and then just one block southeast to the beginning of Bourbon Street, noted as a major entrance into the French Quarter. The building's roof sports an outdoor pool.

The First Bank and Trust Tower (also known as the First Bank Tower and previously known as the LL&E Tower and 909 Poydras Tower), located at 909 Poydras Street in the Central Business District of New Orleans, Louisiana, is a 36-story, 481 feet (147 m)-tall skyscraper designed in the post-modern style by Welton Becket & Associates and developed by Joseph C. Canizaro. It is the fifth tallest building in both the city of New Orleans and the state of Louisiana. Floors 2-8 are parking levels, and 10-36 hold office space. Hertz Investment Group is the current owner, having acquired the building in 2005. Beau Box Commercial Real Estate handles the leasing for this building. The current name comes from the New Orleans area bank First Bank and Trust, the previous name comes from the Louisiana Land & Exploration Company. The exterior of the building is clad in granite and bronze tinted glass. The building is illuminated by spotlights at night, making it one of the most visible buildings in New Orleans' night time skyline. The 7 levels of parking are accessed from O'Keefe Avenue. In front of the main entrance on Poydras Street are a pair of bronze sculptures by Enrique Alférez depicting David and a lute player. The building suffered some damage during Hurricane Katrina in August 2005, including blown out windows and roof damage. The building reopened to tenants in late 2005.