Albright United Methodist Church

Roslyn Place is a small wooden-paved cul-de-sac located in the Shadyside neighborhood of Pittsburgh, Pennsylvania. The street was built in 1914 in the Nicolson Pavement style and is home to the historic Roslyn Place district.

Roslyn Place is a collection of houses located at 506-523 & 525 Roslyn Place in the Shadyside neighborhood of Pittsburgh, Pennsylvania. Built between 1914 and 1917 in the Colonial Revival and Georgian Revival architectural styles, the houses currently serve residential functions.

Ellsworth Avenue is located in the Shadyside neighborhood of Pittsburgh, Pennsylvania. It is mostly a commercial street that has locally owned businesses, galleries, restaurants, and bars. It runs southwest-northeast, parallel to Walnut Street, another commercial street, and is bounded by Shady Avenue to the east and South Neville Street to the west. Ellsworth Avenue is one of Shadyside's three business districts, along with South Highland Avenue and Walnut Street.Several Pittsburgh Historic Landmarks line Ellsworth Avenue. At the corner of Neville and Ellsworth is the Church of the Ascension, an episcopalian church that was named a landmark in 1971. Colonial Place is a mansion designed by George S. Orth that became a landmark in 1898. Roslyn Place (a wood-paved street) and Ellsworth Terrace are also landmarks located here.

UPMC Shadyside is a nationally ranked, 520-bed non-profit, tertiary, teaching hospital located in the Shadyside neighborhood of Pittsburgh, Pennsylvania. UPMC Shadyside is a part of the University of Pittsburgh Medical Center (UPMC), and grouped in with the flagship UPMC Presbyterian. The hospital is near UPMC's flagship campus which houses Presbyterian and Montefiore. As the hospital is a teaching hospital, it is affiliated with University of Pittsburgh School of Medicine. The hospital has an emergency room to handle emergencies, with a rooftop helipad to transport critical patients to and from the hospital. UPMC Shadyside houses the flagship campus of the UPMC Hillman Cancer Center, a nationally ranked cancer hospital.Founded in as the Homeopathic Medical and Surgical Hospital and Dispensary, it changed its name to that of the neighborhood of Shadyside on May 12, 1938. Shadyside agreed to be bought by UPMC on June 5, 1996.

Negley is a station on the East Busway, located in Shadyside and near the East Liberty and Friendship neighborhoods of Pittsburgh.

The Bindley Hardware Company Building in the Shadyside neighborhood of Pittsburgh, Pennsylvania was built in 1903 alongside of the Pennsylvania Railroad main line, next to the Shadyside Station. The building was constructed for John Bindley by his brother Albion. John had been the president of the Pittsburgh Chamber of Commerce and of the National Hardware Association. He tried to organize the industry into a "National Combine" or trust, but this attempt failed due to opposition from the government. Instead, he organized a dominant regional hardware wholesaler in Pittsburgh, a major center of hardware manufacture, with this building serving as its main warehouse.The building was listed on the National Register of Historic Places in 1985.

The Liberty School No. 4, Friendship Building is a school building built in 1899 in the Friendship neighborhood of Pittsburgh, Pennsylvania. It now houses Pittsburgh Montessori School PreK-5, a public Montessori Magnet School that is part of the Pittsburgh Public School District. It was listed on the National Register of Historic Places in 1986.

The UPMC Hillman Cancer Center (Hillman), previously titled the University of Pittsburgh Cancer Institute (UPCI), is a National Cancer Institute (NCI)-designated Comprehensive Cancer Center located in the Hillman Cancer Center in the Shadyside neighborhood of Pittsburgh, Pennsylvania, United States, adjacent to UPMC Shadyside. The only NCI-designated cancer center in Western Pennsylvania, Hillman is composed of collaborative academic and research efforts between the University of Pittsburgh, the University of Pittsburgh Medical Center (UPMC), and Carnegie Mellon University. Hillman provides clinical cancer care to some 74,000 patients treated at its facilities at both the Hillman Cancer Center location in the Shadyside neighborhood of Pittsburgh and at UPMC-affiliated sites throughout Pennsylvania, New York, Ohio, and overseas locations. Founded in 1984, Hillman became the youngest cancer center in history to achieve NCI-designation. As of 2007, Hillman had received nearly $200 million in funding from the National Cancer Institute, which ranks it as one of the top ten cancer research institutes.

Whitehill-Gleason Motors at 5815 Baum Boulevard in the East Liberty neighborhood of Pittsburgh, Pennsylvania, was built in the 1920s on the site of the first drive-in filling station (1913).It was added to the National Register of Historic Places on July 22, 1999, and was granted a Pennsylvania Historical Marker on July 11, 2000.

The Children's Home of Pittsburgh, established in 1893, is an independent non-profit organization in Pittsburgh, Pennsylvania. The organization's mission is "to promote the health and well-being of infants and children through services which establish and strengthen the family," including adoption, day care and pediatric health care. In March 2007, the Children's Home moved to Penn Avenue in the Friendship neighborhood of Pittsburgh. It added "Lemieux Family Center" to its name in recognition of ongoing support from the Mario Lemieux Foundation.

Winchester Thurston School is an independent, coeducational preparatory school located in the Shadyside neighborhood of Pittsburgh, Pennsylvania. Established in 1887, Winchester Thurston offers PK–12 education in Lower, Middle, and Upper School. The school is a member of the Pittsburgh Consortium of Independent Schools.

Addy-Spencer House located at 919–20 St. James Street in the Shadyside neighborhood of Pittsburgh, Pennsylvania, was built in 1869. It was added to the List of Pittsburgh History and Landmarks Foundation Historic Landmarks in 2000.