UPMC Shadyside

The Bindley Hardware Company Building in the Shadyside neighborhood of Pittsburgh, Pennsylvania was built in 1903 alongside of the Pennsylvania Railroad main line, next to the Shadyside Station. The building was constructed for John Bindley by his brother Albion. John had been the president of the Pittsburgh Chamber of Commerce and of the National Hardware Association. He tried to organize the industry into a "National Combine" or trust, but this attempt failed due to opposition from the government. Instead, he organized a dominant regional hardware wholesaler in Pittsburgh, a major center of hardware manufacture, with this building serving as its main warehouse.The building was listed on the National Register of Historic Places in 1985.

The UPMC Hillman Cancer Center (Hillman), previously titled the University of Pittsburgh Cancer Institute (UPCI), is a National Cancer Institute (NCI)-designated Comprehensive Cancer Center located in the Hillman Cancer Center in the Shadyside neighborhood of Pittsburgh, Pennsylvania, United States, adjacent to UPMC Shadyside. The only NCI-designated cancer center in Western Pennsylvania, Hillman is composed of collaborative academic and research efforts between the University of Pittsburgh, the University of Pittsburgh Medical Center (UPMC), and Carnegie Mellon University. Hillman provides clinical cancer care to some 74,000 patients treated at its facilities at both the Hillman Cancer Center location in the Shadyside neighborhood of Pittsburgh and at UPMC-affiliated sites throughout Pennsylvania, New York, Ohio, and overseas locations. Founded in 1984, Hillman became the youngest cancer center in history to achieve NCI-designation. As of 2007, Hillman had received nearly $200 million in funding from the National Cancer Institute, which ranks it as one of the top ten cancer research institutes.

The Albright United Methodist Church is located at 486 S. Graham Street at the nexus of the Bloomfield, Shadyside, and Friendship neighborhoods of Pittsburgh, Pennsylvania. The church was designed by architect Chancey W. Hodgdon in an Eclectic, Richardson Romanesque style with prominent elements of Gothic Revival, and was built in 1905-1906.

Winchester Thurston School is an independent, coeducational preparatory school located in the Shadyside neighborhood of Pittsburgh, Pennsylvania. Established in 1887, Winchester Thurston offers PK–12 education in Lower, Middle, and Upper School. The school is a member of the Pittsburgh Consortium of Independent Schools.

Roslyn Place is a small wooden-paved cul-de-sac located in the Shadyside neighborhood of Pittsburgh, Pennsylvania. The street was built in 1914 in the Nicolson Pavement style and is home to the historic Roslyn Place district.

Roslyn Place is a collection of houses located at 506-523 & 525 Roslyn Place in the Shadyside neighborhood of Pittsburgh, Pennsylvania. Built between 1914 and 1917 in the Colonial Revival and Georgian Revival architectural styles, the houses currently serve residential functions.

The Ford Motor Company Assembly Plant is a historic former automobile assembly plant in the Bloomfield neighborhood of Pittsburgh, Pennsylvania. Located along a stretch of Baum Boulevard nicknamed "Automobile Row" due to its high concentration of auto-related businesses, the plant was built in 1915 by Ford Motor Company to assemble Ford Model T cars using the company's pioneering mass production processes. It was designed by Ford's corporate architect John H. Graham, Sr. and constructed from reinforced concrete. The plant consists of an eight-story main building which contained the assembly areas and a vehicle showroom, and a six-story crane shed which was used to hoist parts unloaded from the adjacent Pennsylvania Railroad tracks to the appropriate level for assembly. Due to the steeply sloping site, the building has only five stories above grade along the street elevations.The plant stopped producing cars in 1932, but remained in use for vehicle and parts sales until 1953. The building then went through a variety of light industrial uses before being purchased by the University of Pittsburgh Medical Center (UPMC) in 2006. It was subsequently purchased by the University of Pittsburgh in 2018, the same year the property was added to the National Register of Historic Places. It is currently being renovated to house the UPMC Immune Transplant and Therapy Center, a collaboration between the university and UPMC. The center is scheduled to open in 2022.

Ellsworth Avenue is located in the Shadyside neighborhood of Pittsburgh, Pennsylvania. It is mostly a commercial street that has locally owned businesses, galleries, restaurants, and bars. It runs southwest-northeast, parallel to Walnut Street, another commercial street, and is bounded by Shady Avenue to the east and South Neville Street to the west. Ellsworth Avenue is one of Shadyside's three business districts, along with South Highland Avenue and Walnut Street.Several Pittsburgh Historic Landmarks line Ellsworth Avenue. At the corner of Neville and Ellsworth is the Church of the Ascension, an episcopalian church that was named a landmark in 1971. Colonial Place is a mansion designed by George S. Orth that became a landmark in 1898. Roslyn Place (a wood-paved street) and Ellsworth Terrace are also landmarks located here.

Shadyside Presbyterian Church is a large congregation of the Presbyterian Church (U.S.A.) in an historic part of Pittsburgh, Pennsylvania, United States. Located at the corner of Amberson Avenue and Westminster Place in the Shadyside neighborhood, Shadyside Presbyterian Church was founded in 1866 as a congregation in the Presbyterian Church in the U.S.A. and has enjoyed a long history of local, national, and global recognition for its outreach and service. The Shadyside church building is listed on the National Register of Historic Places as a prime example of Richardsonian Romanesque architecture. It was completed in 1890 to designs of American architectural firm Shepley, Rutan & Coolidge, the successor firm to H.H. Richardson's own office.Throughout its long history, the church has been served by a succession of notable preachers, including Hugh Thomson Kerr Sr., Robert Cleveland Holland, Howard C. Scharfe, and F. Morgan Roberts. Between 2003 and 2012, the congregation had as its senior pastor M. Craig Barnes, noted author and speaker, and professor at Pittsburgh Theological Seminary, until his election as president of Princeton Theological Seminary. Conrad C. Sharps served as senior pastor 2014–2018. The Rev. Dr. John Allan Dalles, a well-known hymn writer, Pittsburgh native, and graduate of Pittsburgh Theological Seminary, was the church's Interim Senior Minister and Head of Staff, 2019–2021. The current pastor, the twelfth in the church's history, is the Reverend Austin Crenshaw Shelley. It was here, in 1933 that the now global practice of celebrating World Communion Sunday on the first Sunday in October was originated, under the leadership of The Rev. Dr. Hugh Thomson Kerr. It also was the first church anywhere to pioneer regular radio broadcasts of its worship, on KDKA, the first commercially licensed radio station in the United States, and was the first church to broadcast worship to both the North Pole and to the South Pole.

Negley–Gwinner–Harter House (also known as Gwinner–Harter House, and William B. Negley House) located at 5061 Fifth Avenue in the Shadyside neighborhood of Pittsburgh, Pennsylvania, was built from 1870 to 1871 for William B. Negley (June 5, 1828 – January 16, 1894, a lawyer who attended Princeton University, served as a Major in the American Civil War under General James S. Negley, and was the son of Jacob Negley and the nephew of Sarah Negley and Thomas Mellon). After Joanna Wilmerding (Bruce) Negley, the widow of William B. Negley, died in 1910, Edward Gwinner, a stone and railroad contractor, purchased the property in 1911. Gwinner had it remodeled and expanded. The original architect is unknown, but Frederick J. Osterling remodeled the house and was responsible for additions between 1912 and 1923. Gwinner died in 1949, and his widow, Adele, owned it until 1963, when the house was sold to Dr. Leo Harter. In 1987, a fire caused by a paint-stripping gun during renovation burned much of the third floor and damaged the roof. Harter died in 1988, and the house sat vacant for eight years, was boarded up, and had even been considered for demolition. Then in 1995, restoration contractor Joedda Sampson and her husband Ben, a builder and developer, purchased the property and restored it. The restoration took nine months. In 2002, the house was purchased by Kenneth Lehn and Marina Persic Lehn. According to the Allegheny County Pennsylvania Real Estate Assessment Page, the house's estimated previous year market value for 2010 was $1,110,800. This Second Empire style house was added to the List of Pittsburgh History and Landmarks Foundation Historic Landmarks in 2000.

The McCook Family Estate (also known as the Willis McCook House) is a historic mansion located at 5105 Fifth Avenue in the Shadyside neighborhood of Pittsburgh, Pennsylvania, USA. It was built during 1906 and 1907 for Willis McCook and his family. McCook was a prominent businessman and lawyer who represented Henry Clay Frick.

The Moreland-Hoffstot House in the Shadyside neighborhood of Pittsburgh, Pennsylvania is a building from 1914. It was listed on the National Register of Historic Places in 1978.