University of Pennsylvania Campus Historic District

The Hospital of the University of Pennsylvania (HUP) is the flagship hospital of Penn Medicine and is located in the University City section of West Philadelphia. It is consistently ranked as one of the top hospitals in the United States.

The Children's Hospital of Philadelphia (CHOP) is a children's hospital in Philadelphia, Pennsylvania, with its primary campus located in the University City neighborhood of West Philadelphia in the campus of the University of Pennsylvania. The hospital has 594 beds and more than 1 million outpatient and inpatient visits each year. It is one of the largest and oldest children's hospitals in the world, and United States' first hospital dedicated to the healthcare of children. CHOP has been ranked as the best children's hospital in the United States by U.S. News & World Report and Parents Magazine in recent years. As of 2020, it was ranked number one in the nation by U.S. News for three out of ten specialties. The hospital treats infants, children, teens, and young adults aged 0–21. The hospital also treats adults that would benefit from advanced pediatric care. The hospital is located next to the University of Pennsylvania and its physicians serve as the pediatrics department of the Perelman School of Medicine at the University of Pennsylvania.

The Ruth and Raymond Perelman Center for Advanced Medicine is a specialized medical facility located at 34th Street and Civic Center Boulevard, on the former site of the Philadelphia Civic Center, on the campus of the Hospital of the University of Pennsylvania. The $302-million project was designed by Rafael Viñoly Architects and completed in 2008. It was the largest capital project ever undertaken by the University of Pennsylvania Health System, until the construction of The Pavilion.The center is home to Penn Medicine's Abramson Cancer Center, radiation oncology, cardiovascular medicine and an outpatient surgical pavilion. One of the most important parts of the Center for Advanced Medicine is the Roberts Proton Therapy Center which houses the largest proton therapy center associated with a medical center in the world. The proton therapy center will be used by both the Walter Reed Army Medical Center and the Children's Hospital of Philadelphia, as well as the Penn Medicine to treat cancer patients.

Houston Hall is the student union of the University of Pennsylvania, in Philadelphia, Pennsylvania. Completed in 1896, it was the first student union built on an American college campus.Houston Hall was listed as a National Register of Historic Places contributing property in the University of Pennsylvania Campus Historic District in 1978.

The Philadelphia Convention Hall and Civic Center—more commonly known as the Philadelphia Civic Center and the Philadelphia Convention Center, and formerly known as Municipal Auditorium and the Philadelphia Convention Hall—located in Philadelphia, in the U.S. state of Pennsylvania, was a complex of five or more buildings developed out of a series of buildings dedicated to expanding trade which began with the National Export Exhibition in 1899. There were two important buildings on the site. The Commercial Museum, built in 1899, was one of the original exposition buildings. The Municipal Auditorium (Convention Hall) was built in 1931; Philip H. Johnson was the architect. The site was host to national political conventions in 1900, 1936, 1940 and 1948.

The Academy and College of Philadelphia (1749-1791) was a boys' school and men's college in Philadelphia, Colony of Pennsylvania. Founded in 1749 by a group of local notables that included Benjamin Franklin, the Academy of Philadelphia began as a private secondary school, occupying a former religious school building at the southwest corner of 4th and Arch Streets. The academy taught reading, writing, and arithmetic to both paying and charity students. The College of Philadelphia was founded in 1755, when the academy's charter was amended to allow the granting of advanced academic degrees. The Medical School of the College of Philadelphia, founded in 1765, was the first medical school in North America. The College of Philadelphia merged with the University of the State of Pennsylvania in 1791, to form the University of Pennsylvania.

The Center for Applied Genomics is a research center at the Children's Hospital of Philadelphia that focuses on genomics research and the utilization of basic research findings in the development of new medical treatments. It is one of the world's largest genetics research and analytical facilities. It is the primary center at a pediatric hospital with access to high-throughput genotyping technology, and has processed genetic samples from over 100,000 people. The center is focused on detecting the genetic causes of prevalent childhood diseases including (but not limited to) asthma, obesity, ADHD, autism, diabetes, inflammatory bowel disease, epilepsy, schizophrenia, and pediatric cancer, all of which are thought to involve multiple, interacting genes within the body.

The Joseph H. Lauder Institute of Management & International Studies (The Lauder Institute) offers a joint degree program at the University of Pennsylvania, combining an MA in international studies from the School of Arts & Sciences with an MBA from The Wharton School or JD from the Law School. Students pursue one of six Programs of Concentration focused on five regional areas (Africa, East and Southeast Asia, Europe, Latin America, or South Asia, the Middle East and North Africa) or the Global Program. Within the regional Programs of Concentration, students must attain superior language proficiency based upon an oral proficiency interview certified by Language Testing International in either Arabic, Chinese, French, German, Hindi, Japanese, Korean, Portuguese, Russian, or Spanish. Each year 60-70 students from around the world join the Lauder Program in May starting in Philadelphia before departing on an 8-week summer immersion to their respective regions of study. Students return to campus in August to join the MBA or JD program and then graduate with their class two years later. In the most recent incoming class, 60% of the class were US Citizens and 40% were international or dual citizens.

College Hall is the oldest building on the West Philadelphia campus of the University of Pennsylvania. Prior to its construction, the university was located on Ninth Street in Center City, Philadelphia. The building was designed by Thomas Webb Richards and completed in 1873. The characteristic green color of the building is due to its composition of green serpentine stone. College Hall was placed on the National Register of Historic Places February 14, 1978. It is also a contributing property of the University of Pennsylvania Campus Historic District. The building currently houses the undergraduate admissions office, the university president's offices, the Department of History, and classrooms. The top floor of College Hall is also home to the Philomathean Society, a literary society founded in 1813. Although College Hall and the now-demolished Blanchard Hall were rumored to be the model for the Victorian Gothic mansion in The Addams Family cartoons, the cartoonist Charles Addams repeatedly denied the claims.

The Curtis Organ, named for publisher Cyrus H.K. Curtis, is one of the largest pipe organs in the world with 162 ranks and 10,731 pipes. The concert organ, of American Symphonic design, was manufactured by the Austin Organ Company as its Opus 1416 in 1926 for the Philadelphia Sesquicentennial Exposition. It was known as the "Organists' Organ" because the specifications were formulated by Henry S. Fry, John M'E. Ward, Rollo F. Maitland, Frederick Maxson, and S. Wesley Sears, all prominent Philadelphia organists.Curtis acquired the instrument after the Exposition went bankrupt and donated it to the University of Pennsylvania, where it was divided into two halves and incorporated into Irvine Auditorium at the time of the building's construction. The organ contains the largest Universal Air Chest ever built by Austin. In its original configuration in the Auditorium building, the organ spread 75 feet across its platform at the Sesquicentennial Exposition. This pressurized room under the pipes allows access to the organ's pneumatic mechanisms while it is playing, and was touted as being able to seat 100 people to dinner comfortably. The organ's mechanical actions were renewed in the 1950s through the generosity of Mary Louise Curtis Bok Zimbalist, daughter of Cyrus H.K. Curtis and founder of The Curtis Institute of Music. In the later 1980s and early 1990s, the organ was connected to a customized MIDI interface, making it, at that time, the world's largest MIDI-capable instrument. In more recent times, the Austin Organ Company carried out a complete mechanical restoration of the organ (with a new console and relay system added), carefully preserving the organ's tonal integrity. It was rededicated in October 2002. In October 1972 Keith Chapman accompanied the Lon Chaney silent film "[The Phantom of the Opera]" as a fund-raiser for the organ that evolved into an annual campus Halloween event. Cyrus Curtis also gave an Austin organ to nearby Drexel University, and to the auditorium of City Hall in Portland, Maine.

Irvine Auditorium is a performance venue at 3401 Spruce Street on the campus of the University of Pennsylvania, in Philadelphia. It was designed by the firm of prominent Philadelphia area architect Horace Trumbauer and built 1926–1932. Irvine Auditorium is notable for its nearly 11,000-pipe Curtis Organ, the world's 22nd-largest pipe organ (by ranks), originally built for the Sesquicentennial Exposition of 1926 and donated to the university in 1928. The building was opened in May, 1929. A persistent but untrue campus legend holds that the building was a Penn architecture student's design project that received a failing grade. He was forced to give up architecture to go into business, where he amassed a fortune. Years later, he made a major bequest to the university in his will, but only on the condition that his project be built. Seating capacity is 1,260. (Prior to renovation the seating capacity was 1,976.) The octagonal auditorium featured side balconies that faced each other, at right angles to the stage. The building was restored and renovated in 1997–2000 by Venturi, Scott Brown & Associates, Inc, who removed the side balconies to improve the acoustic quality, as well as to create more intimate performance spaces.

The Wistar Institute is an independent, nonprofit research institution in biomedical science, with special expertise in oncology, immunology, infectious disease and vaccine research. Located on the campus of the University of Pennsylvania, Wistar was founded in 1892 as America's first nonprofit institution solely focused on biomedical research and training. The institute has historic and contemporary ties with the university, reflected in research collaboration and shared access to facilities.Since 1972, Wistar has been a National Cancer Institute (NCI)-designated cancer center. It has received the highest rating of "exceptional" in two consecutive terms in 2013 and 2018 by the Cancer Center Support Grant.Known worldwide for vaccine development, some of the institute's accomplishments are its contributions to the creation of vaccines for rubella (German Measles), rotavirus and rabies.