Buerger Center for Advanced Pediatric Care

The Ruth and Raymond Perelman Center for Advanced Medicine is a specialized medical facility located at 34th Street and Civic Center Boulevard, on the former site of the Philadelphia Civic Center, on the campus of the Hospital of the University of Pennsylvania. The $302-million project was designed by Rafael Viñoly Architects and completed in 2008. It was the largest capital project ever undertaken by the University of Pennsylvania Health System, until the construction of The Pavilion.The center is home to Penn Medicine's Abramson Cancer Center, radiation oncology, cardiovascular medicine and an outpatient surgical pavilion. One of the most important parts of the Center for Advanced Medicine is the Roberts Proton Therapy Center which houses the largest proton therapy center associated with a medical center in the world. The proton therapy center will be used by both the Walter Reed Army Medical Center and the Children's Hospital of Philadelphia, as well as the Penn Medicine to treat cancer patients.

The Perelman School of Medicine, commonly known as Penn Med, is the medical school of the University of Pennsylvania, a private research university in Philadelphia, Pennsylvania. Founded in 1765, the Perelman School of Medicine is the oldest medical school in the United States and is one of the seven Ivy League medical schools. Penn Med is consistently one of the top recipients of NIH research awards and is currently ranked sixth for research among American medical schools by U.S. News & World Report.

The Children's Hospital of Philadelphia (CHOP) is a children's hospital in Philadelphia, Pennsylvania, with its primary campus located in the University City neighborhood of West Philadelphia in the campus of the University of Pennsylvania. The hospital has 594 beds and more than 1 million outpatient and inpatient visits each year. It is one of the largest and oldest children's hospitals in the world, and United States' first hospital dedicated to the healthcare of children. CHOP has been ranked as the best children's hospital in the United States by U.S. News & World Report and Parents Magazine in recent years. As of 2020, it was ranked number one in the nation by U.S. News for three out of ten specialties. The hospital treats infants, children, teens, and young adults aged 0–21. The hospital also treats adults that would benefit from advanced pediatric care. The hospital is located next to the University of Pennsylvania and its physicians serve as the pediatrics department of the Perelman School of Medicine at the University of Pennsylvania.

The University of Pennsylvania Campus Historic District is a historic district on the campus of the University of Pennsylvania, in Philadelphia, Pennsylvania, USA. The university relocated from Center City to West Philadelphia in the 1870s, and its oldest buildings date from that period. The Historic District was added to the National Register of Historic Places on December 28, 1978. In 1978, the Historic District comprised 28 contributing properties over 117 acres (0.47 km2). One of them, the Lea Laboratory of Hygiene ("Smith Labs"), was demolished in 1995. Three contributing properties within the Historic District — College Hall, Furness Library, and Richards Medical Research Laboratories — are separately listed on the NRHP. St. Anthony Hall House is adjacent to the Historic District, and was listed on the NRHP in 2005.

The Hospital of the University of Pennsylvania (HUP) is the flagship hospital of Penn Medicine and is located in the University City section of West Philadelphia. It is consistently ranked as one of the top hospitals in the United States.

The Philadelphia Convention Hall and Civic Center—more commonly known as the Philadelphia Civic Center and the Philadelphia Convention Center, and formerly known as Municipal Auditorium and the Philadelphia Convention Hall—located in Philadelphia, in the U.S. state of Pennsylvania, was a complex of five or more buildings developed out of a series of buildings dedicated to expanding trade which began with the National Export Exhibition in 1899. There were two important buildings on the site. The Commercial Museum, built in 1899, was one of the original exposition buildings. The Municipal Auditorium (Convention Hall) was built in 1931; Philip H. Johnson was the architect. The site was host to national political conventions in 1900, 1936, 1940 and 1948.

The University of Pennsylvania Museum of Archaeology and Anthropology—commonly known as the Penn Museum—is an archaeology and anthropology museum associated with the University of Pennsylvania. It is located on Penn's campus in the University City neighborhood of Philadelphia, at the intersection of 33rd and South Streets. Housing over 1.3 million artifacts, the museum features one of the most comprehensive collections of middle and near-eastern art in the world.

The Graduate Group in the Art and Archaeology of the Mediterranean World (AAMW) is an interdisciplinary program for research and teaching of archaeology, particularly archaeology and art of the ancient Mediterranean (Greece and Rome), Egypt, Anatolia, and the Near East, based in the Penn Museum of the University of Pennsylvania.

The institution now known as the University of Pennsylvania was founded as a secondary school in 1740 and by the time of the American Revolution had grown to include a college and medical school called the College of Philadelphia. While it operated under a state charter, it was a private institution with its own board of trustees. Many were Loyalists, and when the revolutionary government of Pennsylvania regained control of the city of Philadelphia after the British occupation of 1777-8, it rechartered the institution as the "University of the State of Pennsylvania," appointed new trustees, and dismissed Provost William Smith. Following repeated lawsuits by Smith and the original trustees, the state restored the College's charter in 1789, but the University continued to operate on the original campus. The two competing institutions merged in 1791, forming the University of Pennsylvania.

The Center for Applied Genomics is a research center at the Children's Hospital of Philadelphia that focuses on genomics research and the utilization of basic research findings in the development of new medical treatments. It is one of the world's largest genetics research and analytical facilities. It is the primary center at a pediatric hospital with access to high-throughput genotyping technology, and has processed genetic samples from over 100,000 people. The center is focused on detecting the genetic causes of prevalent childhood diseases including (but not limited to) asthma, obesity, ADHD, autism, diabetes, inflammatory bowel disease, epilepsy, schizophrenia, and pediatric cancer, all of which are thought to involve multiple, interacting genes within the body.

Penn Medicine station (formerly University City station) is a train station in the University City section of Philadelphia, Pennsylvania on the SEPTA Regional Rail system. The station serves the area around the University of Pennsylvania, and is located at South Street and Convention Avenue. Located on the West Chester Branch, it serves the Airport, Wilmington/Newark, Media/Wawa, Manayunk/Norristown, Warminster, and West Trenton Regional Rail services. In 2013, this station saw 3,091 boardings and 2,950 alightings on an average weekday.The station is less than a block from the University of Pennsylvania's Franklin Field and the Palestra. It is one block away from the medical campuses of the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia. The rest of the University of Pennsylvania campus, Drexel University campus, and the Graduate Hospital campus and the neighborhood across the Schuylkill River are also nearby and easily accessible.

The Curtis Organ, named for publisher Cyrus H.K. Curtis, is one of the largest pipe organs in the world with 162 ranks and 10,731 pipes. The concert organ, of American Symphonic design, was manufactured by the Austin Organ Company as its Opus 1416 in 1926 for the Philadelphia Sesquicentennial Exposition. It was known as the "Organists' Organ" because the specifications were formulated by Henry S. Fry, John M'E. Ward, Rollo F. Maitland, Frederick Maxson, and S. Wesley Sears, all prominent Philadelphia organists.Curtis acquired the instrument after the Exposition went bankrupt and donated it to the University of Pennsylvania, where it was divided into two halves and incorporated into Irvine Auditorium at the time of the building's construction. The organ contains the largest Universal Air Chest ever built by Austin. In its original configuration in the Auditorium building, the organ spread 75 feet across its platform at the Sesquicentennial Exposition. This pressurized room under the pipes allows access to the organ's pneumatic mechanisms while it is playing, and was touted as being able to seat 100 people to dinner comfortably. The organ's mechanical actions were renewed in the 1950s through the generosity of Mary Louise Curtis Bok Zimbalist, daughter of Cyrus H.K. Curtis and founder of The Curtis Institute of Music. In the later 1980s and early 1990s, the organ was connected to a customized MIDI interface, making it, at that time, the world's largest MIDI-capable instrument. In more recent times, the Austin Organ Company carried out a complete mechanical restoration of the organ (with a new console and relay system added), carefully preserving the organ's tonal integrity. It was rededicated in October 2002. In October 1972 Keith Chapman accompanied the Lon Chaney silent film "[The Phantom of the Opera]" as a fund-raiser for the organ that evolved into an annual campus Halloween event. Cyrus Curtis also gave an Austin organ to nearby Drexel University, and to the auditorium of City Hall in Portland, Maine.