Caribbean Cultural Center African Diaspora Institute

The Columbus Theatre was a theatre located at 114 E. 125th Street between Park Avenue and Lexington Avenue. It was the second theatre built by theatre impresario Oscar Hammerstein I. The architects were J. B. McElfatrick & Sons.The Columbus Theatre originally sat 1,649 people and was a major venue for musical theatre, vaudeville, and minstrel shows in Upper Manhattan. The theatre also occasionally served as an opera house, and sometimes presented plays ranging from classic works by William Shakespeare to new plays written by Americans. It opened in October 1890. The theatre was sold to F. F. Proctor in 1899 and was then renamed Proctor's 125th Street Theatre. It was later re-titled Keith & Proctor's 125th Street Theatre about a year later when Proctor formed a partnership with Benjamin Franklin Keith. After that partnership fell apart in 1911, it was once again known as Proctor's 125th Street Theatre or simply Proctor's Theatre. It was purchased by RKO sometime in the 1930s, and operated as a move theatre entitled RKO Proctor's 125th Street Theatre until it closed in 1957.

Arthur F. Collins (1937 – October 9, 1965) was a 28-year-old man who was murdered in a New York City subway after defending two women being assaulted by an intoxicated man. Collins's wife soon obtained employment, but in order to work, she had to send their daughter to live with relatives in Europe. Less than two months after Collins's wife was widowed, public outcry resulted in New York City Mayor Wagner signing a "good Samaritan" bill into law. In August 1966, New York State Governor Nelson Rockefeller signed into law a bill that would provide state compensation to eligible crime victims. Rockefeller said this law was the result of the murder of Collins. This law transitioned to the formation of the New York State Office of Victims Services, an agency that provides compensation to all innocent victims of all crimes.

The 125th Street station is an express station with four tracks and two island platforms. It is the northernmost Manhattan station on the IRT Lexington Avenue Line of the New York City Subway. Located at Lexington Avenue and East 125th Street (also known as Dr. Martin Luther King, Jr. Boulevard) in East Harlem, it is served by the 4 and 6 trains at all times, the 5 train at all times except late nights, and the <6> train during weekdays in peak direction. This station was constructed as part of the Dual Contracts by the Interborough Rapid Transit Company and opened in 1918. A planned northern extension of the Second Avenue Subway would connect with this station and with the Metro-North Railroad's Harlem–125th Street station, located one block west.

The National Jazz Museum in Harlem is a museum dedicated to preservation and celebration of the jazz history of Harlem, Manhattan, New York City. The idea for the museum was conceived in 1995. The museum was founded in 1997 by Leonard Garment, counsel to two U.S. presidents, and an accomplished jazz saxophonist, Abraham David Sofaer, a former U.S. district judge who gave the initial gift in honor of his brother-in-law Richard J. Scheuer, Jr., and matching funds from the Upper Manhattan Empowerment Zone Development Corporation. For more than 15 years, the museum was based in East Harlem at 104 East 126th Street. On February 1, 2016, the museum re-opened in a new space on the ground floor of 58 West 129th Street in Central Harlem with approximately 1900 square feet of exhibition space.

The Harlem–125th Street station is a commuter rail stop serving the Metro-North Railroad's Hudson, Harlem, and New Haven Lines. It is located at East 125th Street and Park Avenue in East Harlem, Manhattan, New York City. The station also serves as an important transfer point between the Metro-North trains and the New York City Subway's IRT Lexington Avenue Line (4, ​5, ​6, and <6> trains) for access to the Upper East Side of Manhattan. It is the only station besides Grand Central Terminal that serves all three lines east of the Hudson River. Trains leave for Grand Central Terminal, as well as to the Bronx and the northern suburbs, regularly.

The Mount Morris Bank Building, also referred to as the Corn Exchange Bank (Mount Morris Branch) and Corn Exchange Building, is an historic building in the East Harlem neighborhood of Manhattan, New York City, located at 81-85 East 125th Street on the northwest corner of Park Avenue. Although an architectural standout when new in 1883, by the late 1970s it was vacant, and remained so for three decades, vandalized and deteriorating. In 2009 the city demolished, for safety, most of what remained after a 1997 fire, but in 2012 a developer undertook to rebuild it for commercial occupancy, and the building reopened in May 2015. The building was added to the National Register of Historic Places in 1989, and was designated a New York City Landmark in 1993.

Sawyer Memorial Universalist Church was a historic church in Harlem, New York.The Second Universalist Society was organized early in the 19th century, and in 1832 acquired the Reformed Dutch Church at 97 Orchard Street. This church was torn down three decades later, and the society was in Oliver Street for a few years. Following the Civil War, the congregation moved in 1869 to Harlem where they met in a building on East 127th Street at the corner of Lexington Avenue. A new stone church was erected in 1879. At some point, the society merged or disbanded, and in 1889 the property became the Swedish Mission Chapel of St. Bartholomew's Episcopal Church.

The New York College of Podiatric Medicine (NYCPM) is a private podiatric medical college in Manhattan, New York. It is the oldest and second largest podiatric medical school in the United States.

The Elmendorf Reformed Church, formerly known as the Elmendorf Chapel, is a historic Reformed Church in America (RCA) church located at 171 East 121st Street between Sylvan Court and Third Avenue in the Harlem neighborhood of Manhattan, New York City. It was founded as a parish house and Sunday school for the First Collegiate Church of Harlem, which had its beginnings in 1660 as the Low Dutch Reformed Church of Harlem or Harlem Reformed Dutch Church, the first house of worship in Harlem. The Church's original burying ground for its African American congregants was discovered in 2008 at the 126th Street Depot of the MTA Regional Bus Operations when body parts were found upon digging at the location. The Metropolitan Transportation Authority agreed to move the Depot by 2015. Sanctuaries were built in 1665–67, 1686–87, 1825 and 1897, at various locations in the area. In 1893-94 a Neoclassical parish house was built on this site under the auspices of Rev. Joachim Elmendorf, designed by Joseph Ireland. Around 1910, the church at the time was torn down, and the parish house was rebuilt as the Elmendorf Chapel, which then became the Elmendorf Reformed Church. It is the oldest congregation in Harlem.The church is a two-story plus basement building which is "L" shaped in plan and fills much of its 53 feet wide by 120 feet deep lot.The church was listed on the National Register of Historic Places in 2010.On September 22, 2002, Patricia A. Singletary became the first female minister of the Elmendorf Reformed Church. The Elmendorf Reformed Church was organized in 1660 as the Harlem Reformed Low Dutch Church[5][6][7]

Henry J. Carter Specialty Hospital and Nursing Facility, also known as NYC Health + Hospitals/Carter is a long-term acute care hospital (LTACH) located in East Harlem, New York City that was opened in 2013 by the New York City Health and Hospitals corporation.

The Children's Storefront was a tuition-free private school in Harlem, founded in 1966 by the poet Ned O'Gorman. It was the subject of a 1988 documentary film, The Children's Storefront, nominated for an Academy Award for Best Documentary Short.

The Harlem Courthouse at 170 East 121st Street on the corner of Sylvan Place – a remnant of the former Boston Post Road – in the Harlem neighborhood of Manhattan, New York City, was built in 1891-93 and was designed by Thom & Wilson in the Romanesque Revival style. The brick, brownstone, bluestone, granite and terra cotta building features gables, archways, an octagonal corner tower and a two-faced clock. It was built for the Police and District Courts, but is now used by other city agencies. In 1936, during the New Deal, Federal Art Project artist David Karfunkle painted a mural, "Exploitation of Labor and Hoarding of Wealth" on its third floor.The city government used the building as a laboratory to measure air pollution. At the time of the 1966 New York City smog, it was the city's only station to measure the air.The building was designated a New York City landmark in 1967, and was added to the National Register of Historic Places in 1980.