Henry J. Carter Specialty Hospital and Nursing Facility

North General Hospital (NGH) was an American private, not-for-profit, voluntary teaching hospital located in New York City in the East Harlem section of Manhattan at Marcus Garvey Park. It was founded in 1979 to replace, as tenant, the Hospital for Joint Diseases (HJD), which vacated its East Harlem facility and moved that same year downtown to East 17th street at Stuyvesant Square. NGH was the only minority-run, voluntary teaching hospital in the State of New York. NGH was also the only private (non-public) hospital in Harlem. After 31 years, North General Hospital closed in 2010 under financial duress of bankruptcy.

The New York College of Podiatric Medicine (NYCPM) is a private podiatric medical college in Manhattan, New York. It is the oldest and second largest podiatric medical school in the United States.

Helene Fuld College of Nursing is a private nursing school in Manhattan, New York City. The college offers associate and comprehensive baccalaureate science degrees to Licensed Practical Nurses, Registered Nurses, and individuals who are not already nurses. The college is located in the East Harlem section of Manhattan in the Mount Morris Park Historic District across from Marcus Garvey Park. It was founded seventy-seven years ago in 1945.

The Harlem Courthouse at 170 East 121st Street on the corner of Sylvan Place – a remnant of the former Boston Post Road – in the Harlem neighborhood of Manhattan, New York City, was built in 1891-93 and was designed by Thom & Wilson in the Romanesque Revival style. The brick, brownstone, bluestone, granite and terra cotta building features gables, archways, an octagonal corner tower and a two-faced clock. It was built for the Police and District Courts, but is now used by other city agencies. In 1936, during the New Deal, Federal Art Project artist David Karfunkle painted a mural, "Exploitation of Labor and Hoarding of Wealth" on its third floor.The city government used the building as a laboratory to measure air pollution. At the time of the 1966 New York City smog, it was the city's only station to measure the air.The building was designated a New York City landmark in 1967, and was added to the National Register of Historic Places in 1980.

The Harlem Fire Watchtower, also known as the Mount Morris Fire Watchtower, is the only surviving one of eleven cast-iron watchtowers placed throughout New York City starting in the 1850s. Standing at 47 feet (14 m) tall, it was built by Julius H. Kroehl for $2,300 based on a design by James Bogardus. It is located in Marcus Garvey Park in Harlem, Manhattan. The Mount Morris Park tower went into service in 1857 in response to Harlem residents’ demand. The towers gave volunteers a perch from which to watch for fires that were common in the wooden structures that then made up much of New York City, and the watchers then spread the word via bell ringing. Later, electric telegraphs were installed but the bell provided local alarms. When pull boxes and other technological advances rendered the fire watchtowers obsolete, the system was discontinued and the other towers eventually were destroyed. Harlem's, protected in the middle of a park, endured. During the New Deal, the area surrounding the watchtower was rebuilt by government employees as part of the Works Project Administration jobs program. This project created a gracious plaza (sometimes called "the Acropolis"), stone retaining wall, and wide steps approaching the summit from several sides for pedestrians. The tower was designated a city landmark in 1967 and was listed on the National Register of Historic Places in 1976. The last work on the watchtower came in 1994, but cracks in the overall structure and in the bell remained. The granite parapet along the top was in need of restoration. Weather, lack of maintenance, and neglect took their toll over the years. Roof damage allowed water into the structure, rusting structural members. The original copper roof deteriorated and fell off, exposing the interior to more damage. Many of the internal steps were missing and park visitors may no longer climb them or get near the structure, which is protected by a fence. In 2013, the Mount Morris Park Community Improvement Association and the Marcus Garvey Park Alliance partnered with the New York City Department of Parks and Recreation to raise $4 million to restore the Harlem Watchtower, led by Valerie Jo Bradley. Starting in late 2014, NYC Parks disassembled the tower to restore the structure and ensure its soundness and stability before reconstruction. The tower reopened to visitors in December 2019.

The Mount Morris Bank Building, also referred to as the Corn Exchange Bank (Mount Morris Branch) and Corn Exchange Building, is an historic building in the East Harlem neighborhood of Manhattan, New York City, located at 81-85 East 125th Street on the northwest corner of Park Avenue. Although an architectural standout when new in 1883, by the late 1970s it was vacant, and remained so for three decades, vandalized and deteriorating. In 2009 the city demolished, for safety, most of what remained after a 1997 fire, but in 2012 a developer undertook to rebuild it for commercial occupancy, and the building reopened in May 2015. The building was added to the National Register of Historic Places in 1989, and was designated a New York City Landmark in 1993.

The Columbus Theatre was a theatre located at 114 E. 125th Street between Park Avenue and Lexington Avenue. It was the second theatre built by theatre impresario Oscar Hammerstein I. The architects were J. B. McElfatrick & Sons.The Columbus Theatre originally sat 1,649 people and was a major venue for musical theatre, vaudeville, and minstrel shows in Upper Manhattan. The theatre also occasionally served as an opera house, and sometimes presented plays ranging from classic works by William Shakespeare to new plays written by Americans. It opened in October 1890. The theatre was sold to F. F. Proctor in 1899 and was then renamed Proctor's 125th Street Theatre. It was later re-titled Keith & Proctor's 125th Street Theatre about a year later when Proctor formed a partnership with Benjamin Franklin Keith. After that partnership fell apart in 1911, it was once again known as Proctor's 125th Street Theatre or simply Proctor's Theatre. It was purchased by RKO sometime in the 1930s, and operated as a move theatre entitled RKO Proctor's 125th Street Theatre until it closed in 1957.

The Harlem–125th Street station is a commuter rail stop serving the Metro-North Railroad's Hudson, Harlem, and New Haven Lines. It is located at East 125th Street and Park Avenue in East Harlem, Manhattan, New York City. The station also serves as an important transfer point between the Metro-North trains and the New York City Subway's IRT Lexington Avenue Line (4, ​5, ​6, and <6> trains) for access to the Upper East Side of Manhattan. It is the only station besides Grand Central Terminal that serves all three lines east of the Hudson River. Trains leave for Grand Central Terminal, as well as to the Bronx and the northern suburbs, regularly.

Marcus Garvey Park (formerly and also named Mount Morris Park) is a 20.16-acre (81,600 m2) park on the border between the Harlem and East Harlem neighborhoods of Manhattan, New York City. The park, centered on a massive and steep outcropping of schist, interrupts the flow of Fifth Avenue traffic, which is routed around the park via Mount Morris Park West. The park is also bounded by 120th Street to the south, 124th Street to the north, and Madison Avenue to the east. The park was created in 1840 and was originally named for Robert Morris, then the mayor of New York City. It was renamed after black activist and businessman Marcus Garvey in 1973. Marcus Garvey Park contains flat lawns and playing fields surrounding the schist outcropping, as well as the Harlem Fire Watchtower, a New York City designated landmark. It is operated and maintained by the New York City Department of Parks and Recreation.

The Elmendorf Reformed Church, formerly known as the Elmendorf Chapel, is a historic Reformed Church in America (RCA) church located at 171 East 121st Street between Sylvan Court and Third Avenue in the Harlem neighborhood of Manhattan, New York City. It was founded as a parish house and Sunday school for the First Collegiate Church of Harlem, which had its beginnings in 1660 as the Low Dutch Reformed Church of Harlem or Harlem Reformed Dutch Church, the first house of worship in Harlem. The Church's original burying ground for its African American congregants was discovered in 2008 at the 126th Street Depot of the MTA Regional Bus Operations when body parts were found upon digging at the location. The Metropolitan Transportation Authority agreed to move the Depot by 2015. Sanctuaries were built in 1665–67, 1686–87, 1825 and 1897, at various locations in the area. In 1893-94 a Neoclassical parish house was built on this site under the auspices of Rev. Joachim Elmendorf, designed by Joseph Ireland. Around 1910, the church at the time was torn down, and the parish house was rebuilt as the Elmendorf Chapel, which then became the Elmendorf Reformed Church. It is the oldest congregation in Harlem.The church is a two-story plus basement building which is "L" shaped in plan and fills much of its 53 feet wide by 120 feet deep lot.The church was listed on the National Register of Historic Places in 2010.On September 22, 2002, Patricia A. Singletary became the first female minister of the Elmendorf Reformed Church. The Elmendorf Reformed Church was organized in 1660 as the Harlem Reformed Low Dutch Church[5][6][7]

The Caribbean Cultural Center African Diaspora Institute (CCCADI) is a nonprofit organization based in East Harlem in New York City that serves as an Afro-Caribbean center of culture and community for members of the African diaspora.

The Church of St. Paul is a Roman Catholic parish church in the Roman Catholic Archdiocese of New York, located in the East Harlem neighborhood of Manhattan, New York City. The sixth parish established in New York City, it was designated a New York City Landmark on June 28, 2016.