Elmendorf Reformed Church

The Harlem Courthouse at 170 East 121st Street on the corner of Sylvan Place – a remnant of the former Boston Post Road – in the Harlem neighborhood of Manhattan, New York City, was built in 1891-93 and was designed by Thom & Wilson in the Romanesque Revival style. The brick, brownstone, bluestone, granite and terra cotta building features gables, archways, an octagonal corner tower and a two-faced clock. It was built for the Police and District Courts, but is now used by other city agencies. In 1936, during the New Deal, Federal Art Project artist David Karfunkle painted a mural, "Exploitation of Labor and Hoarding of Wealth" on its third floor.The city government used the building as a laboratory to measure air pollution. At the time of the 1966 New York City smog, it was the city's only station to measure the air.The building was designated a New York City landmark in 1967, and was added to the National Register of Historic Places in 1980.

The CUNY Graduate School of Public Health & Health Policy (commonly known as the CUNY School of Public Health, or CUNY SPH) is a public American research and professional college within the borders of City University of New York (CUNY) system of colleges. The school is situated at 55 West 125th Street in Manhattan. CUNY SPH offers doctoral programs, master's programs, several certificates, and faculty memberships in many of CUNY's research centers and institutes. A core roster of over 50 full-time faculty is supplemented by additional faculty members drawn from throughout CUNY.

St. Johannes Kirche was a former Lutheran church located at 217 East 119th Street between Second and Third Avenues in East Harlem, Manhattan, New York City. It was built in 1873 and reused as Iglesia Luterana Sion by the Lutheran Church in America: “An early masonry church for this community, then remote from the center of the city much further downtown. The church began as a home for a German-speaking congregation—today it serves those who speak Spanish.” It was demolished in 2007 and the lot has laid vacant for years.

The Columbus Theatre was a theatre located at 114 E. 125th Street between Park Avenue and Lexington Avenue. It was the second theatre built by theatre impresario Oscar Hammerstein I. The architects were J. B. McElfatrick & Sons.The Columbus Theatre originally sat 1,649 people and was a major venue for musical theatre, vaudeville, and minstrel shows in Upper Manhattan. The theatre also occasionally served as an opera house, and sometimes presented plays ranging from classic works by William Shakespeare to new plays written by Americans. It opened in October 1890. The theatre was sold to F. F. Proctor in 1899 and was then renamed Proctor's 125th Street Theatre. It was later re-titled Keith & Proctor's 125th Street Theatre about a year later when Proctor formed a partnership with Benjamin Franklin Keith. After that partnership fell apart in 1911, it was once again known as Proctor's 125th Street Theatre or simply Proctor's Theatre. It was purchased by RKO sometime in the 1930s, and operated as a move theatre entitled RKO Proctor's 125th Street Theatre until it closed in 1957.

Arthur F. Collins (1937 – October 9, 1965) was a 28-year-old man who was murdered in a New York City subway after defending two women being assaulted by an intoxicated man. Collins's wife soon obtained employment, but in order to work, she had to send their daughter to live with relatives in Europe. Less than two months after Collins's wife was widowed, public outcry resulted in New York City Mayor Wagner signing a "good Samaritan" bill into law. In August 1966, New York State Governor Nelson Rockefeller signed into law a bill that would provide state compensation to eligible crime victims. Rockefeller said this law was the result of the murder of Collins. This law transitioned to the formation of the New York State Office of Victims Services, an agency that provides compensation to all innocent victims of all crimes.

The 125th Street station is an express station with four tracks and two island platforms. It is the northernmost Manhattan station on the IRT Lexington Avenue Line of the New York City Subway. Located at Lexington Avenue and East 125th Street (also known as Dr. Martin Luther King, Jr. Boulevard) in East Harlem, it is served by the 4 and 6 trains at all times, the 5 train at all times except late nights, and the <6> train during weekdays in peak direction. This station was constructed as part of the Dual Contracts by the Interborough Rapid Transit Company and opened in 1918. A planned northern extension of the Second Avenue Subway would connect with this station and with the Metro-North Railroad's Harlem–125th Street station, located one block west.

The Caribbean Cultural Center African Diaspora Institute (CCCADI) is a nonprofit organization based in East Harlem in New York City that serves as an Afro-Caribbean center of culture and community for members of the African diaspora.

Henry J. Carter Specialty Hospital and Nursing Facility, also known as NYC Health + Hospitals/Carter is a long-term acute care hospital (LTACH) located in East Harlem, New York City that was opened in 2013 by the New York City Health and Hospitals corporation.

The 121st Street station was a local station on the demolished IRT Second Avenue Line in Manhattan, New York City. It had three tracks and two side platforms. The next stop to the north was 125th Street. The next stop to the south was 117th Street. The station closed on June 11, 1940.

The Harlem–125th Street station is a commuter rail stop serving the Metro-North Railroad's Hudson, Harlem, and New Haven Lines. It is located at East 125th Street and Park Avenue in East Harlem, Manhattan, New York City. The station also serves as an important transfer point between the Metro-North trains and the New York City Subway's IRT Lexington Avenue Line (4, ​5, ​6, and <6> trains) for access to the Upper East Side of Manhattan. It is the only station besides Grand Central Terminal that serves all three lines east of the Hudson River. Trains leave for Grand Central Terminal, as well as to the Bronx and the northern suburbs, regularly.

The Church of St. Paul is a Roman Catholic parish church in the Roman Catholic Archdiocese of New York, located in the East Harlem neighborhood of Manhattan, New York City. The sixth parish established in New York City, it was designated a New York City Landmark on June 28, 2016.

The 116th Street station was a local station on the demolished IRT Third Avenue Line in Manhattan, New York City. The outer tracks had two side platforms for local trains, and was built first. The center track was built as part of the Dual Contracts for express trains. This station closed on May 12, 1955, with the ending of all service on the Third Avenue El south of 149th Street.