Durham Hosiery Mills No. 2–Service Printing Company Building

Venable Tobacco Company Warehouse is a historic tobacco storage warehouse located at Durham, Durham County, North Carolina. It consists of three storage units: Unit 1 and Unit 2 were built in 1905 and Unit 3 in the 1910s. It is a two-story, brick structure and is an example of "slow burn" masonry and wood factory construction. The warehouse is located adjacent to the Venable Tobacco Company Prizery and Receiving Room, which collectively are the only structures that remain of a larger complex.It was listed on the National Register of Historic Places in 1985.

St. Joseph's African Methodist Episcopal Church is a historic African Methodist Episcopal church building located at Fayetteville Street and Durham Expressway in the Hayti District, now a neighborhood of Durham, Durham County, North Carolina. Started soon after the American Civil War by black workers, the Hayti District became a well-developed and self-sufficient black community, complete with a variety of businesses and services, including theatre, hospital and hotel.The church was built in 1891, by a congregation that had organized in 1869, brought together in meetings in a "brush arbor" organized by Edian Markham, a former slave and AME missionary. After building a couple of wooden structures, the congregation raised money for this brick church, including funds donated by white philanthropists.Edian Markham is buried in Geer Cemetery. It was added to the National Register of Historic Places in 1976.It is now used by the St. Joseph Historic Foundation as the Hayti Heritage Centre for cultural and community activities.

Venable Tobacco Company Prizery and Receiving Room is a historic tobacco prizery located at Durham, Durham County, North Carolina. The prizery was built about 1930, and is a three-story, brick building. The trapezoidal shaped, one-story, concrete block receiving room was added in 1952. It is an example of "slow burn" masonry and wood factory construction. The prizery is located adjacent to the Venable Tobacco Company Warehouse, which collectively are the only structures that remain of a larger complex.It was listed on the National Register of Historic Places in 2003.

The Confederate Soldiers Monument (popularly known as "The Boys Who Wore Gray") was a memorial to the soldiers from Durham County who fought for the Confederate States of America in the American Civil War. The statue was seriously damaged by protestors and removed from public view on August 14, 2017.

Durham Hosiery Mill is a historic textile mill complex located at Durham, Durham County, North Carolina. It includes seven contributing brick buildings in the complex. The original Durham Hosiery Mill was built in 1902, and consists of a four-story main building with a six-story Romanesque Revival style tower in front; engine, boiler, and heater houses attached at the rear, and a one-story dye house. The main building was expanded with a two-story annex in 1904, and a three-story annex in 1906. Other buildings include the triangular Annex No. 1 (1912) and a three-story brick finishing building. By 1910, the Durham Hosiery Mills Corporation was the largest manufacturer of cotton hosiery in the world. The mill was abandoned in 1922.It was listed on the National Register of Historic Places in 1978.

Erwin Cotton Mills Company Mill No. 1 Headquarters Building, also known as Erwin Square, is a historic textile mill complex located at Durham, Durham County, North Carolina. The mill was built in 1892, and is a two-story, 748 feet long, brick building. It features three square towers projecting from the east facade and by hundreds of large and closely spaced windows. The building exemplifies "slow burn" construction with its exterior load bearing brick walls and its heavy timber heart pine beams and columns. The headquarters building is a Late Victorian style brick building built in 1892 and enlarged in 1896 and 1905. Attached to the headquarters building is a warehouse. In 1983–1984, the complex was renovated as offices and apartments.It was listed on the National Register of Historic Places in 1984. It is located in the West Durham Historic District.

The Durham County Justice Center is a civic building in downtown Durham, North Carolina. The $120 million building opened to the public in February 2013. The building houses the Durham County Sheriff's Office, the Durham County District Attorney's Office, and has 20 courtrooms. The building is 318,533 square feet and was built to LEED Gold Standards. The Justice Center was built with sustainable materials and includes lawns on its roofs for insulation and to capture runoff. It is one of the tallest buildings in Durham and dominates the downtown skyline from NC 147.

The Durham Performing Arts Center (often called the DPAC) opened November 30, 2008 as the largest performing arts center in the Carolinas at a cost of $48 million. The DPAC hosts over 200 performances a year including touring Broadway productions, high-profile concert and comedy events, family shows and the American Dance Festival. Operated under the direction of Nederlander and Professional Facilities Management (PFM), DPAC has twice been listed as the #1 performing arts organization in the Triangle region by the Triangle Business Journal. Construction of the DPAC was part of a larger plan to redevelop downtown Durham by the Capitol Broadcasting Company, and includes other nearby properties such as the American Tobacco Historic District, the Durham Bulls Athletic Park, and the studios of the CBC-owned Fox 50 TV station. Listed three times in the top 50 in Pollstar magazine's worldwide theater attendance ranking, in 2011 DPAC was the #1 U.S. Theater in the listing with a capacity under 4,000 and #4 ranked Theater among all U.S. Theaters. On August 16, 2016, the venue surpassed 3 million visitors since its opening.

Downtown Durham Historic District is a national historic district located at Durham, Durham County, North Carolina. The district encompasses 97 contributing buildings and 1 contributing structure in the central business district of Durham. The buildings primarily date from the first four decades of the 20th century and include notable examples of Colonial Revival, Italianate, and Art Deco architecture. Notable buildings include the St. Philip's Episcopal Church (1907), Trinity Methodist Episcopal Church (1880-1881), First Baptist Church (1926-1927), Durham County Courthouse (1916), Durham Auditorium (Carolina Theatre, 1920s), Tempest Building (1894, 1905), National Guard Armory (1934-1937), United States Post Office (1934), Trust Building (1904), First National Bank Building (1913-1915), Mechanics and Farmers Bank (1921), Johnson Motor Company showroom (1927), Hill Building (1935), Snow Building (1933), and S. H. Kress store.It was listed on the National Register of Historic Places in 1977.On August 14, 2017 a 15-foot-high statue of an armed Confederate patriot was torn down in front of the 1916 Durham County Courthouse by demonstrators. The destruction of the statue followed the 2017 Unite the Right rally in Charlottesville, Virginia where one counter-demonstrator was killed.

Durham Bulls Athletic Park (DBAP, pronounced "d-bap") is a 10,000-seat ballpark in Durham, North Carolina, that is home to the Durham Bulls, the Triple-A affiliate of the Tampa Bay Rays of Major League Baseball. It is also home to the Duke Blue Devils and North Carolina Central Eagles college baseball teams. The $18.5-million park opened in 1995 as the successor to Durham Athletic Park.

The Old North Carolina Mutual Life Insurance Company Building, also known as the Mechanics and Farmers Bank Building, is an office building at 114-116 West Parrish Street in downtown Durham, North Carolina. It formerly served as the headquarters for the North Carolina Mutual Life Insurance Company, which was formerly one of the nation's largest companies founded and owned by African-Americans. The building was declared a National Historic Landmark in 1975.

One City Center is a 27-story mixed-use tower located at 110 Corcoran Street in Downtown Durham, North Carolina, in the United States. One City Center is the tallest building in downtown Durham, and the second tallest in Durham behind University Tower. Completed in 2018, One City Center is partially leased to Duke University and WeWork.