222 Second Street

Benu is a three-Michelin star restaurant located in the SoMa district of downtown San Francisco opened in 2010 by chef Corey Lee, the former Chef de cuisine at the French Laundry. Benu made the list of The World's 50 Best Restaurants in 2019.

140 New Montgomery Street, originally known as The Pacific Telephone & Telegraph Company Building, and, after 1984, as The Pacific Bell Building or The PacBell Building, in San Francisco's South of Market district, is an Art Deco mixed-use office tower located close to the St. Regis Museum Tower and the San Francisco Museum of Modern Art.The 26-floor building was designed to consolidate numerous smaller buildings and outdated offices into a modern headquarters for The Pacific Telephone & Telegraph Co., and as a result, was designated as the Pacific Telephone & Telegraph Co. Coast Division Offices by the company, though referred to colloquially as The Telephone Building. When it opened on May 30, 1925, The Pacific Telephone Building was San Francisco's first significant skyscraper development, and was the tallest building in San Francisco, until the Russ Building matched its height in 1927 at the time of its completion. The building was the first high-rise south of Market Street, and along with the Russ Building, remained the city's tallest until it was overtaken by 650 California Street in 1964. It was the first high rise located on the west coast to be occupied solely by a single tenant.AT&T sold the building in 2007, and as of 2013, Internet company Yelp is the main tenant.

Mourad is a Moroccan restaurant in San Francisco, California.

Temple is a nightclub first established in San Francisco, with an additional location in Denver. With a San Francisco location south of Market Street near the Salesforce Tower and Transbay Transit Center, the club was opened in 2007 by entrepreneur Paul Hemming. Temple has been notable for being among the highest-grossing nightclubs by revenue in the San Francisco Bay Area in the early 2010s.

Room 641A is a telecommunication interception facility operated by AT&T for the U.S. National Security Agency, as part of its warrantless surveillance program as authorized by the Patriot Act. The facility commenced operations in 2003 and its purpose was publicly revealed in 2006.

101 Second Street is an office tower located in the South of Market district in San Francisco, California on Mission Street. The 108 m (354 ft) building was completed in 2000 and has 26 floors with 388,000 sq ft (36,000 m2) for offices. It is known for its glass-clad, four-story atrium which functions as public space. Its art pavilion has included commissions by painter Charles Arnoldi and sculptor Larry Bell. On warm days, the building at street level is opened.

555 Mission Street is a 33 story, 147 m (482 ft) office tower in the South of Market area of San Francisco, California. Construction of the tower began in 2006 and the tower was finished on September 18, 2008. It was the tallest office building constructed in San Francisco in the 2000s, and is the 25th tallest building in San Francisco.The building is the part of a new generation of skyscrapers in San Francisco's downtown built on Mission Street since 2000, including The Paramount, the St. Regis Museum Tower, Millennium Tower, 101 Second Street, and JP MorganChase Building.

33 Tehama is a luxury residential apartment complex in the South of Market neighborhood in San Francisco, California. The building is 380 feet (120 m) tall, 35 stories, and contains 403 residential units. Groundbreaking was in mid-2015, and construction finished in 2018. The building is part of the San Francisco Transbay development area around the Transbay Transit Center site in the South of Market neighborhood. The building was developed by Hines and Invesco Real Estate. Lendlease was the general contractor. Due to repeated incidents of flooding on the 35th floor, the building was closed indefinitely to all tenants on June 3, 2022. It was initially not expected to reopen until early 2023; However, as of October 11, 2023 (over a year since the building was closed), the building still has not reopened to the public.

New Montgomery Street, formerly Montgomery Street South, begins at Market Street and terminates at Howard Street in the SOMA district of San Francisco, California.

W San Francisco is a 31-floor, 96 m (315 ft) highrise luxury boutique hotel in San Francisco, California located next to the San Francisco Museum of Modern Art and across from Moscone Center. The tower was constructed by Webcor Builders and opened in 1999. The building was the tallest concrete-framed structure in San Francisco until The Paramount was completed three years later. The hotel contains 401 rooms operated by W Hotel, which is under the same operator (Marriott International) as the nearby St. Regis Museum Tower.

535 Mission Street is an office skyscraper in the South of Market district of San Francisco, California, opened in November 2014, with 27 stories rising 378 ft (115 m) above street level. It is adjacent to the Transbay Transit Center site and located on the same block as 100 First Plaza, 555 Mission Street, and 101 Second Street.

DoorDash, Inc. is an American company that operates an online food ordering and food delivery platform. The company is based in San Francisco, California. It went public in December 2020 on NYSE and trades under the symbol DASH.With a 56% market share, DoorDash is the largest food delivery company in the United States. It also has a 60% market share in the convenience delivery category. As of December 31, 2020, the platform was used by 450,000 merchants, 20,000,000 consumers, and one million deliverers.DoorDash has been criticized and sued for withholding tips, reducing tip transparency, antitrust price manipulation, listing restaurants without permission, and allegedly misclassifying workers.