Walker's Mill and Walker's Bank

Along Delaware Route 141 there are a number of historic sites that trace the history of both the Du Pont family and the DuPont company. At the southwest end is DuPont’s Chestnut Run Plaza and at the northeastern end is the Alfred I. duPont Hospital for Children. Between are a number of sites on the National Register of Historic Places. The historic locations include equal portion of the history of the American chemical industry, the role of the DuPont family - their estates and gardens - and the philanthropy of a distinguished American family.

Breck's Mill Area, also known as Breck's Mill Area-Henry Clay Village Historic District, is a national historic district located along Brandywine Creek in unincorporated New Castle County, Delaware, near Wilmington. It encompasses 56 contributing buildings, five contributing sites, and three contributing structures. The district encompasses The Mill, The Workers' houses, and The Mill Owner's Home. Breck's Mill was built in 1813 and rebuilt in 1846 after a fire. It is a three-story, stone structure measuring 55 feet by 43 feet. It features a stone bell tower with a top floor of brick. The Henry Clay Village area includes small single or double workers' houses, the Charles I. du Pont house (1823), Ernest du Pont house (1916), William F. Raskob house , Hagee's Tavern, Greenhill Presbyterian Church, and the original building for the Alexis I. duPont High School (1893). "Rokeby" was built in 1836, and is a two-story, rectangular dwelling in a late Federal style. It measures 55 feet wide and 26 feet, 4 inches, deep, and features a two-story portico overlooking the Brandywine. It was built by mill owner William Breck for his new wife Gabrielle du Pont and is thought to be modeled on Louviers. The mill closed in 1854. It has been a recreational center off and on since 1890. Breck's Mill houses the post office for Montchanin, Delaware, Somerville Manning Gallery, and André Harvey's sculpture studio. It was added to the National Register of Historic Places in 1971 and amended in 1988.

Tower Hill School is a private college preparatory school in Wilmington, Delaware, offering instruction for pre-school through 12th grade.

The DuPont Experimental Station is the main research and development site of DuPont and Chemours, located along Delaware Route 141. The site map is shown in the Figure and the buildings are numbered. The map is not fixed in time in that not all of the building shown existed in the same time frame. Some were demolished before other were built. The site was initiated along the banks of the Brandywine River so the lowest numbers are in the lower left of the map. Expansion has taken place toward the upper right, slowly displacing the DuPont Country Club, so those are the more modern buildings and the more recent history of the site. Each of the business units of the company have had research facilities at the Experimental Station, so the inventions listed below reflect the nature of the research carried out in each building.

The DuPont Experimental Station is the largest research and development facility of DuPont. Located on the banks of the Brandywine Creek in Wilmington, Delaware, it is home to some of the most important discoveries of the modern chemical industry.

Rockford Park is a historic public park located in a residential area of Wilmington, New Castle County, Delaware. It is characterized by a large, grassy meadow which slopes gently upward to a large knoll overlooking the Brandywine River. It was added to the National Register of Historic Places in 1978. The park is a unit of Delaware's Wilmington State Parks.

Brandywine Manufacturers Sunday School, also known as Sunday School and Hagley Office, is a historic Sunday school building located near Wilmington, New Castle County, Delaware. It was built in 1817, and is a one-story, rectangular stone building. It measures 31 feet by 65 feet and features an Ionic order columned portico and school bell tower. Also on the property is a contributing spring house. It was built for workers, old and young, to learn the basics of reading, writing, and "ciphering," and remained in use as a school until 1851. From 1902 to 1921, it was the Hagley Yard office of the E. I. du Pont de Nemours Company. It was then converted to a private dwelling.It was added to the National Register of Historic Places in 1972.

The Jacob Broom House, also known historically as Hagley, is a historic house on Christchurch Road near Montchanin, Delaware. It was built in 1795 by Jacob Broom, one of the Delaware signers of the United States Constitution. The house was purchased in 1802 by Éleuthère Irénée du Pont, progenitor of the prominent Du Pont family and founder of the DuPont chemical concern, who established the Eleutherian Mills below the house on the banks of Brandywine Creek. The house, which remains in the hands of Du Pont descendants, was declared a National Historic Landmark in 1974, for its association with Broom.

Gibraltar (previously known as the Hugh Rodney Sharp Mansion), located at 2505 Pennsylvania Avenue in Wilmington, Delaware, is a country estate home dating from c. 1844 that is listed on the National Register of Historic Places. It takes its name from the Rock of Gibraltar, alluding to the high rocky outcrop on which the house was built. It is located just inside Wilmington's city limits and originally stood at the center of a much larger estate which has over time been reduced to the present area of about a city block in size. The house was originally built by John Rodney Brincklé and inherited by his brother's wife and children, before being bought in 1909 by Hugh Rodney Sharp, who was linked to the Du Pont family through marriage and work. Sharp expanded and remodeled the house, as well as commissioning the pioneering female landscape designer Marian Cruger Coffin to lay out the gardens.The gardens are now owned by a local preservation trust which acquired it in the 1990s after it was threatened with demolition and redevelopment. They have since been restored and opened to the public. The estate was listed in the National Register of Historic Places in 1998 in recognition of its importance as a well-preserved example of the Country Place era of art and design. The mansion, currently owned by a local developer, has not been occupied for many years and its condition has significantly deteriorated.

St. Joseph on the Brandywine, originally Saint Joseph's Church until St. Joseph's Church- Wilmington was built in 1947, is a parish of the Roman Catholic Church in Greenville, New Castle County, Delaware, in the Diocese of Wilmington. It is noted for its historic parish church complex and national historic district located on Old Church Road. Since 2002 its old convent building has housed the Diocesan Archives of Wilmington, with records spanning the last two centuries of church activity in Delaware. It is also the home parish of the 46th President of the United States, Joe Biden.

From 1802 to 1921, Eleutherian Mills was a gunpowder mill site used for the manufacture of explosives founded by Eleuthère Irénée du Pont, which grew into the DuPont company. The name also refers to the house on the hill above the mills, which was the first du Pont family home in America. In 1957 the site became an outdoor museum when the Hagley Museum and Library was founded. The site was declared a National Historic Landmark in 1966.

The Hagley Museum and Library is a nonprofit educational institution in unincorporated New Castle County, Delaware, near Wilmington. Covering more than 235 acres (95 ha) along the banks of the Brandywine Creek, the museum and grounds include the first du Pont family home and garden in the United States, the powder yards, and a 19th-century machine shop. On the hillside below the mansion lies a Renaissance Revival garden, with terraces and statuary, created in the 1920s by Louise Evelina du Pont Crowninshield (1877–1958).