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The Queensboro Bridge, officially named the Ed Koch Queensboro Bridge, is a cantilever bridge over the East River in New York City. Completed in 1909, it connects the neighborhood of Long Island City in the borough of Queens with the Upper East Side in Manhattan, passing over Roosevelt Island. The bridge is also known as the 59th Street Bridge because its Manhattan end is located between 59th and 60th streets. The Queensboro Bridge carries New York State Route 25 (NY 25), which terminates at the bridge's western end in Manhattan, and also once carried NY 24 and NY 25A. The western leg of the Queensboro Bridge is flanked on its northern side by the freestanding Roosevelt Island Tramway. The bridge was, for a long time, simply called the Queensboro Bridge, but in March 2011, the bridge was officially renamed in honor of former New York City mayor Ed Koch. The Queensboro Bridge is the northernmost of four toll-free vehicular bridges connecting Manhattan Island to Long Island, along with the Williamsburg, Manhattan, and Brooklyn bridges to the south. It is the first entry point into Manhattan in the course of the New York City Marathon and the last exit point out of Manhattan in the Five Boro Bike Tour.

The Roosevelt Island Tramway is an aerial tramway in New York City that spans the East River and connects Roosevelt Island to the Upper East Side of Manhattan. The tramway is the first commuter aerial tramway in North America, having opened in 1976. Since then, over 26 million passengers have ridden the tram. The tram consists of two cars that run back and forth on two parallel tracks. It is one of the few forms of mass transit in New York City not run by the Metropolitan Transportation Authority, although it uses the MTA's MetroCard and has free transfers to the subway system. The tram is operated by Leitner-Poma on behalf of the Roosevelt Island Operating Corporation of the State of New York, a state public benefit corporation created in 1984 to run services on the island.

City Hospital (also known as Island Hospital or Charity Hospital) was an historic hospital on Roosevelt Island, Manhattan in New York City.

Strecker Memorial Laboratory is a historic building located in Southpoint Park on Roosevelt Island in New York City. Built in 1892 to serve as a laboratory for City Hospital, it was "the first institution in the nation for pathological and bacteriological research". The project was funded by the Strecker family. The building was designed by architects Frederick Clarke Withers and Walter Dickson in the Romanesque Revival style with large arched windows to provide plenty of natural lighting and ventilation. On the first floor were an autopsy room and an office, while the floor above housed laboratories where specimens were examined. The cellar was used as a mortuary and for storage. Administrative support was provided by the nearby City Hospital. An additional storey was later built, providing room for the examination of histological samples, a scientific library and a pathology museum.In 1907, the Russell Sage Institute of Pathology took over the running of the lab. In time, this became associated with the Rockefeller University, and work continued at the laboratory until it closed in the 1950s, after which it fell into disrepair.In 1972, it was added to the National Register of Historic Places, and in 1976 it was designated a New York City landmark. The Metropolitan Transportation Authority decided to use the structure to house a power conversion substation for the subway trains that run through the 53rd Street Tunnel underneath Roosevelt Island. The city faithfully restored the building, and the substation has been active since 2000.

East 60th Street Heliport (IATA: JRE, ICAO: KJRE, FAA LID: 6N4) was a public heliport on the Upper East Side of Manhattan located between the East River and the FDR Drive. Also known as the Pan Am Metroport, the city-owned facility was originally operated by Pan American World Airways. The heliport opened in 1968 and closed in 1998.

One Sutton Place South is a 14-story, 42-unit cooperative apartment house in the East Midtown neighborhood of Manhattan, New York City, overlooking the East River on Sutton Place between 56th and 57th Streets. One Sutton Place South contains the residences of diplomats, titans of industry, and media executives.

The 63rd Street Tunnel is a double-deck subway and railroad tunnel under the East River between the boroughs of Manhattan and Queens in New York City. Opened in 1989, it is the newest of the East River tunnels, as well as the newest rail river crossing in the New York metropolitan area. The upper level of the 63rd Street Tunnel carries the IND 63rd Street Line of the New York City Subway. As of 2021, the tunnel's lower level has never been used for passenger service, but is expected to carry Long Island Rail Road (LIRR) trains to a new train terminal under Grand Central Terminal, following the completion of the East Side Access project, scheduled for 2022. Construction of the 63rd Street Tunnel began in 1969, and the tunnel was holed through beneath Roosevelt Island in 1972. Completion of the tunnel and its connections was delayed by the 1975 New York City fiscal crisis and the upper level was not opened until 1989, twenty years after construction started. The lower level was not opened at that time because of the cancellation of the LIRR route to Manhattan. The tunnel was initially referred to as the "tunnel to nowhere" because its Queens end did not connect to any other subway line until 2001. Construction on the East Side Access project, which will incorporate the lower level, started in 2006. During construction, the lower level is being used to move materials between the work sites in Manhattan and staging areas in Queens.

The Roosevelt Island station is a station on the IND 63rd Street Line of the New York City Subway. Located in Manhattan on Roosevelt Island in the East River, it is served by the F train at all times and the train during rush hours in the reverse peak direction. The Roosevelt Island station was first proposed in 1965, when the New York City Transit Authority (NYCTA) announced that it would build a subway station to encourage transit-oriented development on Roosevelt Island. The station and the rest of the 63rd Street Line were built as part of the Program for Action, a wide-ranging subway expansion program, starting in the late 1960s. When construction of the line was delayed, the Roosevelt Island Tram was built in 1973. The Roosevelt Island Operating Corporation was formed in 1984 to develop the island, but was not successful until October 1989 when the subway station opened along with the rest of the 63rd Street Line. The opening encouraged the development of the island, which has made the station busier. Until December 2001, this was the second-to-last stop of the line, which terminated one stop east at 21st Street–Queensbridge. In 2001, the 63rd Street Tunnel Connection opened, allowing trains from the IND Queens Boulevard Line to use the line. Since the opening of the connection, the line has been served by F trains, and the subway then became the second means for direct travel between the island and Queens, supplementing the buses that had been operating over the Roosevelt Island Bridge. The station is one of the system's deepest, at 100 feet (30 m) below ground, because the line passes under the West and East Channels of the East River at either end of the station.

The Payne Whitney Psychiatric Clinic (PWC) was a hospital in the Upper East Side of Manhattan, New York City, which was founded by an endowment bestowed by Payne Whitney (March 20, 1876 – May 25, 1927) upon his death. Whitney was an American businessman and member of the influential Whitney family. An eight-story free-standing hospital was constructed, and was affiliated with Cornell University's medical school, now called Weill Cornell Medicine, and with New York Hospital, now New York–Presbyterian Hospital (NYP), before its opening. Payne Whitney was a large donor to the Hospital and Medical College, and it has been an issue of long speculation why he chose a psychiatric building to be his primary naming opportunity at New York-Cornell. The Payne Whitney building itself was torn down in the early 1990s to make way for an expansion of the New York-Presbyterian Hospital over the FDR Drive. Since that time, all clinical and research services at the two primary Cornell psychiatric campuses—in Manhattan and in White Plains, New York—have been named after Payne Whitney. The clinic also has an outpatient and Continuing Day Treatment Program in an off-campus building at East 61st Street and York Avenue in the Upper East Side.

The Bentley Hotel is a hotel in Manhattan's Upper East Side, in the U.S. state of New York.

The Smallpox Hospital, sometimes referred to as the Renwick Smallpox Hospital and later the Maternity and Charity Hospital Training School, was a hospital located on Roosevelt Island in Manhattan, New York City. Originally designed by architect James Renwick Jr., the 100-bed hospital opened in 1856, when the area was known as Blackwell's Island.A century after it opened, the hospital was closed, and the building eventually fell into disrepair. It was listed on the National Register of Historic Places in 1972 and designated a New York City Landmark four years later, the only ruin in the city with that designation. After the completion of an ongoing $4.5 million stabilization project, the Smallpox Hospital ruins will be open to the public.

Sutton 58 (also known as 3 Sutton Place) is a residential skyscraper in the Sutton Place neighborhood of Midtown East, Manhattan in New York City.