Roosevelt Island Tramway

The Queensboro Bridge, officially named the Ed Koch Queensboro Bridge, is a cantilever bridge over the East River in New York City. Completed in 1909, it connects the neighborhood of Long Island City in the borough of Queens with the Upper East Side in Manhattan, passing over Roosevelt Island. The bridge is also known as the 59th Street Bridge because its Manhattan end is located between 59th and 60th streets. The Queensboro Bridge carries New York State Route 25 (NY 25), which terminates at the bridge's western end in Manhattan, and also once carried NY 24 and NY 25A. The western leg of the Queensboro Bridge is flanked on its northern side by the freestanding Roosevelt Island Tramway. The bridge was, for a long time, simply called the Queensboro Bridge, but in March 2011, the bridge was officially renamed in honor of former New York City mayor Ed Koch. The Queensboro Bridge is the northernmost of four toll-free vehicular bridges connecting Manhattan Island to Long Island, along with the Williamsburg, Manhattan, and Brooklyn bridges to the south. It is the first entry point into Manhattan in the course of the New York City Marathon and the last exit point out of Manhattan in the Five Boro Bike Tour.

Cornell Tech is a technology, business, law, and design campus of Cornell University located on Roosevelt Island in Manhattan, New York City. It includes the Jacobs Technion-Cornell Institute, a joint academic venture between Cornell and the Technion – Israel Institute of Technology. Cornell Tech arose from an economic development initiative of Michael Bloomberg's mayoral administration in 2008. The initiative sought to attract another engineering school to the city in the hope that it would produce entrepreneurial engineers who would in turn start job-creating companies. Seven bids were submitted for the competition, with the administration ultimately selecting Cornell/Technion's bid. As proposed, Cornell Tech would create 28,000 jobs, including 8,000 for academic staff. It would also be able to create 600 companies, leading to $23 billion in economic benefits and an additional $1.4 billion in taxes, during its first three decades of operation. Cornell Tech began operations in 2012 at a temporary site, the New York City offices of Google at 111 Eighth Avenue in the Chelsea neighborhood of Manhattan, while a permanent campus was under construction. The Roosevelt Island campus's 5-acre (2.0 ha) first phase opened on September 13, 2017. By 2037, the full campus is expected to span 12 acres (4.9 ha).

The 63rd Street Tunnel is a double-deck subway and railroad tunnel under the East River between the boroughs of Manhattan and Queens in New York City. Opened in 1989, it is the newest of the East River tunnels, as well as the newest rail river crossing in the New York metropolitan area. The upper level of the 63rd Street Tunnel carries the IND 63rd Street Line of the New York City Subway. As of 2021, the tunnel's lower level has never been used for passenger service, but is expected to carry Long Island Rail Road (LIRR) trains to a new train terminal under Grand Central Terminal, following the completion of the East Side Access project, scheduled for 2022. Construction of the 63rd Street Tunnel began in 1969, and the tunnel was holed through beneath Roosevelt Island in 1972. Completion of the tunnel and its connections was delayed by the 1975 New York City fiscal crisis and the upper level was not opened until 1989, twenty years after construction started. The lower level was not opened at that time because of the cancellation of the LIRR route to Manhattan. The tunnel was initially referred to as the "tunnel to nowhere" because its Queens end did not connect to any other subway line until 2001. Construction on the East Side Access project, which will incorporate the lower level, started in 2006. During construction, the lower level is being used to move materials between the work sites in Manhattan and staging areas in Queens.

The Roosevelt Island station is a station on the IND 63rd Street Line of the New York City Subway. Located in Manhattan on Roosevelt Island in the East River, it is served by the F train at all times and the train during rush hours in the reverse peak direction. The Roosevelt Island station was first proposed in 1965, when the New York City Transit Authority (NYCTA) announced that it would build a subway station to encourage transit-oriented development on Roosevelt Island. The station and the rest of the 63rd Street Line were built as part of the Program for Action, a wide-ranging subway expansion program, starting in the late 1960s. When construction of the line was delayed, the Roosevelt Island Tram was built in 1973. The Roosevelt Island Operating Corporation was formed in 1984 to develop the island, but was not successful until October 1989 when the subway station opened along with the rest of the 63rd Street Line. The opening encouraged the development of the island, which has made the station busier. Until December 2001, this was the second-to-last stop of the line, which terminated one stop east at 21st Street–Queensbridge. In 2001, the 63rd Street Tunnel Connection opened, allowing trains from the IND Queens Boulevard Line to use the line. Since the opening of the connection, the line has been served by F trains, and the subway then became the second means for direct travel between the island and Queens, supplementing the buses that had been operating over the Roosevelt Island Bridge. The station is one of the system's deepest, at 100 feet (30 m) below ground, because the line passes under the West and East Channels of the East River at either end of the station.

East 60th Street Heliport (IATA: JRE, ICAO: KJRE, FAA LID: 6N4) was a public heliport on the Upper East Side of Manhattan located between the East River and the FDR Drive. Also known as the Pan Am Metroport, the city-owned facility was originally operated by Pan American World Airways. The heliport opened in 1968 and closed in 1998.

The Bentley Hotel is a hotel in Manhattan's Upper East Side, in the U.S. state of New York.

The Payne Whitney Psychiatric Clinic (PWC) was a hospital in the Upper East Side of Manhattan, New York City, which was founded by an endowment bestowed by Payne Whitney (March 20, 1876 – May 25, 1927) upon his death. Whitney was an American businessman and member of the influential Whitney family. An eight-story free-standing hospital was constructed, and was affiliated with Cornell University's medical school, now called Weill Cornell Medicine, and with New York Hospital, now New York–Presbyterian Hospital (NYP), before its opening. Payne Whitney was a large donor to the Hospital and Medical College, and it has been an issue of long speculation why he chose a psychiatric building to be his primary naming opportunity at New York-Cornell. The Payne Whitney building itself was torn down in the early 1990s to make way for an expansion of the New York-Presbyterian Hospital over the FDR Drive. Since that time, all clinical and research services at the two primary Cornell psychiatric campuses—in Manhattan and in White Plains, New York—have been named after Payne Whitney. The clinic also has an outpatient and Continuing Day Treatment Program in an off-campus building at East 61st Street and York Avenue in the Upper East Side.

The Nurses Residence is a building on the Rockefeller University campus in Manhattan, New York City.

One Sutton Place South is a 14-story, 42-unit cooperative apartment house in the East Midtown neighborhood of Manhattan, New York City, overlooking the East River on Sutton Place between 56th and 57th Streets. One Sutton Place South contains the residences of diplomats, titans of industry, and media executives.

Welch Hall is a building on the Rockefeller University campus in Manhattan, New York City.

Rockefeller Demonstration Hospital, also known as Rockefeller base hospital and United States Army Auxiliary Hospital No. 1 was a World War One era field hospital designed, located and operated by Rockefeller Institute for Medical Research in Manhattan, New York City.

The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classified among "R2: Doctoral Universities – High research activity." Rockefeller is the oldest biomedical research institute in the United States. In 2018, the faculty included 82 tenured and tenure-track members, including 37 members of the National Academy of Sciences, 17 members of the National Academy of Medicine, seven Lasker Award recipients, and five Nobel laureates. As of March 2022, a total of 26 Nobel laureates have been affiliated with Rockefeller University.The university is located on the Upper East Side of Manhattan, between 63rd and 68th streets on York Avenue. Richard P. Lifton became the university's eleventh president on September 1, 2016. The Rockefeller University Press publishes the Journal of Experimental Medicine, the Journal of Cell Biology, and The Journal of General Physiology.