Museo Castillo Serrallés

Castillo Serrallés (English: Serralles Castle) is a mansion located in the city of Ponce, Puerto Rico, overlooking the downtown area (Ponce Pueblo). It was built during the 1930s for Juan Eugenio Serrallés, son of businessman Juan Serrallés, founder of Destilería Serrallés. The structure sits on a 2.5-acre (1.0 ha) exceedingly manicured property. Nowadays, the structure functions as a museum, Museo Castillo Serrallés, with information about the sugar cane and rum industries and its impact in the economy of Puerto Rico. It is also increasingly used as a venue for social activities, including destination weddings. The property was listed in the National Register of Historic Places in 1980. In 1996, the structure was featured in the American TV series America's Castles.

Cruceta del Vigía (English: The Watchman Cross) is a 100 feet (30 m) tall cross located atop Cerro del Vigía in Ponce, Puerto Rico, across from Museo Castillo Serrallés. It houses a tourist center at its base, a ten-story vertical tower, and a horizontal sky bridge that has panoramic views of the city of Ponce and the Caribbean Sea. Visitors can reach the skybridge via glass elevators or a staircase. Made of reinforced concrete, the cross has withstood various natural disasters, including three major hurricanes. The arms of the cross measure 70 feet. It was inaugurated in 1984.One of many landmarks of the city of Ponce, the cross is owned by the Municipality of Ponce and is currently operated by the "Patronato de Ponce", a non-profit organization dedicated to preserving the city's cultural heritage. It is visited annually by some 100,000 tourists.

Cerro del Vigía is a hill in the municipality of Ponce, Puerto Rico, located just north of the city of Ponce. A tourist destination, it is home to Museo Castillo Serrallés, Cruceta del Vigía, and the former Hotel Ponce Intercontinental. The 456-foot high hill sits at the foothills of the Cordillera Central and is located in Barrio Portugués Urbano. The hill is home to several well-to-do mansions of which the best known is Castillo Serrallés, now a Museum.

The Hotel Ponce Intercontinental (also known as "El Ponce") is an abandoned hotel with a still existing structure at Cerro del Vigía in Ponce, Puerto Rico. The structure is considered a historic landmark and a national icon in the city of Ponce and Puerto Rico. The property is currently owned by Misla Hospitality Group, a family of local Ponce investors who bought it from CBC Development. Its architecture is classical modern. When it opened, in 1960, it became the first modern hotel in the city.

The Panteón Nacional Román Baldorioty de Castro (English: Román Baldorioty de Castro National Pantheon) is a tract of land in Barrio Segundo of the city of Ponce, Puerto Rico, originally designed as the city's cemetery, but later converted into what has come to be a famous burial place. Established in 1842, it is Puerto Rico's first (and only) national pantheon. It is the only cemetery dedicated as a museum in Puerto Rico and the Caribbean. Prior to being dedicated as a Panteón Nacional, it was known as Cementerio Viejo or as Cementerio Antiguo de Ponce, and is listed under that name on the U.S. National Register of Historic Places. The Pantheon is named after Román Baldorioty de Castro, a prolific Puerto Rican politician, and firm believer of Puerto Rican autonomy and independence. His remains are located here. The Pantheon also houses a small museum about the history of autonomism in the Island, and it is currently used both as a park and a venue for the expression of culture and the arts. It is called the Museo del Autonomismo Puertorriqueño. Prior to being turned into a National Pantheon in 1991, it was known as Antiguo Cementerio de Ponce (Ponce's Old Cemetery), to differentiate it from the newer (though now also over 100 years old) Cementerio Civil de Ponce (Ponce Civil Cemetery). Built in 1842, after the design of Antonio Torruella, the cemetery was enlarged in 1864, following the design of Nieto Blajol Iglesia. It closed in 1918.

Segundo (Barrio Segundo) is one of the 31 barrios of the municipality of Ponce, Puerto Rico. Along with Primero, Tercero, Cuarto, Quinto, and Sexto, Segundo is one of the municipality's six core urban barrios. It was organized in 1878. Barrio Segundo has 3 subbarrios: Baldority de Castro (or just "Baldorioty"), Clausells, and Reparada.

Albergue Caritativo Tricoche or Hospital Tricoche (English: Tricoche Charitable Shelter or Tricoche Hospital) is a historic building located on Calle Tricoche street in Ponce, Puerto Rico, in the city's historic district. It was designed by the Spanish Royal Corps of Engineers. The architecture consists of 19th-century civil architecture. When built in 1878, "it held the top spot among public building in Puerto Rico," based on its size and beauty.The hospital was named after Valentin Tricoche, a 19th-century philanthropist and land owner in Ponce with lands on the western bank of Rio Bucana which included lands with a stone mine. Valentin Tricoche left moneys in his will for the construction of the hospital. Construction started on 30 May 1873, it was delivered to the Municipal government by the Spanish Royal Corps of Engineers in September 1876, and opened to the public on 11 December 1878. The structure was built articulated in the Classical revival style. By 1885, the hospital was expanded with an annex which was named "Hospital Civil de Ponce", to differentiate it from the original hospital built with funds from Valentin Tricoche.The historic structure was listed on the U.S. National Register of Historic Places on 14 May 1987.

The Antiguo Hospital Militar Español de Ponce (English: Old Spanish Military Hospital in Ponce) is a historic building in Ponce, Puerto Rico, in the city's historic district. The building dates from 1896 or 1897. It was designed by the Spanish Royal Corps of Engineers. The architecture consists of 19th Neoclassical architecture style. The building is of architectural significance since it is the only one-story building of this style remaining in the city of Ponce and one of the best examples on the Island. Completed in 1897, the year before the Spanish–American War of 1898, this building was the last major construction undergone by the Spanish Government in the Americas. From 1905 to the mid 1970s the structure served as the Asilo de Ciegos de Ponce (Ponce Blind Asylum). As of 2020 the building sits abandoned.

The Acueducto de Ponce (Ponce Aqueduct), formally Acueducto Alfonso XII, is the name of a historic 2.5-mile gravity-based water supply system in the city of Ponce, Puerto Rico. It was designed in 1875 by Timoteo Luberza and built the following years. This aqueduct was the first modern water distribution system built in Puerto Rico. The Aqueduct (or, more precisely, its conduit channel at its highest elevation point in Barrio Mameyes) was known as El Puente de los Suicidios (Bridge of the suicides). It was declared a National Historic Monument on 17 June 2015.

Terminal de Transportación Pública Carlos Garay (Carlos Garay Public Transportation Terminal), formerly, Terminal de Carros Públicos Carlos Garay (Carlos Garay Carros Públicos Terminal), is a public transportation terminal for shared ride passengers and SITRAS bus system in Ponce, Puerto Rico. It is located on the block bounded by Calle Vives, Calle Unión, Calle Victoria and Calle Mendez Vigo, in the Ponce Historic Zone, two blocks northwest of the main city square, Plaza Las Delicias. It opened in 1987. On a typical weekday, approximately 500 passengers on about 40 buses and shared-ride vehicles use the station. The building is an example of 1960s urban renewal. When at its peak, the Carlos Garay terminal accommodates over 100 públicos.

The Centro Ponceño de Autismo (English: Ponce Autism Center), or CEPA, is the only center specialized in the diagnosis and treatment of autism in Puerto Rico. It is a non-profit organization. The center leads progressive research studies and medical training while providing comprehensive, personalized care to children and adults with Autism Spectrum Disorders (ASD), including Asperger's Disorder and PDD NOS. Working together with families, the Centro Ponceño de Autismo aims to identify the causes of autism and advance effective treatments. In 2011, it was reported that the Center cared for 179 patients.

The Luis A. Ferré United States Courthouse and Post Office Building (aka, Correo de la Calle Atocha) in Ponce, Puerto Rico, previously known as the U.S. Post Office and Court House, is a historic post office and courthouse facility of the United States, housing operations of the United States District Court for the District of Puerto Rico. It was the first U.S. postal office established in Puerto Rico.The building was designed by the Office of the Supervising Architect under James A. Wetmore and was built in 1933. In 2003 it was renamed the Luis A. Ferré United States Courthouse and Post Office Building by an Act of the U.S. Congress. The building sits at the same location where the Ponce Trainway depot used to be. The building is located on the southwest corner of Atocha and Guadalupe streets, facing Calle Atocha. The building suffered a major fire on 5 March 2018 which totally disabled and halted all postal activity processing activities at the facility.