Hotel Ponce Intercontinental

Cruceta del Vigía (English: The Watchman Cross) is a 100 feet (30 m) tall cross located atop Cerro del Vigía in Ponce, Puerto Rico, across from Museo Castillo Serrallés. It houses a tourist center at its base, a ten-story vertical tower, and a horizontal sky bridge that has panoramic views of the city of Ponce and the Caribbean Sea. Visitors can reach the skybridge via glass elevators or a staircase. Made of reinforced concrete, the cross has withstood various natural disasters, including three major hurricanes. The arms of the cross measure 70 feet. It was inaugurated in 1984.One of many landmarks of the city of Ponce, the cross is owned by the Municipality of Ponce and is currently operated by the "Patronato de Ponce", a non-profit organization dedicated to preserving the city's cultural heritage. It is visited annually by some 100,000 tourists.

Cerro del Vigía is a hill in the municipality of Ponce, Puerto Rico, located just north of the city of Ponce. A tourist destination, it is home to Museo Castillo Serrallés, Cruceta del Vigía, and the former Hotel Ponce Intercontinental. The 456-foot high hill sits at the foothills of the Cordillera Central and is located in Barrio Portugués Urbano. The hill is home to several well-to-do mansions of which the best known is Castillo Serrallés, now a Museum.

Museo Castillo Serrallés (English: Serrallés Castle Museum), a.k.a. Museo de la Caña y el Ron (English: Sugar Cane and Rum Museum), is an agricultural museum in the city of Ponce, Puerto Rico, that showcases the history of sugar cane, its derivative rum industry, and their impact in the economy of Puerto Rico. The most notorious feature of the museum is the building it occupies. The building is a large four-story structure built in the 1930s for the owner of Ponce's Destileria Serralles, one of Puerto Rico's largest rum distilleries. The distillery was once also home to Puerto Rico's largest sugar-factory called Central Mercedita, producers of the Snow White sugar brand. The building, known as Castillo Serrallés, was designed by Pedro Adolfo de Castro in 1930 in the Spanish Colonial Revival style.The museum sits on a 2.5-acre lot and opened on 20 February 1991. Visitors can tour the refurbished home, which has been furnished to appear as it did in the 1930s. There is also a temporary exhibit area for local artists. The Serrallés Castle is now part of a large complex that includes the Cruceta El Vigía, a Japanese Garden, and a butterfly garden (Mariposario). By September 2010, the museum was receiving around 100,000 visitors per year.

Castillo Serrallés (English: Serralles Castle) is a mansion located in the city of Ponce, Puerto Rico, overlooking the downtown area (Ponce Pueblo). It was built during the 1930s for Juan Eugenio Serrallés, son of businessman Juan Serrallés, founder of Destilería Serrallés. The structure sits on a 2.5-acre (1.0 ha) exceedingly manicured property. Nowadays, the structure functions as a museum, Museo Castillo Serrallés, with information about the sugar cane and rum industries and its impact in the economy of Puerto Rico. It is also increasingly used as a venue for social activities, including destination weddings. The property was listed in the National Register of Historic Places in 1980. In 1996, the structure was featured in the American TV series America's Castles.

Portugués Urbano is one of the 31 barrios in the municipality of Ponce, Puerto Rico. Along with Canas Urbano, Machuelo Abajo, Magueyes Urbano, and San Antón, Portugués Urbano is one of the municipality's five originally rural barrios that are now also part of the urban zone of the city of Ponce. It was founded in 1953.

The Panteón Nacional Román Baldorioty de Castro (English: Román Baldorioty de Castro National Pantheon) is a tract of land in Barrio Segundo of the city of Ponce, Puerto Rico, originally designed as the city's cemetery, but later converted into what has come to be a famous burial place. Established in 1842, it is Puerto Rico's first (and only) national pantheon. It is the only cemetery dedicated as a museum in Puerto Rico and the Caribbean. Prior to being dedicated as a Panteón Nacional, it was known as Cementerio Viejo or as Cementerio Antiguo de Ponce, and is listed under that name on the U.S. National Register of Historic Places. The Pantheon is named after Román Baldorioty de Castro, a prolific Puerto Rican politician, and firm believer of Puerto Rican autonomy and independence. His remains are located here. The Pantheon also houses a small museum about the history of autonomism in the Island, and it is currently used both as a park and a venue for the expression of culture and the arts. It is called the Museo del Autonomismo Puertorriqueño. Prior to being turned into a National Pantheon in 1991, it was known as Antiguo Cementerio de Ponce (Ponce's Old Cemetery), to differentiate it from the newer (though now also over 100 years old) Cementerio Civil de Ponce (Ponce Civil Cemetery). Built in 1842, after the design of Antonio Torruella, the cemetery was enlarged in 1864, following the design of Nieto Blajol Iglesia. It closed in 1918.

The Acueducto de Ponce (Ponce Aqueduct), formally Acueducto Alfonso XII, is the name of a historic 2.5-mile gravity-based water supply system in the city of Ponce, Puerto Rico. It was designed in 1875 by Timoteo Luberza and built the following years. This aqueduct was the first modern water distribution system built in Puerto Rico. The Aqueduct (or, more precisely, its conduit channel at its highest elevation point in Barrio Mameyes) was known as El Puente de los Suicidios (Bridge of the suicides). It was declared a National Historic Monument on 17 June 2015.

The Antiguo Hospital Militar Español de Ponce (English: Old Spanish Military Hospital in Ponce) is a historic building in Ponce, Puerto Rico, in the city's historic district. The building dates from 1896 or 1897. It was designed by the Spanish Royal Corps of Engineers. The architecture consists of 19th Neoclassical architecture style. The building is of architectural significance since it is the only one-story building of this style remaining in the city of Ponce and one of the best examples on the Island. Completed in 1897, the year before the Spanish–American War of 1898, this building was the last major construction undergone by the Spanish Government in the Americas. From 1905 to the mid 1970s the structure served as the Asilo de Ciegos de Ponce (Ponce Blind Asylum). As of 2020 the building sits abandoned.

Segundo (Barrio Segundo) is one of the 31 barrios of the municipality of Ponce, Puerto Rico. Along with Primero, Tercero, Cuarto, Quinto, and Sexto, Segundo is one of the municipality's six core urban barrios. It was organized in 1878. Barrio Segundo has 3 subbarrios: Baldority de Castro (or just "Baldorioty"), Clausells, and Reparada.

Albergue Caritativo Tricoche or Hospital Tricoche (English: Tricoche Charitable Shelter or Tricoche Hospital) is a historic building located on Calle Tricoche street in Ponce, Puerto Rico, in the city's historic district. It was designed by the Spanish Royal Corps of Engineers. The architecture consists of 19th-century civil architecture. When built in 1878, "it held the top spot among public building in Puerto Rico," based on its size and beauty.The hospital was named after Valentin Tricoche, a 19th-century philanthropist and land owner in Ponce with lands on the western bank of Rio Bucana which included lands with a stone mine. Valentin Tricoche left moneys in his will for the construction of the hospital. Construction started on 30 May 1873, it was delivered to the Municipal government by the Spanish Royal Corps of Engineers in September 1876, and opened to the public on 11 December 1878. The structure was built articulated in the Classical revival style. By 1885, the hospital was expanded with an annex which was named "Hospital Civil de Ponce", to differentiate it from the original hospital built with funds from Valentin Tricoche.The historic structure was listed on the U.S. National Register of Historic Places on 14 May 1987.

Calle 25 de Enero (lit., 25th of January Street) is a street and historic Victorian block located in barrio Segundo in Ponce, Puerto Rico, built to house Ponce's volunteer firemen and their families, after the historic fire that took place in the city on 25 January 1899, in appreciation for their labor on that fateful day.This picturesque street is lined with 39 red-striped and black-striped houses, the local firefighters’ colors. The street takes its name from the historic fire that took place in the town on that day in 1899. Since then, and for a number of years, the city of Ponce built new homes on this street and then drew lots to see which of its firemen would be the lucky owners of these free new properties.

The Centro Ponceño de Autismo (English: Ponce Autism Center), or CEPA, is the only center specialized in the diagnosis and treatment of autism in Puerto Rico. It is a non-profit organization. The center leads progressive research studies and medical training while providing comprehensive, personalized care to children and adults with Autism Spectrum Disorders (ASD), including Asperger's Disorder and PDD NOS. Working together with families, the Centro Ponceño de Autismo aims to identify the causes of autism and advance effective treatments. In 2011, it was reported that the Center cared for 179 patients.