Panteón Nacional Román Baldorioty de Castro

Terminal de Transportación Pública Carlos Garay (Carlos Garay Public Transportation Terminal), formerly, Terminal de Carros Públicos Carlos Garay (Carlos Garay Carros Públicos Terminal), is a public transportation terminal for shared ride passengers and SITRAS bus system in Ponce, Puerto Rico. It is located on the block bounded by Calle Vives, Calle Unión, Calle Victoria and Calle Mendez Vigo, in the Ponce Historic Zone, two blocks northwest of the main city square, Plaza Las Delicias. It opened in 1987. On a typical weekday, approximately 500 passengers on about 40 buses and shared-ride vehicles use the station. The building is an example of 1960s urban renewal. When at its peak, the Carlos Garay terminal accommodates over 100 públicos.

Albergue Caritativo Tricoche or Hospital Tricoche (English: Tricoche Charitable Shelter or Tricoche Hospital) is a historic building located on Calle Tricoche street in Ponce, Puerto Rico, in the city's historic district. It was designed by the Spanish Royal Corps of Engineers. The architecture consists of 19th-century civil architecture. When built in 1878, "it held the top spot among public building in Puerto Rico," based on its size and beauty.The hospital was named after Valentin Tricoche, a 19th-century philanthropist and land owner in Ponce with lands on the western bank of Rio Bucana which included lands with a stone mine. Valentin Tricoche left moneys in his will for the construction of the hospital. Construction started on 30 May 1873, it was delivered to the Municipal government by the Spanish Royal Corps of Engineers in September 1876, and opened to the public on 11 December 1878. The structure was built articulated in the Classical revival style. By 1885, the hospital was expanded with an annex which was named "Hospital Civil de Ponce", to differentiate it from the original hospital built with funds from Valentin Tricoche.The historic structure was listed on the U.S. National Register of Historic Places on 14 May 1987.

Castillo Serrallés (English: Serralles Castle) is a mansion located in the city of Ponce, Puerto Rico, overlooking the downtown area (Ponce Pueblo). It was built during the 1930s for Juan Eugenio Serrallés, son of businessman Juan Serrallés, founder of Destilería Serrallés. The structure sits on a 2.5-acre (1.0 ha) exceedingly manicured property. Nowadays, the structure functions as a museum, Museo Castillo Serrallés, with information about the sugar cane and rum industries and its impact in the economy of Puerto Rico. It is also increasingly used as a venue for social activities, including destination weddings. The property was listed in the National Register of Historic Places in 1980. In 1996, the structure was featured in the American TV series America's Castles.

Museo Castillo Serrallés (English: Serrallés Castle Museum), a.k.a. Museo de la Caña y el Ron (English: Sugar Cane and Rum Museum), is an agricultural museum in the city of Ponce, Puerto Rico, that showcases the history of sugar cane, its derivative rum industry, and their impact in the economy of Puerto Rico. The most notorious feature of the museum is the building it occupies. The building is a large four-story structure built in the 1930s for the owner of Ponce's Destileria Serralles, one of Puerto Rico's largest rum distilleries. The distillery was once also home to Puerto Rico's largest sugar-factory called Central Mercedita, producers of the Snow White sugar brand. The building, known as Castillo Serrallés, was designed by Pedro Adolfo de Castro in 1930 in the Spanish Colonial Revival style.The museum sits on a 2.5-acre lot and opened on 20 February 1991. Visitors can tour the refurbished home, which has been furnished to appear as it did in the 1930s. There is also a temporary exhibit area for local artists. The Serrallés Castle is now part of a large complex that includes the Cruceta El Vigía, a Japanese Garden, and a butterfly garden (Mariposario). By September 2010, the museum was receiving around 100,000 visitors per year.

The Centro Ponceño de Autismo (English: Ponce Autism Center), or CEPA, is the only center specialized in the diagnosis and treatment of autism in Puerto Rico. It is a non-profit organization. The center leads progressive research studies and medical training while providing comprehensive, personalized care to children and adults with Autism Spectrum Disorders (ASD), including Asperger's Disorder and PDD NOS. Working together with families, the Centro Ponceño de Autismo aims to identify the causes of autism and advance effective treatments. In 2011, it was reported that the Center cared for 179 patients.

Segundo (Barrio Segundo) is one of the 31 barrios of the municipality of Ponce, Puerto Rico. Along with Primero, Tercero, Cuarto, Quinto, and Sexto, Segundo is one of the municipality's six core urban barrios. It was organized in 1878. Barrio Segundo has 3 subbarrios: Baldority de Castro (or just "Baldorioty"), Clausells, and Reparada.

The Miguel C. Godreau House (Spanish: Casa Miguel C. Godreau) is a historic residence located in the historic zone of the municipality of Ponce, Puerto Rico. The house was designed by architects Julio Conesa and Julio Morales and was built in 1919. It was listed in the National Register of Historic Places (NRHP) in 1986.

The Luis A. Ferré United States Courthouse and Post Office Building (aka, Correo de la Calle Atocha) in Ponce, Puerto Rico, previously known as the U.S. Post Office and Court House, is a historic post office and courthouse facility of the United States, housing operations of the United States District Court for the District of Puerto Rico. It was the first U.S. postal office established in Puerto Rico.The building was designed by the Office of the Supervising Architect under James A. Wetmore and was built in 1933. In 2003 it was renamed the Luis A. Ferré United States Courthouse and Post Office Building by an Act of the U.S. Congress. The building sits at the same location where the Ponce Trainway depot used to be. The building is located on the southwest corner of Atocha and Guadalupe streets, facing Calle Atocha. The building suffered a major fire on 5 March 2018 which totally disabled and halted all postal activity processing activities at the facility.

Cerro del Vigía is a hill in the municipality of Ponce, Puerto Rico, located just north of the city of Ponce. A tourist destination, it is home to Museo Castillo Serrallés, Cruceta del Vigía, and the former Hotel Ponce Intercontinental. The 456-foot high hill sits at the foothills of the Cordillera Central and is located in Barrio Portugués Urbano. The hill is home to several well-to-do mansions of which the best known is Castillo Serrallés, now a Museum.

Cruceta del Vigía (English: The Watchman Cross) is a 100 feet (30 m) tall cross located atop Cerro del Vigía in Ponce, Puerto Rico, across from Museo Castillo Serrallés. It houses a tourist center at its base, a ten-story vertical tower, and a horizontal sky bridge that has panoramic views of the city of Ponce and the Caribbean Sea. Visitors can reach the skybridge via glass elevators or a staircase. Made of reinforced concrete, the cross has withstood various natural disasters, including three major hurricanes. The arms of the cross measure 70 feet. It was inaugurated in 1984.One of many landmarks of the city of Ponce, the cross is owned by the Municipality of Ponce and is currently operated by the "Patronato de Ponce", a non-profit organization dedicated to preserving the city's cultural heritage. It is visited annually by some 100,000 tourists.

Casa Wiechers-Villaronga is a Classical Revival style mansion in Ponce, Puerto Rico designed and built in the early twentieth century. The house was acquired and restored by the Institute of Puerto Rican Culture and now operates as the Museo de la Arquitectura Ponceña (Museum of Ponce Architecture). The house sits in the Ponce Historic Zone. The Villaronga Residence is an outstanding example of the Classical Revival style in used in Ponce designs in the early part of the 20th century and is one of two residences still standing of a series of houses designed and built by Alfredo B. Wiechers, so important to the architectural and cultural heritage of the city of Ponce.

The Museo de la Arquitectura Ponceña (Museum of Ponce Architecture) is an architecture museum housed at the Casa Wiechers-Villaronga, in Ponce, Puerto Rico. It is preserves the history of the architectural styles of Ponce and Puerto Rico. The Casa Wiechers-Villaronga was acquired and restored by the Institute of Puerto Rican Culture. The museum is located in the Ponce Historic Zone. The historic house was designed and built in 1912 by Alfredo B. Wiechers. The house that is home to this architecture museum is itself an example of the architectural history of the city. The museum is housed at the historic Casa Wiechers-Villaronga.