Luis A. Ferré United States Courthouse and Post Office Building

Plaza del Mercado de Ponce (English: Ponce Market Plaza) or, formally, Plaza del Mercado Isabel Segunda (often abbreviated as Plaza del Mercado Isabel II), is a historic marketplace building in Ponce, Puerto Rico. It was inaugurated in 1863 by Ponce Mayor Don Luis de Quixano. Designed by famed engineer Timoteo Luberza, it occupies a city block in the Ponce Historic Zone at the grid formed by Calle Atocha, Estrella, Leon, and Castillo streets. It has room for 65 kiosks. It was originally called Plaza del Capá.

Mercado de las Carnes (English: Meat Market), also known as La Plaza de los Perros (English: Dogs' Plaza), but formally, Plaza Juan Ponce de León (Juan Ponce de León Plaza), was the first building in Puerto Rico to mix social and architectural elements via the pedestrian mall concept. The historic Art Deco architecture structure is located in Ponce, Puerto Rico, and dates from 1926. It was listed on the National Register of Historic Places in 1986. The Plaza was rebuilt in 1992, under the administration of Mayor Churumba. It is located in the alley connecting Mayor and Leon streets, in the block between Estrella and Guadalupe streets. The Plaza and the alley are one and the same.

Albergue Caritativo Tricoche or Hospital Tricoche (English: Tricoche Charitable Shelter or Tricoche Hospital) is a historic building located on Calle Tricoche street in Ponce, Puerto Rico, in the city's historic district. It was designed by the Spanish Royal Corps of Engineers. The architecture consists of 19th-century civil architecture. When built in 1878, "it held the top spot among public building in Puerto Rico," based on its size and beauty.The hospital was named after Valentin Tricoche, a 19th-century philanthropist and land owner in Ponce with lands on the western bank of Rio Bucana which included lands with a stone mine. Valentin Tricoche left moneys in his will for the construction of the hospital. Construction started on 30 May 1873, it was delivered to the Municipal government by the Spanish Royal Corps of Engineers in September 1876, and opened to the public on 11 December 1878. The structure was built articulated in the Classical revival style. By 1885, the hospital was expanded with an annex which was named "Hospital Civil de Ponce", to differentiate it from the original hospital built with funds from Valentin Tricoche.The historic structure was listed on the U.S. National Register of Historic Places on 14 May 1987.

Casa Vives (Vives House) is a historic building located in the Ponce Historic Zone in Ponce, Puerto Rico, across from the Plaza de Mercado de Ponce. The home was designed by Juan Bertoli Calderoni for Carlos Vives, a prominent local merchant and owner of Hacienda Buena Vista, and built by Carlos Milan. The home was built in 1860, in the neoclassical style, making it one of the first brick and mortar homes built in the city. It was added to the U.S. National Register of Historic Places on 13 February 2013. Architecturally, Casa Vives retains all seven aspects of integrity: location, design, setting, materials, workmanship, feeling and association.

Archivo Histórico de Ponce, officially, Archivo Histórico de Ponce Gladys E. Tormes González, is a historical archive in Ponce, Puerto Rico. It is considered "the most complete historical archive in Puerto Rico".

Ponce Servicos, formerly Plaza del Mercado Juan Bigas, is a brutalist municipal building located Ponce, Puerto Rico. It is the largest building in the municipality in terms of footprint area and the only one that occupies an entire city block. The structure was built in 1981 as a way to provide a modern, air-conditioned, structure for the merchants and shoppers of the historic but aging Plaza de Mercado Isabel II building, while the latter underwent restoration. On its opening day it was named Plaza del Mercado Juan Bigas, in honor of Juan Bigas Moulins, the Ponce businessman by that name. Upon its opening, some of the former fruits-and-vegetables merchants from the old Plaza del Mercado Isabel II building moved in, but many did not. Objections ranged from rent being too high to not providing the friendly atmosphere of the old Isabel II building provided because many perceived this brutalist architecture building as one that did not carry on the important city historic values conveyed by the old Art Deco Plaza del Mercado Isabel II building. In spite of these objections, the new building was used as a fruits-and-vegetables farm market plaza for 26 years, until 2007, when the restoration of the older Isabel II building was completed. On that year (2007), Plaza del Mercado Juan Bigas building was vacated, and merchants moved back to restored Plaza del Mercado Isabel II building, and the building came to be known simply as the Juan Bigas Building. The Juan Bigas building then sat unused for three years, until 2010. In that year, after negotiations between the central and municipal governments, the Government of Puerto Rico transferred the structure to the Ponce Municipal Government. The Ponce municipal government reconditioned the building, now no longer called Plaza del Mercado Juan Bigas, but simply Edificio Juan Bigas (Juan Bigas Building) for use as office space for several municipal agencies. In October 2013, the Ponce Municipal Government reopened the building as a multi-agency municipal building offering a mix of municipal services to its residents and christened it "Ponce Servicios" (Ponce Services).

Terminal de Transportación Pública Carlos Garay (Carlos Garay Public Transportation Terminal), formerly, Terminal de Carros Públicos Carlos Garay (Carlos Garay Carros Públicos Terminal), is a public transportation terminal for shared ride passengers and SITRAS bus system in Ponce, Puerto Rico. It is located on the block bounded by Calle Vives, Calle Unión, Calle Victoria and Calle Mendez Vigo, in the Ponce Historic Zone, two blocks northwest of the main city square, Plaza Las Delicias. It opened in 1987. On a typical weekday, approximately 500 passengers on about 40 buses and shared-ride vehicles use the station. The building is an example of 1960s urban renewal. When at its peak, the Carlos Garay terminal accommodates over 100 públicos.

Fundación Biblioteca Rafael Hernández Colón (English: Rafael Hernández Colón Foundation Library) is a gubernatorial library and museum that records the political life of three-term governor of Puerto Rico, Rafael Hernández Colón. It was founded in 1992 and in September 2015 it moved to its current location at the southeast corner of Calle Mayor and Calle Castillo in Ponce, Puerto Rico, in the Ponce Historic Zone.

Paseo Atocha is a pedestrian shopping mall in the Ponce Historic Zone, a historic district in Ponce, Puerto Rico. For over a century the narrow Calle Atocha was bustling retail center opened to vehicular traffic, yet flooded with shoppers. Congestion and pedestrian safety led the municipal government to close the two blocks of Calle Atocha from Calle Isabel to Calle Vives to motor vehicles in 1991. Several years later, the closure was expanded to include the block from Calle Vives to Calle Victoria. This last segment coincides with the western perimeter of the historic Plaza de Mercado Isabel II city market. Not the bustling commercial spot it once was, today it is still actively frequented by shoppers, though in much reduced numbers. It is visited annually by thousands of locals and tourists alike and is considered one of the city’s main places of interest.

Teatro Fox Delicias is a historic building in the city of Ponce, Puerto Rico. Inaugurated in 1931, it originally housed a movie house until 1980, from 1991 to 1998 it house a shopping mall, and stating in 2004 it housed a boutique hotel. Its architecture is Art Deco. Originally called Teatro Delicias, it was renamed Fox Delicias many years after its inauguration based on a contract with 20th Century Fox.

The Antiguo Hospital Militar Español de Ponce (English: Old Spanish Military Hospital in Ponce) is a historic building in Ponce, Puerto Rico, in the city's historic district. The building dates from 1896 or 1897. It was designed by the Spanish Royal Corps of Engineers. The architecture consists of 19th Neoclassical architecture style. The building is of architectural significance since it is the only one-story building of this style remaining in the city of Ponce and one of the best examples on the Island. Completed in 1897, the year before the Spanish–American War of 1898, this building was the last major construction undergone by the Spanish Government in the Americas. From 1905 to the mid 1970s the structure served as the Asilo de Ciegos de Ponce (Ponce Blind Asylum). As of 2020 the building sits abandoned.

Casa Font-Ubides (English: Font-Ubides House), also known as the Residencia Monsanto (English: Monsanto Residence) is a historic building located on the north side of Castillo Street in Ponce, Puerto Rico, in the city's historic district. The building dates from 1913. It was designed by the architect Blas Silva. The architecture consists of 19th Classical revival and Art Nouveau architectural styles. The building is of architectural significance for its aggressive incorporation of curvilinear forms and ornaments. The complete preservation of the original architecture of the Monsanto Residence, its unique design amongst the houses of Ponce, and its location within the historic urban core of the city qualify it as one of a series of grand houses and an integral part of the character of Ponce.