Regina Apostolorum Academy

The Philippine Chung Hua School (PCHS) is located at 3217 Reposo Street, Santa Mesa, Manila, Philippines. The school teaches Chinese and Filipino, as well as English.

Victorino Mapa Street, also known by its short form V. Mapa Street, is the main north–south road in the district of Santa Mesa in Manila, Philippines. The street, including its eastern extension, runs for 1.6 kilometers (0.99 mi) from the junction with Magsaysay Boulevard in the north to Pat Antonio Street in the southeast by the San Juan River that serves as the district's border with San Juan and Mandaluyong. It is home to Don Bosco School, Manila, Unciano Colleges and General Hospital, and several new condominiums and a few motels. A portion of the street forms part of Radial Road 5 (R-5) of Manila's arterial road network where it links with Padre Sanchez Street (named after Jesuit priest Francisco de Paula Sanchez from the Ateneo Municipal de Manila) and eventually connects to Shaw Boulevard in Mandaluyong. It is served by V. Mapa LRT Station along Magsaysay Boulevard. Its section from its northern terminus at Magsaysay Boulevard to Valenzuela Street is designated as part of National Route 183 (N183), while its section from Valenzuela Street to P. Sanchez Street is designated as part of National Route 141 (N141); both numbered routes are part of the Philippine highway system. The rest of the route up to Pat Antonio Street is an unnumbered street.

Santa Mesa is a district in Manila, Philippines. It is surrounded by Pasig River on the southwestern side, and by the San Juan River on its southern and eastern side. Land borders include the districts of San Miguel to the west and Sampaloc to the north; and to the northeast is Quezon City. Santa Mesa was formerly a part of the Sampaloc district, from which it was partitioned and separated after it had its own parish in 1911. The parish is now known as Old Sta. Mesa (Poblacion), which extends from Victorino Mapa Street to Magsaysay Boulevard. (formerly known as Santa Mesa Boulevard and Calle Santa Mesa)

Unciano Colleges (UC), Inc. is a private school with branches in Sta. Mesa, Manila and in Antipolo. The institution is known for its medical science programs and is affiliated the Unciano Colleges and General Hospital in Manila (45years). The Antipolo campus has been providing tertiary education for 29 years now. It provides undergraduate courses in Medical Technology, Nursing, Physical Therapy, and Radiologic Technology. Aside from these allied health courses, the campus also has a Hospitality and Tourism Management department with BS Hotel and Restaurant Management and BS Tourism Management. Additionally, the school currently offers basic education, including Senior High School (SHS). Interested SHS students have the option of choosing between the ABM strand and the STEM strand.

The Polytechnic University of the Philippines Laboratory High School (Filipino: Sanayang Mataas na Paaralan ng Politeknikong Unibersidad ng Pilipinas), abbreviated as PUPLHS, is the laboratory school of the Polytechnic University of the Philippines College of Education located in PUP Mabini Campus, Sta. Mesa, Manila. It was established in 1954 as the Philippine College of Commerce High School offering commercial courses, and is the first high school to offer commercial curriculum in the Philippines. The school has a student population of 541 in 2015.

Polytechnic University of the Philippines (PUP; Filipino: Politeknikong Unibersidad ng Pilipinas) is a research and coeducational state university in Manila, Philippines. It was founded on 19 October 1904, as the Manila Business School (MBS) and as part of Manila's public school system. It was eventually promoted to chartered state university in 1978, by virtue of Presidential Decree 1341. PUP has more than 20 campuses and extensions across Central Luzon, Southern Luzon and Metro Manila. With over 70,000 enrolled students, PUP claims to be the largest state university in the Philippines by student population. In 2013, PUP ranked 300+ in the QS Asia University Rankings. In the same year, the QS World University Rankings Country File on the Philippines also placed PUP third in Life Science and Medicine, fifth in Natural Science (Chemistry), fourth in Economics and Econometrics, and fifth in Communication and Media Studies. 58 PUP programs have been accredited by the Accrediting Agency of Chartered Colleges and Universities in the Philippines (AACCUP) while 2 (Journalism and Filipino) were granted Center of Development status by the Commission on Higher Education. A 2018 survey of 503 JobStreet employers ranked PUP as the top choice of employers in general, the top choice in the business process outsourcing (BPO) industry, and the second choice in the Manufacturing, IT, and Banking industries. The Universal Access to Quality Tertiary Education Act of 2017 mandates free tuition and fees for all students of state universities and colleges. Before the act was enforced, the tuition was exactly ₱12 (roughly 24 US cents) per unit (Since 1979) for undergraduate students. Students may opt out of the subsidy and choose to pay the full tuition instead. PUP has a reputation for student activism against tuition fee hikes.PUP's athletic team is known as the Mighty Maroons and plays in the National Capital Region Conference of the State Colleges and Universities Athletic Association (SCUAA). The team also played in the National Athletic Association of Schools, Colleges and Universities (NAASCU) in 2013. Its official volleyball team, the PUP Lady Radicals, played in the Shakey's V-League in 2015.

The Polytechnic University of the Philippines College of Law, abbreviated as CL, is the law school of the Polytechnic University of the Philippines located in Manila, Philippines that was established in 2001. It ranks as one of the top law schools in the country in terms of percentile passing rate in the bar examination.

The Ninoy Aquino Library and Learning Resources Center (NALLRC) is the library system of the Polytechnic University of the Philippines composed of libraries providing services to the PUP System. Its headquarters is in the building of the same name, located in Manila, Philippines. NALLRC offers various services and development of programs to its clientele. The NALLRC Main Library is regarded as one of the largest libraries in Southeast Asia. The building is also home to the university's College of Law and Open University System.

The University Center for Culture and the Arts (UCCA) is a non-profit cultural center of the Polytechnic University of the Philippines. The agency is under the Office of the Vice President for Student Services. The UCCA is currently residing at the PUP Theater inside the PUP College of Communication compound. The UCCA hosts various events inside and outside the university. On August 29, 2014, the Polytechnic University of the Philippines through UCCA conferred the 'Pambansang Artista Ng Mamamayan' award to Nora Aunor in the PUP Theater. The UCCA also spearheads the annual university Arts Month every February.

Sacred Heart of Jesus Catholic School (SHJCS) is a private Catholic school located in Santa Mesa, Manila, beside this is the Sacred Heart of Jesus Parish. The school's name is named after their parish patron, Sacred Heart of Jesus. The school was formerly known as Sta. Mesa Parochial School. The director of the school is the Rev. Fr. Marion C. Munda and the principal is Dr. Henry A. Davalos.

Don Bosco School Manila (full school name: Don Bosco School (Salesian Sisters), Inc. - Manila, also known as DBS), is an educational institution owned and operated by the Daughters of Mary Help of Christians (FMA) in the National Capital Region of the Philippines. Established in 1989, Don Bosco School Manila offers co-educational education for primary (elementary) and secondary education (high-school and senior high school). Don Bosco School also offers night school (Alternative Learning System).

Santa Mesa station is a railway station located on the South Main Line in the city of Manila, Philippines. It is one of two stations (the other is Pasay Road) in the line to have its own access road. The station is the fourth station southbound from Tutuban and is the only railway station serving Santa Mesa. In addition to having its own dedicated access road, Santa Mesa station is also one of three stations (the others being Pasay Road and España) to have its original platforms extended and raised in order to accommodate new PNR diesel multiple units. The original platforms have been retained for the use of Commuter Express locomotives and especially for intercity trains, although Santa Mesa is not designated as a station where these trains can stop. The station used to serve the Santa Mesa-Mandaluyong branch line, also known as Guadalupe line, which used to run up to Antipolo and Montalban. This line has since been dismantled.