Sacred Heart of Jesus Catholic School

Santa Mesa station is a railway station located on the South Main Line in the city of Manila, Philippines. It is one of two stations (the other is Pasay Road) in the line to have its own access road. The station is the fourth station southbound from Tutuban and is the only railway station serving Santa Mesa. In addition to having its own dedicated access road, Santa Mesa station is also one of three stations (the others being Pasay Road and España) to have its original platforms extended and raised in order to accommodate new PNR diesel multiple units. The original platforms have been retained for the use of Commuter Express locomotives and especially for intercity trains, although Santa Mesa is not designated as a station where these trains can stop. The station used to serve the Santa Mesa-Mandaluyong branch line, also known as Guadalupe line, which used to run up to Antipolo and Montalban. This line has since been dismantled.

Ramon Magsaysay Boulevard, also known simply as Magsaysay Boulevard and formerly as Santa Mesa Boulevard, is the principal artery of Santa Mesa in Manila, Philippines. It is a six-lane divided roadway that travels east–west from Gregorio Araneta Avenue near the city's border with Quezon City and San Juan to Lacson Avenue and the Nagtahan Interchange, close to the district of San Miguel. The entire length of the boulevard serves as the boundary between Sampaloc in the north and Santa Mesa in the south with the LRT Line 2 running along its median. East of Gregorio Araneta, the road continues as Aurora Boulevard while west of Lacson, it extends as Legarda Street via Legarda Flyover into San Miguel and Quiapo. The LRT Line 2 has two stations along Magsaysay, namely Pureza and V. Mapa. It is also served by the Santa Mesa railway station near the Polytechnic University of the Philippines campus on Hipodromo and Anonas Streets. The boulevard was named after the seventh president of the Philippines, Ramon Magsaysay. It was formerly called Santa Mesa Boulevard, which in turn was formerly called Calle Santa Mesa. It also formed part of Highway 53. The road now known as Old Santa Mesa Street was part of the original Calle Santa Mesa, up to the San Juan Bridge, wherein what is now the current alignment of Ramon Magsaysay Boulevard was later extended from Santol Street to Quezon City. Its present-day section between Nagtahan and Old Santa Mesa Road was also the former right-of-way of tranvia until 1945.

The Ninoy Aquino Library and Learning Resources Center (NALLRC) is the library system of the Polytechnic University of the Philippines composed of libraries providing services to the PUP System. Its headquarters is in the building of the same name, located in Manila, Philippines. NALLRC offers various services and development of programs to its clientele. The NALLRC Main Library is regarded as one of the largest libraries in Southeast Asia. The building is also home to the university's College of Law and Open University System.

The University Center for Culture and the Arts (UCCA) is a non-profit cultural center of the Polytechnic University of the Philippines. The agency is under the Office of the Vice President for Student Services. The UCCA is currently residing at the PUP Theater inside the PUP College of Communication compound. The UCCA hosts various events inside and outside the university. On August 29, 2014, the Polytechnic University of the Philippines through UCCA conferred the 'Pambansang Artista Ng Mamamayan' award to Nora Aunor in the PUP Theater. The UCCA also spearheads the annual university Arts Month every February.

The Polytechnic University of the Philippines College of Law, abbreviated as CL, is the law school of the Polytechnic University of the Philippines located in Manila, Philippines that was established in 2001. It ranks as one of the top law schools in the country in terms of percentile passing rate in the bar examination.

The Battle of Manila (Filipino: Labanan sa Maynila; Spanish: Batalla de Manila), the first and largest battle of the Philippine–American War, was fought on February 4–5, 1899, between 19,000 American soldiers and 15,000 Filipino armed militiamen. Armed conflict broke out when American troops, under orders to turn away insurgents from their encampment, fired upon an encroaching group of Filipinos. Philippine President Emilio Aguinaldo attempted to broker a ceasefire, but American General Elwell Stephen Otis rejected it and fighting escalated the next day. It ended in an American victory, although minor skirmishes continued for several days afterward.

The Polytechnic University of the Philippines Laboratory High School (Filipino: Sanayang Mataas na Paaralan ng Politeknikong Unibersidad ng Pilipinas), abbreviated as PUPLHS, is the laboratory school of the Polytechnic University of the Philippines College of Education located in PUP Mabini Campus, Sta. Mesa, Manila. It was established in 1954 as the Philippine College of Commerce High School offering commercial courses, and is the first high school to offer commercial curriculum in the Philippines. The school has a student population of 541 in 2015.

Polytechnic University of the Philippines (PUP; Filipino: Politeknikong Unibersidad ng Pilipinas) is a research and coeducational state university in Manila, Philippines. It was founded on 19 October 1904, as the Manila Business School (MBS) and as part of Manila's public school system. It was eventually promoted to chartered state university in 1978, by virtue of Presidential Decree 1341. PUP has more than 20 campuses and extensions across Central Luzon, Southern Luzon and Metro Manila. With over 70,000 enrolled students, PUP claims to be the largest state university in the Philippines by student population. In 2013, PUP ranked 300+ in the QS Asia University Rankings. In the same year, the QS World University Rankings Country File on the Philippines also placed PUP third in Life Science and Medicine, fifth in Natural Science (Chemistry), fourth in Economics and Econometrics, and fifth in Communication and Media Studies. 58 PUP programs have been accredited by the Accrediting Agency of Chartered Colleges and Universities in the Philippines (AACCUP) while 2 (Journalism and Filipino) were granted Center of Development status by the Commission on Higher Education. A 2018 survey of 503 JobStreet employers ranked PUP as the top choice of employers in general, the top choice in the business process outsourcing (BPO) industry, and the second choice in the Manufacturing, IT, and Banking industries. The Universal Access to Quality Tertiary Education Act of 2017 mandates free tuition and fees for all students of state universities and colleges. Before the act was enforced, the tuition was exactly ₱12 (roughly 24 US cents) per unit (Since 1979) for undergraduate students. Students may opt out of the subsidy and choose to pay the full tuition instead. PUP has a reputation for student activism against tuition fee hikes.PUP's athletic team is known as the Mighty Maroons and plays in the National Capital Region Conference of the State Colleges and Universities Athletic Association (SCUAA). The team also played in the National Athletic Association of Schools, Colleges and Universities (NAASCU) in 2013. Its official volleyball team, the PUP Lady Radicals, played in the Shakey's V-League in 2015.

Unciano Colleges (UC), Inc. is a private school with branches in Sta. Mesa, Manila and in Antipolo. The institution is known for its medical science programs and is affiliated the Unciano Colleges and General Hospital in Manila (45years). The Antipolo campus has been providing tertiary education for 29 years now. It provides undergraduate courses in Medical Technology, Nursing, Physical Therapy, and Radiologic Technology. Aside from these allied health courses, the campus also has a Hospitality and Tourism Management department with BS Hotel and Restaurant Management and BS Tourism Management. Additionally, the school currently offers basic education, including Senior High School (SHS). Interested SHS students have the option of choosing between the ABM strand and the STEM strand.

Santa Mesa is a district in Manila, Philippines. It is surrounded by Pasig River on the southwestern side, and by the San Juan River on its southern and eastern side. Land borders include the districts of San Miguel to the west and Sampaloc to the north; and to the northeast is Quezon City. Santa Mesa was formerly a part of the Sampaloc district, from which it was partitioned and separated after it had its own parish in 1911. The parish is now known as Old Sta. Mesa (Poblacion), which extends from Victorino Mapa Street to Magsaysay Boulevard. (formerly known as Santa Mesa Boulevard and Calle Santa Mesa)

The Philippine Chung Hua School (PCHS) is located at 3217 Reposo Street, Santa Mesa, Manila, Philippines. The school teaches Chinese and Filipino, as well as English.

Regina Apostolorum Academy is a private non-sectarian school located in Santa Mesa, Manila,.The school's name is named after their Queen of Apostles. The school was formerly known as Angelicum School. The director of the school is the Ms. Teresa Tuason and the principal is Ms. Janette Liwanag.