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Cristo Rey Jesuit High School is a Jesuit high school on the near Lower West Side of Chicago, Illinois. It is the founding school of the Cristo Rey Network and is affiliated with the Roman Catholic Archdiocese of Chicago. Cristo Rey Jesuit High School was established in 1996 and provides college-preparatory education. The school places students at entry-level jobs that cover some of their tuition costs.

Lower West Side is a community area on the West Side of Chicago, Illinois, United States. It is three miles southwest of the Chicago Loop and its main neighborhood is Pilsen (). The Heart of Chicago is a neighborhood in the southwest corner of the Lower West Side.

Benito Juarez Community Academy, (commonly known as Juarez High School), is a public 4–year high school in the Pilsen neighborhood on the west side of Chicago, Illinois, United States. Juarez is named for Mexican president Benito Pablo Juárez García. The school is a part of the Chicago Public Schools (CPS) district. As of 2014 it is the largest high school in Pilsen. It was designed by architect Pedro Ramírez Vázquez. The school was proposed to the Chicago Board of Education multiple times but ultimately rejected. This led to protests and boycotts from many Mexican students and families. Finally, in June 1974, the Chicago Board of Education approved $8.9 million in funding to build a high school in Pilsen. Benito Juarez Community Academy opened in 1977 and as of 2017 has a 94 percent Latino student body. The school is decorated with murals and statues that portray Mexican culture and famous leaders.

St. Vitus's Church Complex was a former late-nineteenth-century Roman Catholic church located in Pilsen, Chicago, Illinois at 1814 South Paulina Street, and corner of 18th Street. The church itself was closed in 1990 and the rectory and remaining space adaptively reused as the Guadalupano Family Center, a daycare and cultural center thereafter. The complex contained a 4,500-square-foot (420 m2) church (1896–1897), rectory (1898), and parish school (1902). The complex was closed 1990. The National Trust for Historic Preservation profiled the structure as a good example of adaptive reuse: "A community task force collaborated with area interfaith organizations to develop a non-profit community development corporation called The Resurrection Project. This group was organized to specifically focus on developing and overseeing uses for the complex, as well as developing numerous low-income and affordable housing units and residences in the area." The church was renovated 1992-1996 as a "state-of-the-art day care facility was designed for the former parochial school, and plans are underway for a cultural center in the now hollow sanctuary space that was destroyed by a fire….The Resurrection Project operates one of the most active community reinvestment programs in the area from the [church]," costing $1.2 million for conversion of school and $400,000, anticipated repairs to church.Its location in a Latino neighborhood enabled its large number of parishioners to work with the Roman Catholic Archdiocese of Chicago to explore reuse options with a team of architects, urban planners, historic preservationists, low-income housing specialists, commercial developers, and educators to create Guadalupano Family Center, a day care and cultural activity center. Opened in 1994, the child care facility "that operates on a sliding scale fee, serving the population of 6,000 children between 3 and 12 years of age living within 1/2 mile of the center. The center also employs a staff of 22 teachers."

The National Museum of Mexican Art (Formerly known as the Mexican Fine Arts Center Museum) is a museum which features Mexican, Latino, and Chicano art and culture. The museum was founded in 1982 by Carlos Tortolero and Helen Valdez. Located in the Pilsen neighborhood of Chicago, Illinois, the current building in Harrison Park opened on March 27, 1987. The museum is the only Latino museum accredited by the American Alliance of Museums. The mission of the museum is to display Mexican culture as one sin fronteras (without borders). The museum describes itself as the largest Latino cultural institution in America.

18th is an 'L' station on the CTA's Pink Line. It is located at 1710 West 18th Street in the Pilsen neighborhood of Chicago, Illinois. The station is decorated with colorful murals painted by local artists from Pilsen.

St. Adalbert Church (Polish: Kościół Świętego Wojciecha) is a historic church of the Roman Catholic Archdiocese of Chicago. The church is located on 17th Street between Paulina Street and Ashland Avenue in the Pilsen neighborhood of Chicago, Illinois. St. Adalbert has served generations of Polish immigrants and their American-born children; at its peak, parish membership numbered 4,000 families with more than 2,000 children enrolled in the school. Today, the church is an anchor for the Mexican immigrants that have made the Pilsen area their home. The church is named after St. Adalbert of Prague. In June 2019, the Archdiocese of Chicago announced that the church would permanently close on July 15, 2019.

Chicago International Produce Market (or CIPM) is a wholesale produce market in Chicago, Illinois. It is the largest facility of its kind in the midwestern United States.

Damen is a station on the Chicago Transit Authority's 'L' system, serving the Pink Line and the Pilsen neighborhood.

St. Matthew Evangelical Lutheran School is a historic Lutheran school building located at 2101-2107 W. 21st Street in Chicago, Illinois. Built in 1882, it is one of the only surviving Italianate school buildings in Chicago. While the Italianate style was popular in Chicago in the second half of the 19th century, it was mainly used in homes and commercial buildings rather than institutional buildings, making the school's design uncommon even for its era. The school's distinctive Italianate features include its tall windows with arched lintels, its symmetrical front facade, its double bracketed cornice, and the cupola atop its roof. The school is also one of the oldest remaining school buildings in the Lower West Side and its adjacent community areas; only four older schools remain within these nine community areas, and St. Ignatius College Prep is the only older parochial school.The building was added to the National Register of Historic Places on January 27, 2000.

14th Place was a rapid transit station on the Chicago "L"'s Douglas Park branch between 1896 and 1951. Constructed by the Metropolitan West Side Elevated Railroad, it was one of the first stations opened on the branch in April 1896.

The Pilsen Historic District is a historic district located in the Pilsen neighborhood of Chicago. Pilsen is a neighborhood made up of the residential sections of the Lower West Side community area of Chicago. In the late 19th century Pilsen was inhabited by Czech immigrants who named the district after Pilsen, the fourth largest city in Czechia. The population also included in smaller numbers other ethnic groups from the Austro-Hungarian Empire including Slovaks, Slovenes, Croats and Austrians, as well as immigrants of Polish and Lithuanian heritage. The Czechs had replaced the Germans, who had settled there first with the Irish in the mid-19th century. Although there was an increasing Mexican American presence in the late 1950s, it was not until 1962-63 when there was a great spurt in the numbers of Mexican Americans in Pilsen due to the destruction of the neighborhood west of Halsted Street between Roosevelt and Taylor Streets to create room for the construction of the University of Illinois at Chicago. Although this area was predominantly Italian American, it was also an important entry point for Mexican immigrants for several decades. Latinos became the majority in 1970 when they surpassed the Slavic population. The neighborhood continued to serve as port of entry for immigrants, both legal and illegal, mostly of Mexican descent. Pilsen's Mexican population is increasingly dwarfed by what has become the largest Mexican neighborhood in Chicago, Little Village. Pilsen became a National Historic Register District on February 1, 2006.