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Rosetta is a restaurant in Colonia Roma, Cuauhtémoc, Mexico City, that has served Mexican cuisine with Mediterranean influences (mainly Italian) since 2010. It serves seasonal à la carte options. It is owned by chef Elena Reygadas, who studied at the International Culinary Center and worked at Locanda Locatelli in London. Food experts have given the restaurant favorable reviews, with plates of pasta and bread receiving the greatest attention. The British magazine Restaurant has ranked the restaurant twice on its list of the World's 50 Best Restaurants and Reygadas received their Best Female Chef of 2023 award. Rosetta was awarded one Michelin star in 2024 in the first Michelin Guide covering restaurants in Mexico.

Jenni's Quesadillas, alternatively known as Quesadillas Elenita, is a Mexican antojito food stand in Colonia Roma, Cuauhtémoc, Mexico City. Elena Rojas Vara opened the stand during the 1970s, at the intersection of Mérida and Colima Streets. Since then, the business has attracted local and foreign customers. Rojas is also assisted by Jenni, whose name was later associated with the stand.

Plaza Río de Janeiro (originally Plaza Roma) is a public park in Roma, Mexico City. It is east of Fuente de Cibeles and north of Plaza Luis Cabrera. The central feature of Plaza Río de Janeiro is a fountain with a replica of Michelangelo’s David. This plaza is surrounded by old mansions and modern residential buildings. The first name of the square was Parque Roma; later it was changed to Parque Orizaba, due to the North-South street that intersects the park. In 1922 it was renamed Plaza Río de Janeiro at the initiative of José Vasconcelos, then Secretary of Public Education, possibly because Mexico was invited to attend the celebration of the centenary of Brazil's independence that year.

Máximo Bistrot, also known as Máximo, is a Mexico City restaurant founded in 2011 by the chef Eduardo García and the restaurateur Gabriela López. Known for its daily menu and tasting menu, the restaurant offers dishes inspired by French cuisine techniques and made with seasonal Mexican ingredients. It emphasizes a farm-to-table concept, sourcing local ingredients, earning the restaurant praise for its dining approach. The restaurant was originally located in Tonalá Street, in Colonia Roma. In 2020, Máximo Bistrot was moved to a larger space on Avenida Álvaro Obregón, expanding its kitchen facilities and rebranding as Máximo. Despite the delay caused by the COVID-19 pandemic, the restaurant grew to employ 120 people. In 2021, The World's 50 Best Restaurants gave the restaurant an award for its reinvention. In 2013, Máximo Bistrot became the focus of national controversy when the daughter of Mexico's consumer protection chief (PROFECO), attempted to bypass the reservation system and later prompted a temporary closure by PROFECO inspectors. The incident sparked public backlash over abuse of power, leading to the chief's dismissal and the sanctioning of several officials.

The Casa Lamm Cultural Center is the best known landmark in Colonia Roma. It was a house built in the early 20th century when Colonia Roma was a new neighborhood for the wealthy leaving the historic center of Mexico City. In the 1990s, the house was restored to open as a cultural center in 1994, with the aim of making the area a center for the visual arts. Today, it hosts numerous exhibits as well as offering classes, even degrees, in art and literature.

OMR is a contemporary art gallery located in Mexico City.

Salón de la Plástica Mexicana (Hall of Mexican Fine Art; SPM) is an institution dedicated to the promotion of Mexican contemporary art. It was established in 1949 to expand the Mexican art market. Its first location was in historic center of the city but today it mostly operates out of a building in Colonia Roma. The institution is run by a membership of almost four hundred recognized artists and holds multiple exhibitions each year. Although it operates autonomously, it is part of the Instituto Nacional de Bellas Artes y Literatura.

Licorería Limantour is a bar in Mexico City, Mexico. It opened in 2011.

Jesuit Migrant Service, Mexico (SJM-Mexico) was founded by the Society of Jesus in 2001, to offer a variety of services for the many migrants passing into, through, or out of Mexico, and to their families.

Garros Galería or Garros Gallery is located in Colonia Roma in Mexico City. It is the only art gallery and museum dedicated to cats in Mexico.

ORT University Mexico is a non-profit Institution founded in 2015 in Mexico City. Founded by board members Mauricio Merikanskas, Dan Ostrosky and Rogerio Casas Alatriste, and president Moises Salinas Fleitman, it was created in collaboration with the Private Assistance Board of Mexico City, in response to the growing need for professionalization in the social sector in Mexico. It is part of the global educational network of World ORT, an organization founded in Russia in 1880 and currently operating in over 60 countries, with more than 250,000 students. Its affiliated higher education institutions include Universidad ORT Uruguay, Los Angeles ORT College in the United States, and ORT Braude College of Engineering in Israel. ORT University Mexico is the only higher education institution in Latin America whose academic programs are fully focused on strengthening the social sector, also known as the third sector, with focus areas such as education, addiction prevention, environmental issues, human rights, and disability. The university collaborates with public institutions and NGOs, and maintains formal agreements with the Mexico City Private Assistance Board, the Instituto para la Atención y Prevención de las Adicciones (IAPA), and SEMARNAT (Mexico's Ministry of the Environment). In 2017, ORT University Mexico received a major USAID grant to train human rights organizations in the US-Mexico Border, . In December 2019, it received the **Alliances for Impact Award** from Fondo Unido México–United Way for its collaborative projects, and in May 2020, the university was recognized by *GANAR-GANAR* magazine as the best institution in Mexico to study social responsibility programs.

Plaza Luis Cabrera is a public space in Colonia Roma, Mexico City. It is a cafe-ringed plaza with trees and a fountain which memorializes Luis Cabrera Lobato. Plaza Luis Cabrera is located on Orizaba Street at Zacatecas Street. To its north is Plaza Río de Janeiro. In the 1950s the plaza was frequented by some American Beat Generation writers such as Jack Kerouac, William Burroughs, Allen Ginsberg and others. It hosted anti-Trump No Kings protests in 2025.