Calle 25 de Enero

Segundo (Barrio Segundo) is one of the 31 barrios of the municipality of Ponce, Puerto Rico. Along with Primero, Tercero, Cuarto, Quinto, and Sexto, Segundo is one of the municipality's six core urban barrios. It was organized in 1878. Barrio Segundo has 3 subbarrios: Baldority de Castro (or just "Baldorioty"), Clausells, and Reparada.

The Centro Ponceño de Autismo (English: Ponce Autism Center), or CEPA, is the only center specialized in the diagnosis and treatment of autism in Puerto Rico. It is a non-profit organization. The center leads progressive research studies and medical training while providing comprehensive, personalized care to children and adults with Autism Spectrum Disorders (ASD), including Asperger's Disorder and PDD NOS. Working together with families, the Centro Ponceño de Autismo aims to identify the causes of autism and advance effective treatments. In 2011, it was reported that the Center cared for 179 patients.

The Miguel C. Godreau House (Spanish: Casa Miguel C. Godreau) is a historic residence located in the historic zone of the municipality of Ponce, Puerto Rico. The house was designed by architects Julio Conesa and Julio Morales and was built in 1919. It was listed in the National Register of Historic Places (NRHP) in 1986.

Parque del Retiro (English: Retirement Park) is the only senior citizens-oriented passive park in Ponce, Puerto Rico. It is located in barrio Canas Urbano. The park commemorated its 30th anniversary on 11 February 2010. It has a "steady attendance" of some 70 senior citizens. The park's oldest member is 91 years old. The park's managing ranger is Roberto Castro Franceschi.

Colegio San Conrado is a private Catholic school in Ponce, Puerto Rico. It was founded in 1948 by the Capuchin Friars, under the direction of the Sisters of St. Joseph of Brentwood, New York. Currently the School is owned by the Diocese of Ponce and administered by the Sisters of Saint Joseph.

The Panteón Nacional Román Baldorioty de Castro (English: Román Baldorioty de Castro National Pantheon) is a tract of land in Barrio Segundo of the city of Ponce, Puerto Rico, originally designed as the city's cemetery, but later converted into what has come to be a famous burial place. Established in 1842, it is Puerto Rico's first (and only) national pantheon. It is the only cemetery dedicated as a museum in Puerto Rico and the Caribbean. Prior to being dedicated as a Panteón Nacional, it was known as Cementerio Viejo or as Cementerio Antiguo de Ponce, and is listed under that name on the U.S. National Register of Historic Places. The Pantheon is named after Román Baldorioty de Castro, a prolific Puerto Rican politician, and firm believer of Puerto Rican autonomy and independence. His remains are located here. The Pantheon also houses a small museum about the history of autonomism in the Island, and it is currently used both as a park and a venue for the expression of culture and the arts. It is called the Museo del Autonomismo Puertorriqueño. Prior to being turned into a National Pantheon in 1991, it was known as Antiguo Cementerio de Ponce (Ponce's Old Cemetery), to differentiate it from the newer (though now also over 100 years old) Cementerio Civil de Ponce (Ponce Civil Cemetery). Built in 1842, after the design of Antonio Torruella, the cemetery was enlarged in 1864, following the design of Nieto Blajol Iglesia. It closed in 1918.

Cerro del Vigía is a hill in the municipality of Ponce, Puerto Rico, located just north of the city of Ponce. A tourist destination, it is home to Museo Castillo Serrallés, Cruceta del Vigía, and the former Hotel Ponce Intercontinental. The 456-foot high hill sits at the foothills of the Cordillera Central and is located in Barrio Portugués Urbano. The hill is home to several well-to-do mansions of which the best known is Castillo Serrallés, now a Museum.

Cruceta del Vigía (English: The Watchman Cross) is a 100 feet (30 m) tall cross located atop Cerro del Vigía in Ponce, Puerto Rico, across from Museo Castillo Serrallés. It houses a tourist center at its base, a ten-story vertical tower, and a horizontal sky bridge that has panoramic views of the city of Ponce and the Caribbean Sea. Visitors can reach the skybridge via glass elevators or a staircase. Made of reinforced concrete, the cross has withstood various natural disasters, including three major hurricanes. The arms of the cross measure 70 feet. It was inaugurated in 1984.One of many landmarks of the city of Ponce, the cross is owned by the Municipality of Ponce and is currently operated by the "Patronato de Ponce", a non-profit organization dedicated to preserving the city's cultural heritage. It is visited annually by some 100,000 tourists.

Primero (Barrio Primero) is one of the 31 barrios of the municipality of Ponce, Puerto Rico. Together with Segundo, Tercero, Cuarto, Quinto, and Sexto, Primero is one of the municipality's original six core urban barrios. It was founded in 1878.

Museo Castillo Serrallés (English: Serrallés Castle Museum), a.k.a. Museo de la Caña y el Ron (English: Sugar Cane and Rum Museum), is an agricultural museum in the city of Ponce, Puerto Rico, that showcases the history of sugar cane, its derivative rum industry, and their impact in the economy of Puerto Rico. The most notorious feature of the museum is the building it occupies. The building is a large four-story structure built in the 1930s for the owner of Ponce's Destileria Serralles, one of Puerto Rico's largest rum distilleries. The distillery was once also home to Puerto Rico's largest sugar-factory called Central Mercedita, producers of the Snow White sugar brand. The building, known as Castillo Serrallés, was designed by Pedro Adolfo de Castro in 1930 in the Spanish Colonial Revival style.The museum sits on a 2.5-acre lot and opened on 20 February 1991. Visitors can tour the refurbished home, which has been furnished to appear as it did in the 1930s. There is also a temporary exhibit area for local artists. The Serrallés Castle is now part of a large complex that includes the Cruceta El Vigía, a Japanese Garden, and a butterfly garden (Mariposario). By September 2010, the museum was receiving around 100,000 visitors per year.

Castillo Serrallés (English: Serralles Castle) is a mansion located in the city of Ponce, Puerto Rico, overlooking the downtown area (Ponce Pueblo). It was built during the 1930s for Juan Eugenio Serrallés, son of businessman Juan Serrallés, founder of Destilería Serrallés. The structure sits on a 2.5-acre (1.0 ha) exceedingly manicured property. Nowadays, the structure functions as a museum, Museo Castillo Serrallés, with information about the sugar cane and rum industries and its impact in the economy of Puerto Rico. It is also increasingly used as a venue for social activities, including destination weddings. The property was listed in the National Register of Historic Places in 1980. In 1996, the structure was featured in the American TV series America's Castles.

The Residencia Subirá (Subirá Residence), also known as Residencia Frau (Frau Residence), is a historic building located on Reina Street in Ponce, Puerto Rico, in the city's historic district. The building dates from 1910. It was designed by the architect Blas Silva. The architecture follows the Ponce Creole tradition.