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One Columbia Place, originally named the Columbia Centre, is an office building in San Diego, California. It is the 18th tallest building in San Diego and is a prominent fixture in San Diego's skyline. It is topped by a flagpole flying the largest United States flag in the San Diego skyline.It has a height of 379 ft (116 m) and is located in the Core district of Downtown San Diego. It occupies the full block between West A Street, West B Street, Columbia Street and State Street. It has 27 stories above ground and three below ground. The steel-and-glass building utilizes the modern architectural style and has a six-story atrium. It was built in 1982 by developer Doug Manchester. It was renovated in 1993 and 1997. In 2004 it was designated an Energy Star building.

Columbia is a neighborhood located in Downtown San Diego, California. The neighborhood is largely commercial, however there are many highrise condominium buildings under construction. The Midway Aircraft Carrier Museum and the Maritime Museum are located in this neighborhood.

Anthology was a 13,000 square foot, 325-seat live music venue and fine dining restaurant located at the south end of the Little Italy neighborhood of San Diego, California. It opened in summer 2007 and captured a modern feel of supper clubs of the 1930s and 40s in downtown San Diego. With a cost of over $6.5 million to build, including over $1 million spent on sound engineering, acoustics, and state of the art audio and video equipment, this venue quickly garnered national and international attention, and was considered by many of the Grammy award winning artists that played there to be one of the finest venues in the world to play in. In addition, over 10 Emmy nominations were presented to Anthology during its tenure for its raw footage production of its concerts (see Anthology YouTube videos on Anthology website), an unprecedented occurrence for any music venue in the United States. Anthology closed abruptly in January 2013 because of a divorce between the owners, and was eventually sold to a Los Angeles restaurant and entertainment conglomerate.

Sapphire Tower is the 17th tallest building in San Diego, California and is a prominent fixture in San Diego's skyline. It has a height of 380 ft (116 m) and contains 97 units. Located at the southwest corner of Kettner Boulevard and A Street in the Core district of Downtown San Diego, Sapphire Tower is a 32-story building that utilizes the late-modernist architectural style and was designed by the architect firm Austin Veum Robbins Parshalle.

America Plaza is a station of the Blue and Silver Lines on the San Diego Trolley. It is located in the Downtown Core of San Diego, California, and is directly connected to One America Plaza, the city's tallest building. The station, and its accompanying 34-story high-rise building, opened on November 14, 1991, making the station the second infill station in the San Diego Trolley system.

The YMCA Building in San Diego, California was built in 1924, and added to the National Register of Historic Places in 2007, before the YMCA moved out in 2014. During that time, the group served over 125 million military personnel in the facility. The building now houses the luxury Guild Hotel, a member of the Marriott Tribute Portfolio.

One America Plaza is the tallest building in San Diego, California and a prominent fixture in the waterfront district of the downtown San Diego skyline. The 34-story, 500 ft (150 m), 623,000 sq ft (57,900 m2), obelisk-shaped tower was designed by Helmut Jahn of Murphy/Jahn Architects and KMA Architecture. The top of the building bears a striking resemblance to the end of a Phillips head screwdriver and has a similar appearance to Two Liberty Place in Philadelphia also designed by Jahn, which is a year older. The building is the maximum height permitted by the US Federal Aviation Administration for a structure in downtown San Diego due to its close proximity to San Diego International Airport.One America Plaza was purchased by the real estate development firm, Irvine Company, in February 2006 for US$300 million.The America Plaza San Diego Trolley station is located on the ground floor of the building between the main building and the Museum of Contemporary Art San Diego.The building's elevators are supplied by Mitsubishi Electric and travel at a little over 7 m/s (1400 fpm), making them the fastest in San Diego.

Emerald Plaza is a building in San Diego, California. Tied with The Pinnacle Marina Tower, it has a height of 450 ft (137 m). Located in the Columbia district of Downtown San Diego, Emerald Plaza is a 30-story building with a clustered hexagonal roof, designed by architects C.W. Kim Architects & Planners.

Santa Fe Depot in San Diego, California, is a union station built by the Atchison, Topeka and Santa Fe Railway to replace the small Victorian-style structure erected in 1887 for the California Southern Railroad Company. The Spanish Colonial Revival style station is listed on the National Register of Historic Places and is a San Diego Historic Landmark. Its architecture, particularly the signature twin domes, is often echoed in the design of modern buildings in Downtown San Diego. The historic depot is located in the Core district of Downtown San Diego and is still an active transportation center, providing services to Amtrak intercity trains, Coaster commuter rail trains, the San Diego Trolley, and the San Diego Metropolitan Transit System bus system. The Santa Fe Depot (as it was originally designated) officially opened on March 8, 1915, to accommodate visitors to the Panama-California Exposition. The depot was completed during a particularly optimistic period in the city's development and represents the battle waged by the City of San Diego to become the West Coast terminus of the Santa Fe's transcontinental railroad, a fight that was ultimately lost to the City of Los Angeles. In its heyday, the facility not only handled Santa Fe traffic but also that of the San Diego and Arizona Railway (SD&A) and San Diego Electric Railway (SDERy). The designation was officially changed to "San Diego Union Station" in response to the SD&A's completion of its own transcontinental line in December 1919. Santa Fe resumed solo operation of the station in January 1951 when the San Diego and Arizona Eastern Railway (successor to the SD&A) discontinued passenger service, the SDERy having ceased operation some two years prior. Of the 77 California stations served by Amtrak in Fiscal Year 2017, the Santa Fe Depot was the third busiest in California (behind only Los Angeles Union Station and Sacramento Valley Station) and the 10th busiest in the Amtrak system, boarding or detraining an average of approximately 2,130 passengers daily.

Courthouse is a light rail station in San Diego, California, United States. It is the western terminus of the San Diego Trolley's Orange Line and is located between the Hall of Justice and San Diego Central Courthouse in Downtown San Diego, on C Street between State and Union streets. The station opened on April 29, 2018, after nearly a year of construction.

The Grande at Santa Fe Place is a high-rise residential building in San Diego, California, United States composed of two towers of equal height. The 39-story towers have a height of 420 feet (130 m) and are a prominent fixture in San Diego's skyline. Located in the Core district of Downtown San Diego, The Grande at Santa Fe Place was designed by the architect firm Perkins & Company Architecture and Urban Design Inc. The towers are currently tied with Vantage Pointe Condominium as the tenth-tallest buildings in San Diego.

655 West Broadway (formerly First Allied Plaza, Advanced Equities Plaza and Broadway 655) is the 13th-tallest building in San Diego, California and is a prominent fixture in San Diego's skyline. Tied with the Pinnacle Marina Tower, it has a height of 412 feet (126 m). It is located at 655 West Broadway in the Marina district of Downtown San Diego. 655 West Broadway is a 23-story building that uses the postmodern architectural style and was designed by Carrier Johnson Architects. It is primarily an office building but also contains residential and retail uses.