Rowhouses at 322–344 East 69th Street

The First Hungarian Reformed Church of New York (Hungarian: New York-i Első Magyar Református Egyház) is located on East 69th Street in the Upper East Side of the New York City borough of Manhattan. It is a stucco-faced brick building, completed in 1916 in a Hungarian vernacular architectural style, housing a congregation established in 1895. It is the only Christian religious building designed by Hungarian-born architect Emery Roth, later known for his apartment buildings on Central Park West. As one of two Hungarian Reformed Churches in Manhattan, it has been a focal point for the city's Hungarian-American community since its construction. In 1983, its parsonage was listed on the National Register of Historic Places as a contributing property to the Rowhouses at 322–344 East 69th Street historic district to its immediate west. The parsonage was listed in its own right along with the church in 2000. Following the demolition of the German Evangelical Reformed Church a block to the south, it became the oldest church in the neighborhood.

The Most Serene Federal Republic of Montmartre (or the Serene Republic of Montmartre and Her Dependencies, or in brief the Republic of Montmartre) is either a micronation or an extended political satire. It is mostly within the boundaries of New York City's Manhattan. C. 1965, Barry Alan Richmond (born c. 1933), a stage actor/director, theatrical designer, and theatre promoter, author of articles on the Grand Guignol, proclaimed the Most Serene Federal Republic of Montmartre's existence and borders (mostly within Manhattan's theatre district, "roughly 39th to 59th Street with a strip up the Hudson River to where the boat basin is, and from the middle of Fifth Avenue over to what international laws call the thalweg, which is the navigable channel in the middle of the Hudson River")... but set its origin at 1636. To some extent this may have been a piece of performance art in itself; but it exchanged mutual recognition with other such small organizations (micronations and governments-in-exile), and was acknowledged by the International Micropatrological Society. Richmond is named as its 47th president, among other titles.

Lenox Hill Neighborhood House (the “Neighborhood House”) is a multi-service community-based organization that serves people in need on the East Side of Manhattan and on Roosevelt Island. Founded in 1894 as a free kindergarten for the children of indigent immigrants and as one of the first settlement houses in the nation, Lenox Hill Neighborhood House is the oldest and largest provider of social, legal and educational services on Manhattan's Upper East Side. Each year, they assist thousands of individuals and families who range in age from 3 to 103, represent dozens of races, ethnicities and countries of origin and "live, work, go to school or access services" on the East Side from 14th Street to 143rd Street and on Roosevelt Island. Their clients include indigent families and the working poor who live in the East Side's housing projects and tenements or who travel to the Upper East Side to work in low-wage jobs such as cashiers, housekeepers, nannies and laborers; 10,000 seniors; and hundreds of mentally ill homeless and formerly homeless adults. They have five locations between 54th and 102nd Streets, offer programs at dozens of East Side locations; their headquarters is located on East 70th Street. The Neighborhood House has served the community for 128 years and has multiple departments (Older Adult Services, Children and Family Services, Homelessness and Housing, Food Services, Health and Wellness, Adult Education, Visual and Performing Arts and more), more than 20 different programs, nearly 200 staff and over 1,100 regular volunteers. Their mission is to help those in need who live, work, or go to school on Manhattan's East Side and to improve the quality of life for all individuals and families in their community. They define need broadly to include economic, social, emotional, and physical need, but give priority to those in economic need.

The Julia Richman Education Complex (JREC) is an educational multiplex located in the Upper East Side neighborhood of Manhattan, New York City. Named after the district superintendent of schools, Julia Richman, it houses six autonomous small schools for approximately 1,800 Pre-K through 12th grade students in the former building of Julia Richman High School, a comprehensive high school that operated until 1995. The schools are operated by the New York City Department of Education.

Talent Unlimited High School is a public high school of the performing arts located on the Upper East Side of Manhattan in New York City.

The Urban Academy Laboratory High School (also known as the Urban Academy) is a small, progressive, transfer public high school located on the Upper East Side of New York City. Founded in 1986, its goal was to create a place where students could learn in a nontraditional sense. In 1995, it became one of six small schools located in the Julia Richman Education Complex. The structure of the classes is non-traditional. Teachers don't lecture; rather, they facilitate class discussions. They create their own curriculum and direct students with a focus on inquiry, critical thinking, and problem-solving. Students' primary source of information is not textbooks. Almost all classes are discussion based, with students expected to make arguments and support them with evidence, drawn either from course materials (primary and secondary texts) and/or their own experience. Urban's academic program is rigorous and college-oriented. It has been designated a U.S. Department of Education "Blue Ribbon School of Excellence" and a "New American High School National Showcase Site."As a member school of the New York Performance Standards Consortium, Urban Academy has a waiver from the New York State testing curriculum. Students must pass only the English Language Arts Regents exam, and complete six other performance-based assessments. Students must obtain 44 credits, as in every other public school in New York. Urban Academy does not offer credit recovery, and all students are required to spend a minimum of four semesters at Urban, regardless of the number of credits they enter with (most students spend more than four semesters). The school's six sports teams (Soccer, Volleyball, Basketball; boys and girls teams for each) are composed of students from Urban Academy and the other three high schools housed in the building: Vanguard High School, Talent Unlimited High School, and Manhattan International High School. Urban Academy has a selective admissions process, as one cannot simply enroll through the central New York City Department of Education office.

James Ewing Hospital was a 300-bed Manhattan hospital notable for helping cancer patients. Memorial Sloan Kettering took over running James Ewing Hospital in 1968.

The New York Blood Center (NYBC) is a community, nonprofit blood bank based in New York City. Established in 1964 by Dr. Aaron Kellner, NYBC supplies blood to approximately 200 hospitals in the Northeast United States. NYBC and its operating divisions also provide transfusion-related medical services to over 500 hospitals nationally. NYBC, along with its operating divisions Community Blood Center of Kansas City, Missouri (CBC), Innovative Blood Resources (IBR), Blood Bank of Delmarva (BBD), and Rhode Island Blood Center (RIBC), collect approximately 4,000 units of blood products each day and serve local communities of more than 75 million people in the Tri-State area (NY, NJ, CT), Mid Atlantic area (PA, DE, MD, VA), Missouri and Kansas, Minnesota, Nebraska, Rhode Island, and Southern New England. In addition to serving the New York City metropolitan area, New Jersey, Connecticut and Pennsylvania, in May 2014, NYBC merged its operations with Community Blood Center of Greater Kansas City (CBC). In February 2016, NYBC and CBC announced the creation of the Kansas City-based National Center for Blood Group Genomics, a new laboratory that will focus on precision testing of blood donor samples.NYBC maintains close relationships with both New York City's Police Department (NYPD) and Fire Department (FDNY). Among NYBC's largest donor groups is the NYPD, which donated more than 11,000 pints of blood through November 2015. At the same time, the FDNY participates with NYBC in the "Be The Match Program" operated by the National Marrow Donor Program (NMDP). More than 8,000 FDNY members are on the potential donor list, and 179 members have already given this life saving gift to those in need. FDNY members represent more than 10% of all NYBC bone marrow donors. Each year, at an annual induction ceremony hosted by FDNY and NYBC at FDNY headquarters, donors and their recipients meet for the first time. In 2016, Firefighter Mike Wilson was introduced to a recipient from Erie, Pennsylvania, who received his lifesaving bone marrow to treat her acute myeloid leukemia (AML), while Firefighter Frank Perdue met a recipient diagnosed with essential thrombocythemia, a rare chronic blood disorder. In 2015, firefighter Michael McCauley of Staten Island met his recipient, a United States Marine Sergeant who saw combat in Iraq, and who was subsequently diagnosed with acute myeloid leukemia (AML). Through FDNY’s participation in NYBC’s program, McCauley’s bone marrow is credited with saving the recipient's life.NYBC houses Lindsley F. Kimball Research Institute and the Howard P. Milstein National Cord Blood Center, a public cord blood bank named after board member Howard Milstein. The National Cord Blood Program (NCBP), directed by Dr. Pablo Rubinstein, is the oldest and largest in the world. In August 2015, the NCBP announced a new collaboration with the University of California, Davis Health System to manufacture specialized lines of highly adaptable stem cells for potential new therapies for diseases that include anemia, leukemia, lymphoma, sickle cell disease and severe combined immunodeficiency.The Lindsley F. Kimball Research Institute (LFKRI) has been awarded grants to conduct research in such areas as epidemiology and the development of HIV self-testing interventions, cellular therapy and transfusion medicine, in vitro platelet production, blood genomics, immunology, the development of infectious disease screening techniques and preventions for diseases like severe acute respiratory syndrome, Hepatitis B and Hepatitis C.

The Church of St. Catherine of Siena is a Roman Catholic parish church in the Roman Catholic Archdiocese of New York, located at 411 East 68th Street, Manhattan, New York City. The parish was developed from that of St. Vincent Ferrer in 1896. It is staffed by the Dominican Fathers. The church built a two-story convent and penthouse at 416 East 69th Street, built 1957 to designs by Starrett & Van Vleck of 267 Fifth Avenue for $100,000 ($1,040,000 in current dollar terms).On May 8, 2015, the Archdiocese of New York announced the merger of parishes between St Vincent Ferrer and St. Catherine of Siena Church. Both churches remain open.

The Church of St. John Nepomucene is a Roman Catholic parish located on East 66th Street and 1st Avenue in Manhattan, New York City. The founders of the church were recent immigrants from Slovakia, who began meeting in St. Brigid's Parish at 8th Street and Avenue B in about 1891 and established the Society of St. Matthew to organize their own parish.The parish was established in 1895 from within St. Elizabeth of Hungary parish, which was centered on its church on 83rd Street. The church, school and rectory were built for $300,000.

The Sephardic Academy of Manhattan (SAM) is a Jewish preschool and elementary school on the Upper East Side of Manhattan, New York City, whose plan is to provide pre-K through middle school services. The SAM School’s mission is to provide students with a universal education that emphasizes Sephardic-Judaic Culture and Torah knowledge and observance combined with the study of Sciences, Humanities and the Arts. This unique approach includes the pursuit of rigorous scholastic achievement, embraces a humane approach to learning, cultural recognition and religious humanism. It is rooted in a strong sense of Jewish identity as practiced in Classical Sephardic Heritage.Rabbi Elie Abadie, M.D., started the academy in 2010. The current executive director is Michelle Dayan. The academy is buying the six-story, 11,850-square-foot (1,101 m2) building at 150 East 74th Street, located between Third Avenue and Lexington Avenue in Manhattan and previously the home of the New York Veterinary Hospital, for $14 million. SAM bought the property to expand its programming. The school will open the new location September 2022 and be able to convert it into a school or for a nonprofit use, and will have the option of adding 23,000 square feet (2,100 m2).

The United States Post Office Lenox Hill Station is located at 217 East 70th Street between Second and Third Avenues in the Lenox Hill neighborhood of the Upper East Side, Manhattan, New York City. It is a brick building constructed in 1935 and designed by Eric Kebbon in the Colonial Revival style, and is considered one of the finest post offices in that style in New York State. It was listed on the National Register of Historic Places in 1989, along with many other post offices in the state.