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The Harrisburg Transportation Center (HTC, formerly Pennsylvania Station, Harrisburg or Harrisburg Central Railroad Station) is a railway station and transportation hub in Harrisburg, Pennsylvania. It is located on the eastern edge of Downtown Harrisburg between the intersections of Aberdeen and Market Streets and 4th and Chestnut Streets. The well-situated station is the primary hub for passenger rail and intercity bus services in the Harrisburg metropolitan area and South Central Pennsylvania.

William Seel Building is a historic commercial building located at Harrisburg, Dauphin County, Pennsylvania. It was built in 1912–1913, and is a narrow four-story, four bay wide office building built of brownstone and brick. It features two elegant arches at the first floor and an overhanging cornice.It was added to the National Register of Historic Places in 1980.

Harrisburg University of Science & Technology, commonly referred to as Harrisburg University (HU), is a private STEM-focused university in Harrisburg, Pennsylvania, with an additional location in Philadelphia. Founded in 2001 as Harrisburg Polytechnic Institute, it offers STEM-focused degree and certificate programs. Harrisburg University places special emphasis on education in fields related to engineering, applied science and technology and offers 15 bachelor's degrees, 13 master's degrees, and 3 doctoral degrees and certificate programs. The university is accredited by the Middle States Commission on Higher Education.

Harrisburg Technical High School, also known as Old City Hall, is a historic building and former high school located in Harrisburg, Dauphin County, Pennsylvania. Though previously used as a high school, vocational school, and municipal building, it is now converted for apartments. It was added to the National Register of Historic Places in 1982.

Harris Switch Tower, also known as HG Tower or Harris Tower, is an interlocking tower in Harrisburg, Pennsylvania in the United States. The tower was built in 1929 by the Pennsylvania Railroad and remained in operation until it was closed in 1991 by Amtrak. Harris was purchased by the local chapter of the National Railway Historical Society in 1992 and listed on the National Register of Historic Places in 1994.

Old Downtown Harrisburg Commercial Historic District is a national historic district located at Harrisburg, Dauphin County, Pennsylvania. The district includes 50 contributing buildings in the old central business district of Harrisburg and dating from the late-19th and early-20th centuries. Notable buildings include the Daily and Weekly Telegraph Building (1873-1874), City Bank Building (c. 1872), F.W. Woolworth (1939), Rothert's Furniture Store (1906), Bowman's Department Store (1907, 1910), Pomeroy's Department Store (c. 1890, c. 1940), and Doutrich's Clothing Store. Located in the district and listed separately are the Colonial Theatre, Keystone Building, Kunkel Building, and the William Seel Building. The Telegraph Building was delisted after having been demolished. It was added to the National Register of Historic Places in 1983, with a boundary increase in 1984.

The Mulberry Street Bridge is a concrete arch bridge that spans Cameron Street and Paxton Creek in Harrisburg, Pennsylvania. The bridge is the second constructed at the current site to connect the Allison Hill neighborhood of East Harrisburg to Downtown. It replaced an iron and fire-prone, wood-decked structure erected in 1891, which was heralded as a unifier of a "Greater Harrisburg". The concrete replacement bridge constructed in 1909, was a marvel at the time, and is eligible to be listed on the National Register of Historic Places.

SoMa, or South of Market Street, is a neighborhood in Downtown Harrisburg, Pennsylvania around South Third Street, bounded by Market to the north, 3rd to the west, Chestnut to the south, and 4th to the east. The name "SoMa" derives from the area being "South of Market Street", coined by Harristown Enterprises in 2007 to rebrand the South Third Street area for new development relating to international business and the arts. Eight restored historic buildings became 20 apartments branded as "SoMa on Third". The area is a popular housing area for students attending the nearby Harrisburg University. The area contains popular retail and bar & restaurant destinations and hosts frequent block parties in which they participate with other incoming vendors and entertainment.

Strawberry Square is a mixed-use retail and commercial complex located in downtown Harrisburg, Pennsylvania. It is owned and managed by the Harristown Development Corporation (HDC), a non-profit organization.

Keystone Building is a historic commercial building located at Harrisburg, Dauphin County, Pennsylvania. It was built in 1875 as the State Printing Office. It is a six-story office building, plus basement, 7 bays wide and 12 bays deep. It is faced in granite on the first floor, with brick above. It was remodeled in 1917, with the addition of a structural steel frame and 12-inch reinforced floors.It was added to the National Register of Historic Places in 1979.This building is not to be confused with the Commonwealth Keystone Building, a nearby State Government office building completed in 2000.

Salem United Church of Christ, formerly known as Old Salem Reformed Church, is a historic Reformed church at 231 Chestnut Street in Harrisburg, Dauphin County, Pennsylvania. The church was built in 1821–1822, and is a two-story brick building in a Classical style. It features a large square bell tower topped by a domed cupola. The tower is flanked by two, three-story towers with stepped gables. A two-story, Sunday school annex was built to the rear of the church in 1862.It was added to the National Register of Historic Places in 1975.

Camp Curtin Memorial Methodist Episcopal Church, also known as Curtin Heights Church and Camp Curtin Memorial-Mitchell United Methodist Church, is a historic Methodist Episcopal church located in Harrisburg, Dauphin County, Pennsylvania.It was added to the National Register of Historic Places in 2010. The Susquehanna Conference of the United Methodist Church announced plans, in December 2018, to consolidate or sell roughly 10 churches in the greater Harrisburg area. In February 2021, newspapers reported that Camp Curtin Memorial-Mitchell United Methodist Church would be sold "to a church off of the west coast that is buying it as a church for veterans," and that "a veterans' ministry" would be established at the historic church; however, the realtor involved in the transaction reported a month later that the church was "back on the market" because the deal had fallen through. News accounts at the time noted that the realtor's most recent listing stated that the "15,852-square-foot property [was] listed for $155K," and that the church was] zoned 'commercial neighborhood,' which provides the possibility of a number of uses for the property."