E. & B. Holmes Machinery Company Building

Buffalo RiverWorks is a multipurpose indoor venue and restaurant located on the shore of the Buffalo River in Buffalo, New York.

The Great Northern Elevator is a grain storage facility at 250 Ganson Street in Buffalo, New York. The elevator is located along Buffalo's "elevator alley" and at the time of its completion in 1897, the elevator was the world's largest. The mill was also one of the first to run on electricity.

DL&W station is a Buffalo Metro Rail light rail indoor station currently under construction. It is planned for the first floor on the Buffalo River side of the former Delaware, Lackawanna and Western Railroad terminal, which currently serves as the NFTA Rail Maintenance Yard. This station will eliminate the Special Events station and provide commuters access to parking and Metro Rail service to the city, and a direct pedestrian walkway to Canalside areas.

The Metro Rail Maintenance Yard or "South Park Terminal" houses Buffalo Metro Rail's cars in a train shed at the former Delaware, Lackawanna and Western Railroad terminal in the Cobblestone District of Buffalo, New York. The property is located at the southernmost fringe of the Central Business District. The station was built in 1917, and was designed to handle both steam trains and steamships. The storage and maintenance facility was converted to its present condition in 1982, following the demolition of the former main terminal concourse building "headhouse" of the DL&W Terminal in 1979. The lower level of the sheds are used to store the rail cars when they are not in use. The upper level is mostly empty space, consisting of the concrete troughs where tracks once stood and their platforms. However, some of it is used for offices, a train operators' lounge and storage. Numerous proposals for adaptive reuse of the unused portion of the upper level of the terminal sheds have been floated publicly by various parties, including: a casino, a farmers market and loft apartments, while the lower floor is currently undergoing reconstruction to accommodate a new Metro Rail station. In 1982, an addition was built on the east end of the terminal building, which has a modern rail maintenance shop for servicing the rail fleet. This addition also contains some administrative offices.

KeyBank Center is a multipurpose indoor arena located in Buffalo, New York. Originally known as Marine Midland Arena, the venue has since been named HSBC Arena and First Niagara Center. Home to the Buffalo Sabres of the National Hockey League since 1996, is the largest indoor arena in Western New York, seating 19,070. It replaced the Sabres' former home, Buffalo Memorial Auditorium, where the team played from 1970 to 1996. The venue is also home to the Buffalo Bandits of the National Lacrosse League. KeyBank Center was previously home to the Canisius Golden Griffins (NCAA), Buffalo Blizzard (NPSL), Buffalo Wings (RHI) and Buffalo Destroyers (AFL). In addition to concerts and professional wrestling, the venue has hosted major events including the NCAA Division I Men's Basketball Tournament, 1999 Stanley Cup Finals, 2003 Frozen Four and UFC 210.

American Grain Complex, also known as "The American," Russell-Miller Milling Co. Elevator, and Peavey Co. Elevator, is a historic grain elevator and flour milling complex located in South Buffalo, Buffalo, Erie County, New York. The complex consists of three contributing buildings and two contributing structures. They are the Elevator Building (1905/1906, 1931), Flour Building (1906-1924), office building (c. 1920), Moveable Marine Tower, and railroad tracks. The Elevator Building consists of the mainhouse, workhouse, and fixed marine tower, all built in 1905–1906, and an annex constructed in 1931. The complex was last owned by ConAgra Foods, who closed the elevator and mill in June 2001.It was listed on the National Register of Historic Places in 2012.

Buffalo–Exchange Street station is an Amtrak station in Buffalo, New York. The station serves six Amtrak trains daily: two daily Empire Service round trips between Niagara Falls and New York City and one Maple Leaf round trip between Toronto and New York City. There is also daily Amtrak Thruway bus service (operated by Coach USA) at the station, operating between the Buffalo Metropolitan Transportation Center and Jamestown station in Jamestown, New York, via Dunkirk and Fredonia, and serving the communities along the southeast shore of Lake Erie.Local transportation is provided by the Niagara Frontier Transportation Authority (NFTA), which operates buses and the Buffalo Metro Rail. Buffalo–Exchange Street is located close to Metro Rail's Erie Canal Harbor station and the two stations are connected by a lit pathway beneath Interstate 190 with decorative cement and signage. The station is close to the KeyBank Center and Sahlen Field. The station has one high-level side platform on the north side of two tracks. It is one of two stations in the Buffalo area, the other being Buffalo–Depew station which serves the Lake Shore Limited. The current station is the fifth train station to be built at the current site, it was opened in 2020.

The Helene Fuld Health Trust is the largest charitable trust in the United States devoted exclusively to supporting student nurses and nursing education. The trust — which began as a foundation in 1935, but transferred its assets to the trust in 1969 — has provided grants, scholarships, and financial aid for the education, health, and welfare of student nurses.

LECOM Harborcenter is an American mixed-use development in Buffalo, New York developed by Pegula Sports and Entertainment. The building occupies a full 1.7 acre city block formerly known as the Webster Block, directly across from and connected to the KeyBank Center and Canalside. The building is also near the southern terminus of the Erie Canal Harbor (Metro Rail) station. The development features retail and restaurant space, a 205-room Buffalo Marriott Harborcenter Hotel, as well as two hockey rinks that are the home of the Buffalo Jr. Sabres of the Ontario Junior Hockey League, the Canisius Golden Griffins of the NCAA, and the Erie Kats of the National Junior College Athletic Association. The rinks are also the Buffalo Sabres practice facility.

Sibley and Holmwood Candy Factory and Witkop and Holmes Headquarters, also known as the Weed & Company Building, are two connected historic commercial buildings located in downtown Buffalo, Erie County, New York. The Sibley & Holmwood Candy Factory (149 Swan Street) was built in 1896 and is a five-story, nine-bay-wide brick commercial block with late-Gothic detailing. It features Gothic window arches, decorative cast-iron columns on the storefront, and corbelled cornice. The Witkop & Holmes Headquarters (145 Swan Street) was designed by the architectural firm Bethune, Bethune & Fuchs and built in 1901. It is a four-story, three-bay-wide brick commercial block. Both buildings have flat roofs. The building has been renovated to house loft apartments. It was listed on the National Register of Historic Places in 2014.

The Lehigh Valley Terminal was a railroad station in downtown Buffalo, New York. The Lehigh Valley Railroad opened it in 1916, replacing an older station one block east at Scott and Washington streets. Lehigh Valley trains served at the station included the Black Diamond, Maple Leaf and Star. The station handled the Lehigh Valley's passenger traffic in Buffalo until 1955, when it was demolished to make room for the Niagara Thruway (Interstate 190). The Lehigh Valley moved its operations to a smaller station outside the downtown area at Dingens and South Ogden Streets, which served until the end of all Lehigh Valley passenger service in 1961. The terminal also hosted the Erie Railroad's passenger trains from 1935 until 1951, when that railroad ceased serving Buffalo.

SS Columbia is the last remaining excursion steamship from the turn of the 20th century in existence, the second to last being her running mate and sister ship SS Ste. Claire which burned in 2018. Both were designed by Frank E. Kirby and Louis O. Keil. Columbia was listed on the National Register of Historic Places in 1979, and was designated a National Historic Landmark in 1992. As of 2019, the vessel is docked at Silo City in Buffalo, New York while work is being done to rehabilitate it.