Sibley and Holmwood Candy Factory and Witkop and Holmes Headquarters

Burt Flickinger Center is a multipurpose indoor venue located in downtown Buffalo, New York.The venue is named after Burt Prentice Flickinger, Jr., an heir to the S.M. Flickinger food distribution company who spearheaded efforts to bring the 1993 World University Games to Buffalo.The venue was originally constructed for the 1993 World University Games and is now used full-time by the Erie Kats, SUNY Erie's athletic program. The facility contains a field house that seats 3,200 and an Olympic-sized swimming pool that seats 1,500.The venue hosted several professional wrestling shows from the ECW promotion between 1997 and 2000, including November to Remember 1999. Joe Mesi defeated Anthony Green to win the New York State Heavyweight Championship during a professional boxing card at the venue in 1999.The venue was formerly home to the Buffalo Rapids of the American Basketball Association in 2005 and the Buffalo 716ers of the American Basketball Association in 2015. The venue has been the home of Canisius Golden Griffins swimming and diving meets since 2011.

Alling & Cory Buffalo Warehouse is a historic warehouse building located at Buffalo in Erie County, New York. It consists of a six-story, "L" shaped, 120,000-square-foot (11,000 m2) former paper warehouse building built in 1910-1911 for the Alling & Cory company of Rochester, with a one-story, brick loading dock addition built in 1926. It is built of reinforced concrete with classical detailing and considered to be of the "Daylight Factory" design. The building has been rehabilitated into an apartment complex.It was listed on the National Register of Historic Places in 2010.

The Old Post Office, also known as U.S. Post Office, is a historic post office building located at 121 Ellicott Street in Buffalo in Erie County, New York.

The Buffalo Metropolitan Transportation Center is located on the southeast corner of North Division and Ellicott Streets in Downtown Buffalo, New York. The transportation center is open 24 hours daily. Managed by the Niagara Frontier Transportation Authority (NFTA), which also uses the transit center as its headquarters, it operates as a major transportation hub for a number of NFTA Metro bus routes, as well as inter-city bus services. Its location is also of importance in that this terminal normally is the first or last stop in the United States on the busy Toronto-New York City bus corridor in the United States (the exceptions being a re-routed Buffalo to Toronto runs serving Buffalo Niagara International Airport on the way to the Rainbow Bridge, where it crosses into Ontario). The closest two Canadian bus stations (though not served by all trips) are Fort Erie (located at a Robomart gas station at 22 Princess Street, at Waterloo Street) or the more frequently served Niagara Falls Transit Terminal at Bridge and Erie Streets in downtown Niagara Falls, Ontario. Built in 1977, the architectural firm of CannonDesign created a terminal that is a "pleasant and even exciting space to experience, with views of travelers, buses and the city beyond afforded by comparatively large areas of glazing". It replaced an older Greyhound Station, located at 672 Main Street, near Tupper. After the Main Street station had closed, it became a police station for the Buffalo Theater District, and is currently used partially as the Alleyway Theatre

Durham Memorial A.M.E. Zion Church, formerly known as St. Luke's A.M.E. Zion Church until the late 1950s, is a historic African Methodist Episcopal Zion Church located at Buffalo in Erie County, New York. It is a brick church constructed in 1920. It is the oldest surviving church associated with the Buffalo A.M.E. Zion congregations.It was listed on the National Register of Historic Places in 1983.

Sahlen Field is a baseball park in Buffalo, New York, United States. Originally known as Pilot Field, the venue has since been named Downtown Ballpark, North AmeriCare Park, Dunn Tire Park, and Coca-Cola Field. Home to the Buffalo Bisons of the International League, it opened on April 14, 1988 and can seat up to 16,600 people, making it the highest-capacity Triple-A ballpark in the United States. It replaced the Bisons' former home, War Memorial Stadium, where the team played from 1979 to 1987. The stadium was the first retro-classic ballpark built in the world, and was designed with plans for Major League Baseball (MLB) expansion. Buffalo had not had an MLB team since the Buffalo Blues played for the Federal League in 1915. However, Bisons owner Robert E. Rich Jr. was unsuccessful in his efforts to bring an MLB franchise to the stadium between 1988 and 1995. The stadium was a temporary home to the Toronto Blue Jays of MLB in 2020 and 2021 when they were displaced by the COVID-19 pandemic. Sahlen Field was previously home to the Buffalo Nighthawks of the Ladies Professional Baseball League in 1998, the Buffalo Bulls of the National Collegiate Athletic Association in 2000, and the Empire State Yankees of the International League in 2012. In addition to concerts and professional wrestling, the stadium has hosted major events including the National Old-Timers Baseball Classic (1988–1990), Triple-A All-Star Game (1988, 2012), StarGaze (1992–1993), World University Games (1993) and National Buffalo Wing Festival (2002–2019).

Buffalo–Exchange Street station is an Amtrak station in Buffalo, New York. The station serves six Amtrak trains daily: two daily Empire Service round trips between Niagara Falls and New York City and one Maple Leaf round trip between Toronto and New York City. There is also daily Amtrak Thruway bus service (operated by Coach USA) at the station, operating between the Buffalo Metropolitan Transportation Center and Jamestown station in Jamestown, New York, via Dunkirk and Fredonia, and serving the communities along the southeast shore of Lake Erie.Local transportation is provided by the Niagara Frontier Transportation Authority (NFTA), which operates buses and the Buffalo Metro Rail. Buffalo–Exchange Street is located close to Metro Rail's Erie Canal Harbor station and the two stations are connected by a lit pathway beneath Interstate 190 with decorative cement and signage. The station is close to the KeyBank Center and Sahlen Field. The station has one high-level side platform on the north side of two tracks. It is one of two stations in the Buffalo area, the other being Buffalo–Depew station which serves the Lake Shore Limited. The current station is the fifth train station to be built at the current site, it was opened in 2020.

Hotel Lafayette, also known as the Lafayette Hotel, is a historic hotel building located at Buffalo in Erie County, New York.

E.M. Hager & Sons Company Building is a historic planing mill located in downtown Buffalo, Erie County, New York. The main section was built in 1878 and is a three-story brick building. Two-story additions were made to the main block about 1880, and a three-story wing about 1920. It features brick corbelling and segmental arched openings. E.M. Hager & Sons Company remained in operation until the 1980s, after which the building was converted to a restaurant (the Spaghetti Warehouse) and night club.It was listed on the National Register of Historic Places in 2013.

J. N. Adam–AM&A Historic District is a national historic district located at Buffalo in Erie County, New York. The district resulted from the agglomeration of commercial structures over many years of commercial growth and still reflects conscious decisions made by the original planners of the J. N. Adam & Co., and later AM&A's department stores. The main department store was designed by Starrett & van Vleck and built in 1935, with additions made in 1946–1948. The service building and entrances date to 1909 and is a six-story, brick flat roofed commercial structure. Two six story, brick commercial structures fronting on Washington Street were designed by Green & Wicks in the 1890s. A five-story steel frame warehouse building fronting on Washington Street dates to 1911–1912. Connected to it are a warehouse building dating to 1882, one dating to 1906–1907, and one fronting on Ellicott Street and dating to 1912–1913.Plans announced in January 2010 are for the complex to be converted to apartments and offices.It was listed on the National Register of Historic Places in 2009.

The Ellicott Square Building is a historic office complex, completed in 1896, located in Buffalo, New York.

One M&T Plaza is an office tower located in Buffalo, New York and home to M&T Bank in Erie County. The 21-story International style or New Formalist office tower was designed by Minoru Yamasaki with Duane Lyman Associates and completed in 1967. The structural steel for the building was produced locally by Bethlehem Steel, and was a product of their V50 grade. The base of the building is composed of white and green marble with an interior of travertine. The building also features a 75-by-225 foot exterior plaza.