LECOM Harborcenter

The Helene Fuld Health Trust is the largest charitable trust in the United States devoted exclusively to supporting student nurses and nursing education. The trust — which began as a foundation in 1935, but transferred its assets to the trust in 1969 — has provided grants, scholarships, and financial aid for the education, health, and welfare of student nurses.

Erie Canal Harbor (formerly Auditorium until September 1, 2003) is a Buffalo Metro Rail station located in the 100 block of Main Street (just north of Hanover and Scott Streets) next to the South Aud Block of Canalside in the Free Fare Zone, which allows passengers free travel between this station and Fountain Plaza station. Passengers continuing past Fountain Plaza are required to provide proof-of-payment. Unless there are events occurring at KeyBank Center, in which case Special Events station will be utilized, this is the southern terminus of Metro Rail. Since Erie Canal Harbor station serves as a terminal, immediately north is a double crossover. Erie Canal Harbor station is located close to Amtrak's Buffalo–Exchange Street station and the two stations are connected by a lit pathway beneath Interstate 190 with decorative cement and signage.

The Lehigh Valley Terminal was a railroad station in downtown Buffalo, New York. The Lehigh Valley Railroad opened it in 1916, replacing an older station one block east at Scott and Washington streets. Lehigh Valley trains served at the station included the Black Diamond, Maple Leaf and Star. The station handled the Lehigh Valley's passenger traffic in Buffalo until 1955, when it was demolished to make room for the Niagara Thruway (Interstate 190). The Lehigh Valley moved its operations to a smaller station outside the downtown area at Dingens and South Ogden Streets, which served until the end of all Lehigh Valley passenger service in 1961. The terminal also hosted the Erie Railroad's passenger trains from 1935 until 1951, when that railroad ceased serving Buffalo.

Buffalo Memorial Auditorium, colloquially known as The Aud, was a multipurpose indoor arena in downtown Buffalo, New York. Opened on October 14, 1940, it was home to the Canisius Golden Griffins (NCAA), the Buffalo Bisons (AHL), the Buffalo Bisons (NBL), the Buffalo Braves (NBA), the Buffalo Sabres (NHL), the Toronto-Buffalo Royals (WTT), the Buffalo Stallions (MSL), the Buffalo Bandits (MILL), the Buffalo Blizzard (NPSL) and the Buffalo Stampede (RHI). It also hosted events such as college basketball, concerts, professional wrestling and boxing. The venue was closed in 1996 after the construction of Marine Midland Arena, and remained vacant until being demolished in 2009.

KeyBank Center is a multipurpose indoor arena located in Buffalo, New York. Originally known as Marine Midland Arena, the venue has since been named HSBC Arena and First Niagara Center. Home to the Buffalo Sabres of the National Hockey League since 1996, is the largest indoor arena in Western New York, seating 19,070. It replaced the Sabres' former home, Buffalo Memorial Auditorium, where the team played from 1970 to 1996. The venue is also home to the Buffalo Bandits of the National Lacrosse League. KeyBank Center was previously home to the Canisius Golden Griffins (NCAA), Buffalo Blizzard (NPSL), Buffalo Wings (RHI) and Buffalo Destroyers (AFL). In addition to concerts and professional wrestling, the venue has hosted major events including the NCAA Division I Men's Basketball Tournament, 1999 Stanley Cup Finals, 2003 Frozen Four and UFC 210.

Explore & More - The Ralph C. Wilson, Jr. Children's Museum is a museum in Buffalo, New York. The museum is for and about Buffalo - with seven play zones and three educational studios that are used to tell the unique story of Western New York. Designed for children from birth - 12 years of age, these hands-on play zones encourage children to explore their interests through the power of play. It was founded in 1994 in East Aurora, New York. In 2019, the museum moved from East Aurora to the Canalside district of Buffalo. Many of the former exhibits from the East Aurora location were donated to the Children's Activity Corner of Jamestown. On February 14, 2018, the Ralph C. Wilson Jr. Foundation awarded a $6 million grant to the museum and the then-under construction Canalside museum was re-named in honor of Wilson.The museum is located at 130 Main St. Buffalo, NY 14202.

Seneca One Tower is a skyscraper located in downtown Buffalo, New York. The building was formerly known as One HSBC Center (1999–2013) and prior to that, as Marine Midland Center (1972–1999), its name was changed in 1999 shortly after Marine Midland's parent company HSBC re-branded the bank as HSBC Bank USA. The building was constructed at a cost of $50 million between 1969 and 1974, and contains over 1,200,000 square feet (110,000 m2) of space. Today, the 40 story building still dominates the Buffalo skyline, at 529 feet (161 m) high. It is an example of modern architecture. The building's design is similar to that of the 33 South Sixth building in Minneapolis, reason being that both buildings were designed by the same architectural firm. In 2021, the entire tower and 4 mezzanine floors were finished being renovated as part of a $150 million renovation by Douglas Development, which included adding over 200 prime rate apartments.

Buffalo–Exchange Street station is an Amtrak station in Buffalo, New York. The station serves six Amtrak trains daily: two daily Empire Service round trips between Niagara Falls and New York City and one Maple Leaf round trip between Toronto and New York City. There is also daily Amtrak Thruway bus service (operated by Coach USA) at the station, operating between the Buffalo Metropolitan Transportation Center and Jamestown station in Jamestown, New York, via Dunkirk and Fredonia, and serving the communities along the southeast shore of Lake Erie.Local transportation is provided by the Niagara Frontier Transportation Authority (NFTA), which operates buses and the Buffalo Metro Rail. Buffalo–Exchange Street is located close to Metro Rail's Erie Canal Harbor station and the two stations are connected by a lit pathway beneath Interstate 190 with decorative cement and signage. The station is close to the KeyBank Center and Sahlen Field. The station has one high-level side platform on the north side of two tracks. It is one of two stations in the Buffalo area, the other being Buffalo–Depew station which serves the Lake Shore Limited. The current station is the fifth train station to be built at the current site, it was opened in 2020.

USS The Sullivans (DD-537) is a retired United States Navy Fletcher-class destroyer. The ship was named in honor of the five Sullivan brothers (George, Francis, Joseph, Madison, and Albert) aged 20 to 27 who lost their lives when their ship, USS Juneau, was sunk by a Japanese submarine during the Naval Battle of Guadalcanal on 13 November 1942. This was the greatest military loss by any one American family during World War II. She was also the first ship commissioned in the Navy that honored more than one person. After service in both World War II and the Korean War, The Sullivans was assigned to the 6th Fleet and was a training ship until she was decommissioned on 7 January 1965. In 1977, she and cruiser USS Little Rock were processed for donation to the Buffalo and Erie County Naval & Military Park in Buffalo, New York. The ship now serves as a memorial museum ship and is open for public tours. On 13 April 2022, the USS The Sullivans partially sank from a severe hull breach.

The Marin, previously the Main Seneca Building, and originally known as the Marine Midland Trust Company Building or the "Marine Trust Building," is a 17-story Renaissance Revival style highrise in downtown Buffalo, New York. The building was previously the headquarters for Marine Midland Bank before the bank constructed One Marine Midland Center at 1 Seneca Tower, the tallest building in Buffalo.

USS Little Rock (CL-92/CLG-4/CG-4) is a Cleveland-class light cruiser and one of 27 completed for the United States Navy during or shortly after World War II. She is one of six to be converted to guided missile cruisers and the first US Navy ship to be named for Little Rock, Arkansas. Commissioned in mid-1945, she was completed too late to see combat duty during World War II and was retired post-war, becoming part of the Atlantic Reserve Fleet in 1949. In the late 1950s, she was converted to a Galveston-class guided-missile cruiser, removing her aft six-inch and five-inch guns to accommodate the Talos missile system. Like three other of her sister Cleveland ships converted to missile ships, she was also extensively modified forward to become a flagship. This involved removal of most of her forward armament to allow for an enlarged superstructure and was recommissioned in 1960 as CLG-4 (redesignated CG-4 in 1975). In this configuration, she served in the Mediterranean, often as the Sixth Fleet flagship. She decommissioned for the final time in 1976 and is now a museum ship, located in Buffalo, New York.

The Buffalo and Erie County Naval & Military Park, formerly known as The Buffalo Naval and Servicemen's Park, is a museum on the bank of the Buffalo River in Buffalo, New York. It is home to several decommissioned US Naval vessels, including the Cleveland-class cruiser USS Little Rock, the Fletcher-class destroyer USS The Sullivans, and the submarine USS Croaker. All three are open to the public for tours.