KeyBank Center

The Helene Fuld Health Trust is the largest charitable trust in the United States devoted exclusively to supporting student nurses and nursing education. The trust — which began as a foundation in 1935, but transferred its assets to the trust in 1969 — has provided grants, scholarships, and financial aid for the education, health, and welfare of student nurses.

LECOM Harborcenter is an American mixed-use development in Buffalo, New York developed by Pegula Sports and Entertainment. The building occupies a full 1.7 acre city block formerly known as the Webster Block, directly across from and connected to the KeyBank Center and Canalside. The building is also near the southern terminus of the Erie Canal Harbor (Metro Rail) station. The development features retail and restaurant space, a 205-room Buffalo Marriott Harborcenter Hotel, as well as two hockey rinks that are the home of the Buffalo Jr. Sabres of the Ontario Junior Hockey League, the Canisius Golden Griffins of the NCAA, and the Erie Kats of the National Junior College Athletic Association. The rinks are also the Buffalo Sabres practice facility.

The Lehigh Valley Terminal was a railroad station in downtown Buffalo, New York. The Lehigh Valley Railroad opened it in 1916, replacing an older station one block east at Scott and Washington streets. Lehigh Valley trains served at the station included the Black Diamond, Maple Leaf and Star. The station handled the Lehigh Valley's passenger traffic in Buffalo until 1955, when it was demolished to make room for the Niagara Thruway (Interstate 190). The Lehigh Valley moved its operations to a smaller station outside the downtown area at Dingens and South Ogden Streets, which served until the end of all Lehigh Valley passenger service in 1961. The terminal also hosted the Erie Railroad's passenger trains from 1935 until 1951, when that railroad ceased serving Buffalo.

Erie Canal Harbor (formerly Auditorium until September 1, 2003) is a Buffalo Metro Rail station located in the 100 block of Main Street (just north of Hanover and Scott Streets) next to the South Aud Block of Canalside in the Free Fare Zone, which allows passengers free travel between this station and Fountain Plaza station. Passengers continuing past Fountain Plaza are required to provide proof-of-payment. Unless there are events occurring at KeyBank Center, in which case Special Events station will be utilized, this is the southern terminus of Metro Rail. Since Erie Canal Harbor station serves as a terminal, immediately north is a double crossover. Erie Canal Harbor station is located close to Amtrak's Buffalo–Exchange Street station and the two stations are connected by a lit pathway beneath Interstate 190 with decorative cement and signage.

DL&W station is a Buffalo Metro Rail light rail indoor station currently under construction. It is planned for the first floor on the Buffalo River side of the former Delaware, Lackawanna and Western Railroad terminal, which currently serves as the NFTA Rail Maintenance Yard. This station will eliminate the Special Events station and provide commuters access to parking and Metro Rail service to the city, and a direct pedestrian walkway to Canalside areas.

The Metro Rail Maintenance Yard or "South Park Terminal" houses Buffalo Metro Rail's cars in a train shed at the former Delaware, Lackawanna and Western Railroad terminal in the Cobblestone District of Buffalo, New York. The property is located at the southernmost fringe of the Central Business District. The station was built in 1917, and was designed to handle both steam trains and steamships. The storage and maintenance facility was converted to its present condition in 1982, following the demolition of the former main terminal concourse building "headhouse" of the DL&W Terminal in 1979. The lower level of the sheds are used to store the rail cars when they are not in use. The upper level is mostly empty space, consisting of the concrete troughs where tracks once stood and their platforms. However, some of it is used for offices, a train operators' lounge and storage. Numerous proposals for adaptive reuse of the unused portion of the upper level of the terminal sheds have been floated publicly by various parties, including: a casino, a farmers market and loft apartments, while the lower floor is currently undergoing reconstruction to accommodate a new Metro Rail station. In 1982, an addition was built on the east end of the terminal building, which has a modern rail maintenance shop for servicing the rail fleet. This addition also contains some administrative offices.

Buffalo Memorial Auditorium, colloquially known as The Aud, was a multipurpose indoor arena in downtown Buffalo, New York. Opened on October 14, 1940, it was home to the Canisius Golden Griffins (NCAA), the Buffalo Bisons (AHL), the Buffalo Bisons (NBL), the Buffalo Braves (NBA), the Buffalo Sabres (NHL), the Toronto-Buffalo Royals (WTT), the Buffalo Stallions (MSL), the Buffalo Bandits (MILL), the Buffalo Blizzard (NPSL) and the Buffalo Stampede (RHI). It also hosted events such as college basketball, concerts, professional wrestling and boxing. The venue was closed in 1996 after the construction of Marine Midland Arena, and remained vacant until being demolished in 2009.

Explore & More - The Ralph C. Wilson, Jr. Children's Museum is a museum in Buffalo, New York. The museum is for and about Buffalo - with seven play zones and three educational studios that are used to tell the unique story of Western New York. Designed for children from birth - 12 years of age, these hands-on play zones encourage children to explore their interests through the power of play. It was founded in 1994 in East Aurora, New York. In 2019, the museum moved from East Aurora to the Canalside district of Buffalo. Many of the former exhibits from the East Aurora location were donated to the Children's Activity Corner of Jamestown. On February 14, 2018, the Ralph C. Wilson Jr. Foundation awarded a $6 million grant to the museum and the then-under construction Canalside museum was re-named in honor of Wilson.The museum is located at 130 Main St. Buffalo, NY 14202.

Buffalo–Exchange Street station is an Amtrak station in Buffalo, New York. The station serves six Amtrak trains daily: two daily Empire Service round trips between Niagara Falls and New York City and one Maple Leaf round trip between Toronto and New York City. There is also daily Amtrak Thruway bus service (operated by Coach USA) at the station, operating between the Buffalo Metropolitan Transportation Center and Jamestown station in Jamestown, New York, via Dunkirk and Fredonia, and serving the communities along the southeast shore of Lake Erie.Local transportation is provided by the Niagara Frontier Transportation Authority (NFTA), which operates buses and the Buffalo Metro Rail. Buffalo–Exchange Street is located close to Metro Rail's Erie Canal Harbor station and the two stations are connected by a lit pathway beneath Interstate 190 with decorative cement and signage. The station is close to the KeyBank Center and Sahlen Field. The station has one high-level side platform on the north side of two tracks. It is one of two stations in the Buffalo area, the other being Buffalo–Depew station which serves the Lake Shore Limited. The current station is the fifth train station to be built at the current site, it was opened in 2020.

Seneca One Tower is a skyscraper located in downtown Buffalo, New York. The building was formerly known as One HSBC Center (1999–2013) and prior to that, as Marine Midland Center (1972–1999), its name was changed in 1999 shortly after Marine Midland's parent company HSBC re-branded the bank as HSBC Bank USA. The building was constructed at a cost of $50 million between 1969 and 1974, and contains over 1,200,000 square feet (110,000 m2) of space. Today, the 40 story building still dominates the Buffalo skyline, at 529 feet (161 m) high. It is an example of modern architecture. The building's design is similar to that of the 33 South Sixth building in Minneapolis, reason being that both buildings were designed by the same architectural firm. In 2021, the entire tower and 4 mezzanine floors were finished being renovated as part of a $150 million renovation by Douglas Development, which included adding over 200 prime rate apartments.

Clara Brown, also known as John G. Alden Design No. 872, is a historic racing sloop located at Buffalo in Erie County, New York. It was designed by John G. Alden and built by Goudy & Stevens Shipyard in Boothbay, Maine. It was designed in 1950 and launched in 1952. She measures 34 feet, 4 inches (10.46 m) in length, 7 feet (2.10 m) in beam, and with her fixed keel has a draft of 4 feet, 11 inches (1.50 m). She was moved to Buffalo in the mid-1980s after sailing on Lake Champlain.It was listed on the National Register of Historic Places in 2013.

USS The Sullivans (DD-537) is a retired United States Navy Fletcher-class destroyer. The ship was named in honor of the five Sullivan brothers (George, Francis, Joseph, Madison, and Albert) aged 20 to 27 who lost their lives when their ship, USS Juneau, was sunk by a Japanese submarine during the Naval Battle of Guadalcanal on 13 November 1942. This was the greatest military loss by any one American family during World War II. She was also the first ship commissioned in the Navy that honored more than one person. After service in both World War II and the Korean War, The Sullivans was assigned to the 6th Fleet and was a training ship until she was decommissioned on 7 January 1965. In 1977, she and cruiser USS Little Rock were processed for donation to the Buffalo and Erie County Naval & Military Park in Buffalo, New York. The ship now serves as a memorial museum ship and is open for public tours. On 13 April 2022, the USS The Sullivans partially sank from a severe hull breach.