Casa Miguel C. Godreau

The Centro Ponceño de Autismo (English: Ponce Autism Center), or CEPA, is the only center specialized in the diagnosis and treatment of autism in Puerto Rico. It is a non-profit organization. The center leads progressive research studies and medical training while providing comprehensive, personalized care to children and adults with Autism Spectrum Disorders (ASD), including Asperger's Disorder and PDD NOS. Working together with families, the Centro Ponceño de Autismo aims to identify the causes of autism and advance effective treatments. In 2011, it was reported that the Center cared for 179 patients.

The Residencia Subirá (Subirá Residence), also known as Residencia Frau (Frau Residence), is a historic building located on Reina Street in Ponce, Puerto Rico, in the city's historic district. The building dates from 1910. It was designed by the architect Blas Silva. The architecture follows the Ponce Creole tradition.

Casa Wiechers-Villaronga is a Classical Revival style mansion in Ponce, Puerto Rico designed and built in the early twentieth century. The house was acquired and restored by the Institute of Puerto Rican Culture and now operates as the Museo de la Arquitectura Ponceña (Museum of Ponce Architecture). The house sits in the Ponce Historic Zone. The Villaronga Residence is an outstanding example of the Classical Revival style in used in Ponce designs in the early part of the 20th century and is one of two residences still standing of a series of houses designed and built by Alfredo B. Wiechers, so important to the architectural and cultural heritage of the city of Ponce.

The Museo de la Arquitectura Ponceña (Museum of Ponce Architecture) is an architecture museum housed at the Casa Wiechers-Villaronga, in Ponce, Puerto Rico. It is preserves the history of the architectural styles of Ponce and Puerto Rico. The Casa Wiechers-Villaronga was acquired and restored by the Institute of Puerto Rican Culture. The museum is located in the Ponce Historic Zone. The historic house was designed and built in 1912 by Alfredo B. Wiechers. The house that is home to this architecture museum is itself an example of the architectural history of the city. The museum is housed at the historic Casa Wiechers-Villaronga.

The Primera Iglesia Metodista Unida de Ponce (English: First United Methodist Church of Ponce. Officially, Missionary Society of the Methodist Episcopal Church) was the first structure erected in Puerto Rico by the celebrated architect Antonin Nechodoma. Constructed in 1907, the building houses a Methodist congregation and is located on Villa street in Ponce, Puerto Rico, in the city's historic district. The structure was listed on the U.S. National Register of Historic Places on 29 October 1987.

Parque Graciela Rivera is a small, but charming, passive park in Barrio Primero, Ponce, Puerto Rico, at the intersection of Calla Aurora and Calle Torre/Calle Azucena. It is flanked by the statue of a woman called "La Labradora" (The Reaper). The park was named after the Puerto Rican soprano singer Graciela Rivera.

Segundo (Barrio Segundo) is one of the 31 barrios of the municipality of Ponce, Puerto Rico. Along with Primero, Tercero, Cuarto, Quinto, and Sexto, Segundo is one of the municipality's six core urban barrios. It was organized in 1878. Barrio Segundo has 3 subbarrios: Baldority de Castro (or just "Baldorioty"), Clausells, and Reparada.

Terminal de Transportación Pública Carlos Garay (Carlos Garay Public Transportation Terminal), formerly, Terminal de Carros Públicos Carlos Garay (Carlos Garay Carros Públicos Terminal), is a public transportation terminal for shared ride passengers and SITRAS bus system in Ponce, Puerto Rico. It is located on the block bounded by Calle Vives, Calle Unión, Calle Victoria and Calle Mendez Vigo, in the Ponce Historic Zone, two blocks northwest of the main city square, Plaza Las Delicias. It opened in 1987. On a typical weekday, approximately 500 passengers on about 40 buses and shared-ride vehicles use the station. The building is an example of 1960s urban renewal. When at its peak, the Carlos Garay terminal accommodates over 100 públicos.

The Rosaly–Batiz House (Spanish: Residencia Rosaly-Batiz) is a historic building located on Villa street in Barrio Primero in Ponce, Puerto Rico, in the city's historic district. The building dates from 1897. It was designed by Manuel V. Domenech, a Puerto Rican architect that was responsible for designing various other now-historic buildings. Domenech built this residence for Ponce mayor Pedro Juan Rosaly. Domenech himself became mayor of Ponce and held numerous other political positions in Puerto Rico. The Batiz Residence is a monument to a great man and his works and a vivid reminder of the aristocracy of the years prior to the Great Depression.

The Panteón Nacional Román Baldorioty de Castro (English: Román Baldorioty de Castro National Pantheon) is a tract of land in Barrio Segundo of the city of Ponce, Puerto Rico, originally designed as the city's cemetery, but later converted into what has come to be a famous burial place. Established in 1842, it is Puerto Rico's first (and only) national pantheon. It is the only cemetery dedicated as a museum in Puerto Rico and the Caribbean. Prior to being dedicated as a Panteón Nacional, it was known as Cementerio Viejo or as Cementerio Antiguo de Ponce, and is listed under that name on the U.S. National Register of Historic Places. The Pantheon is named after Román Baldorioty de Castro, a prolific Puerto Rican politician, and firm believer of Puerto Rican autonomy and independence. His remains are located here. The Pantheon also houses a small museum about the history of autonomism in the Island, and it is currently used both as a park and a venue for the expression of culture and the arts. It is called the Museo del Autonomismo Puertorriqueño. Prior to being turned into a National Pantheon in 1991, it was known as Antiguo Cementerio de Ponce (Ponce's Old Cemetery), to differentiate it from the newer (though now also over 100 years old) Cementerio Civil de Ponce (Ponce Civil Cemetery). Built in 1842, after the design of Antonio Torruella, the cemetery was enlarged in 1864, following the design of Nieto Blajol Iglesia. It closed in 1918.

The Ponce Plaza Hotel & Casino, formerly Ponce Ramada Hotel and Ponce Plaza Ramada Hotel, is a five-story hotel in Ponce, Puerto Rico. The hotel opened in the summer of 2009 and is known for the historic value of its structure: its main entrance is a historic colonial structure known as "Casa Saurí" (Saurí House). In February 2013, the hotel expanded its facilities to include a casino, a cocktail lounge, and a 4-story, 200-car parking garage. On 1 July 2014, the owners left the Ramada namesake franchise and renamed the hotel Ponce Plaza Hotel & Casino.

Residencia Armstrong-Poventud (Armstrong-Poventud Residence) is a historic building located in the Ponce Historic Zone in Ponce, Puerto Rico, across from the Catedral Nuestra Señora de Guadalupe. The construction of this home set the stage for the construction of other homes of similar architectural elements, character and opulence in turn-of-the-twentieth-century Ponce.: 3  The architectural style is collectively known as Ponce Creole. The home was designed and built by Manuel Víctor Domenech for the Armstrong-Poventud family. It is listed on the U.S. National Register of Historic Places as the Armstrong-Toro House, and is also known as the Casa de las Cariatides. In 1991, the Instituto de Cultura Puertorriqueña turned the house into a museum, which it manages.